The use of nanocrystalline cellulose for the binding and controlled release of drugs

John K Jackson1, Kevin Letchford1, Benjamin Z Wasserman1, Lucy Ye1, Wadood Y Hamad2, Helen M Burt11Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada; 2FPInnovations, 3800 Wesbrook Mall, Vancouver, BC, CanadaAbstract: The objective of this work...

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Autores principales:	John K Jackson, Kevin Letchford, Benjamin Z Wasserman, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c5f5a16b7628433ca7d6f3f34dcac1c6
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spelling	oai:doaj.org-article:c5f5a16b7628433ca7d6f3f34dcac1c62021-12-02T11:07:30ZThe use of nanocrystalline cellulose for the binding and controlled release of drugs1176-91141178-2013https://doaj.org/article/c5f5a16b7628433ca7d6f3f34dcac1c62011-02-01T00:00:00Zhttp://www.dovepress.com/the-use-of-nanocrystalline-cellulose-for-the-binding-and-controlled-re-a6279https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013John K Jackson1, Kevin Letchford1, Benjamin Z Wasserman1, Lucy Ye1, Wadood Y Hamad2, Helen M Burt11Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada; 2FPInnovations, 3800 Wesbrook Mall, Vancouver, BC, CanadaAbstract: The objective of this work was to investigate the use of nanocrystalline cellulose (NCC) as a drug delivery excipient. NCC crystallites, prepared by an acid hydrolysis method, were shown to have nanoscopic dimensions and exhibit a high degree of crystallinity. These crystallites bound significant quantities of the water soluble, ionizable drugs tetratcycline and doxorubicin, which were released rapidly over a 1-day period. Cetyl trimethylammonium bromide (CTAB) was bound to the surface of NCC and increased the zeta potential in a concentration-dependent manner from -55 to 0 mV. NCC crystallites with CTAB-modified surfaces bound significant quantities of the hydrophobic anticancer drugs docetaxel, paclitaxel, and etoposide. These drugs were released in a controlled manner over a 2-day period. The NCC-CTAB complexes were found to bind to KU-7 cells, and evidence of cellular uptake was observed.Keywords: drug delivery, nanocrystalline cellulose, controlled release John K JacksonKevin LetchfordBenjamin Z Wassermanet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 321-330 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 John K Jackson Kevin Letchford Benjamin Z Wasserman et al The use of nanocrystalline cellulose for the binding and controlled release of drugs
description	John K Jackson1, Kevin Letchford1, Benjamin Z Wasserman1, Lucy Ye1, Wadood Y Hamad2, Helen M Burt11Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada; 2FPInnovations, 3800 Wesbrook Mall, Vancouver, BC, CanadaAbstract: The objective of this work was to investigate the use of nanocrystalline cellulose (NCC) as a drug delivery excipient. NCC crystallites, prepared by an acid hydrolysis method, were shown to have nanoscopic dimensions and exhibit a high degree of crystallinity. These crystallites bound significant quantities of the water soluble, ionizable drugs tetratcycline and doxorubicin, which were released rapidly over a 1-day period. Cetyl trimethylammonium bromide (CTAB) was bound to the surface of NCC and increased the zeta potential in a concentration-dependent manner from -55 to 0 mV. NCC crystallites with CTAB-modified surfaces bound significant quantities of the hydrophobic anticancer drugs docetaxel, paclitaxel, and etoposide. These drugs were released in a controlled manner over a 2-day period. The NCC-CTAB complexes were found to bind to KU-7 cells, and evidence of cellular uptake was observed.Keywords: drug delivery, nanocrystalline cellulose, controlled release
format	article
author	John K Jackson Kevin Letchford Benjamin Z Wasserman et al
author_facet	John K Jackson Kevin Letchford Benjamin Z Wasserman et al
author_sort	John K Jackson
title	The use of nanocrystalline cellulose for the binding and controlled release of drugs
title_short	The use of nanocrystalline cellulose for the binding and controlled release of drugs
title_full	The use of nanocrystalline cellulose for the binding and controlled release of drugs
title_fullStr	The use of nanocrystalline cellulose for the binding and controlled release of drugs
title_full_unstemmed	The use of nanocrystalline cellulose for the binding and controlled release of drugs
title_sort	use of nanocrystalline cellulose for the binding and controlled release of drugs
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/c5f5a16b7628433ca7d6f3f34dcac1c6
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The use of nanocrystalline cellulose for the binding and controlled release of drugs

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