Evolution of mitochondria reconstructed from the energy metabolism of living bacteria.

The ancestors of mitochondria, or proto-mitochondria, played a crucial role in the evolution of eukaryotic cells and derived from symbiotic α-proteobacteria which merged with other microorganisms - the basis of the widely accepted endosymbiotic theory. However, the identity and relatives of proto-mi...

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Autores principales:	Mauro Degli Esposti, Bessem Chouaia, Francesco Comandatore, Elena Crotti, Davide Sassera, Patricia Marie-Jeanne Lievens, Daniele Daffonchio, Claudio Bandi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c5f7b3e52fda4d5ea347b50dd358031f
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spelling	oai:doaj.org-article:c5f7b3e52fda4d5ea347b50dd358031f2021-11-18T08:20:27ZEvolution of mitochondria reconstructed from the energy metabolism of living bacteria.1932-620310.1371/journal.pone.0096566https://doaj.org/article/c5f7b3e52fda4d5ea347b50dd358031f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24804722/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The ancestors of mitochondria, or proto-mitochondria, played a crucial role in the evolution of eukaryotic cells and derived from symbiotic α-proteobacteria which merged with other microorganisms - the basis of the widely accepted endosymbiotic theory. However, the identity and relatives of proto-mitochondria remain elusive. Here we show that methylotrophic α-proteobacteria could be the closest living models for mitochondrial ancestors. We reached this conclusion after reconstructing the possible evolutionary pathways of the bioenergy systems of proto-mitochondria with a genomic survey of extant α-proteobacteria. Results obtained with complementary molecular and genetic analyses of diverse bioenergetic proteins converge in indicating the pathway stemming from methylotrophic bacteria as the most probable route of mitochondrial evolution. Contrary to other α-proteobacteria, methylotrophs show transition forms for the bioenergetic systems analysed. Our approach of focusing on these bioenergetic systems overcomes the phylogenetic impasse that has previously complicated the search for mitochondrial ancestors. Moreover, our results provide a new perspective for experimentally re-evolving mitochondria from extant bacteria and in the future produce synthetic mitochondria.Mauro Degli EspostiBessem ChouaiaFrancesco ComandatoreElena CrottiDavide SasseraPatricia Marie-Jeanne LievensDaniele DaffonchioClaudio BandiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e96566 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mauro Degli Esposti Bessem Chouaia Francesco Comandatore Elena Crotti Davide Sassera Patricia Marie-Jeanne Lievens Daniele Daffonchio Claudio Bandi Evolution of mitochondria reconstructed from the energy metabolism of living bacteria.
description	The ancestors of mitochondria, or proto-mitochondria, played a crucial role in the evolution of eukaryotic cells and derived from symbiotic α-proteobacteria which merged with other microorganisms - the basis of the widely accepted endosymbiotic theory. However, the identity and relatives of proto-mitochondria remain elusive. Here we show that methylotrophic α-proteobacteria could be the closest living models for mitochondrial ancestors. We reached this conclusion after reconstructing the possible evolutionary pathways of the bioenergy systems of proto-mitochondria with a genomic survey of extant α-proteobacteria. Results obtained with complementary molecular and genetic analyses of diverse bioenergetic proteins converge in indicating the pathway stemming from methylotrophic bacteria as the most probable route of mitochondrial evolution. Contrary to other α-proteobacteria, methylotrophs show transition forms for the bioenergetic systems analysed. Our approach of focusing on these bioenergetic systems overcomes the phylogenetic impasse that has previously complicated the search for mitochondrial ancestors. Moreover, our results provide a new perspective for experimentally re-evolving mitochondria from extant bacteria and in the future produce synthetic mitochondria.
format	article
author	Mauro Degli Esposti Bessem Chouaia Francesco Comandatore Elena Crotti Davide Sassera Patricia Marie-Jeanne Lievens Daniele Daffonchio Claudio Bandi
author_facet	Mauro Degli Esposti Bessem Chouaia Francesco Comandatore Elena Crotti Davide Sassera Patricia Marie-Jeanne Lievens Daniele Daffonchio Claudio Bandi
author_sort	Mauro Degli Esposti
title	Evolution of mitochondria reconstructed from the energy metabolism of living bacteria.
title_short	Evolution of mitochondria reconstructed from the energy metabolism of living bacteria.
title_full	Evolution of mitochondria reconstructed from the energy metabolism of living bacteria.
title_fullStr	Evolution of mitochondria reconstructed from the energy metabolism of living bacteria.
title_full_unstemmed	Evolution of mitochondria reconstructed from the energy metabolism of living bacteria.
title_sort	evolution of mitochondria reconstructed from the energy metabolism of living bacteria.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/c5f7b3e52fda4d5ea347b50dd358031f
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Evolution of mitochondria reconstructed from the energy metabolism of living bacteria.

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