Enzymes are enriched in bacterial essential genes.

Essential genes, those indispensable for the survival of an organism, play a key role in the emerging field, synthetic biology. Characterization of functions encoded by essential genes not only has important practical implications, such as in identifying antibiotic drug targets, but can also enhance...

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Autores principales:	Feng Gao, Randy Ren Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c5f984397b924df78f5b65def87c2c0a
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spelling	oai:doaj.org-article:c5f984397b924df78f5b65def87c2c0a2021-11-18T06:51:04ZEnzymes are enriched in bacterial essential genes.1932-620310.1371/journal.pone.0021683https://doaj.org/article/c5f984397b924df78f5b65def87c2c0a2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21738765/?tool=EBIhttps://doaj.org/toc/1932-6203Essential genes, those indispensable for the survival of an organism, play a key role in the emerging field, synthetic biology. Characterization of functions encoded by essential genes not only has important practical implications, such as in identifying antibiotic drug targets, but can also enhance our understanding of basic biology, such as functions needed to support cellular life. Enzymes are critical for almost all cellular activities. However, essential genes have not been systematically examined from the aspect of enzymes and the chemical reactions that they catalyze. Here, by comprehensively analyzing essential genes in 14 bacterial genomes in which large-scale gene essentiality screens have been performed, we found that enzymes are enriched in essential genes. Essential enzymes have overrepresented ligases (especially those forming carbon-oxygen bonds and carbon-nitrogen bonds), nucleotidyltransferases and phosphotransferases, while have underrepresented oxidoreductases. Furthermore, essential enzymes tend to associate with more gene ontology domains. These results, from the aspect of chemical reactions, provide further insights into the understanding of functions needed to support natural cellular life, as well as synthetic cells, and provide additional parameters that can be integrated into gene essentiality prediction algorithms.Feng GaoRandy Ren ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e21683 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Feng Gao Randy Ren Zhang Enzymes are enriched in bacterial essential genes.
description	Essential genes, those indispensable for the survival of an organism, play a key role in the emerging field, synthetic biology. Characterization of functions encoded by essential genes not only has important practical implications, such as in identifying antibiotic drug targets, but can also enhance our understanding of basic biology, such as functions needed to support cellular life. Enzymes are critical for almost all cellular activities. However, essential genes have not been systematically examined from the aspect of enzymes and the chemical reactions that they catalyze. Here, by comprehensively analyzing essential genes in 14 bacterial genomes in which large-scale gene essentiality screens have been performed, we found that enzymes are enriched in essential genes. Essential enzymes have overrepresented ligases (especially those forming carbon-oxygen bonds and carbon-nitrogen bonds), nucleotidyltransferases and phosphotransferases, while have underrepresented oxidoreductases. Furthermore, essential enzymes tend to associate with more gene ontology domains. These results, from the aspect of chemical reactions, provide further insights into the understanding of functions needed to support natural cellular life, as well as synthetic cells, and provide additional parameters that can be integrated into gene essentiality prediction algorithms.
format	article
author	Feng Gao Randy Ren Zhang
author_facet	Feng Gao Randy Ren Zhang
author_sort	Feng Gao
title	Enzymes are enriched in bacterial essential genes.
title_short	Enzymes are enriched in bacterial essential genes.
title_full	Enzymes are enriched in bacterial essential genes.
title_fullStr	Enzymes are enriched in bacterial essential genes.
title_full_unstemmed	Enzymes are enriched in bacterial essential genes.
title_sort	enzymes are enriched in bacterial essential genes.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/c5f984397b924df78f5b65def87c2c0a
work_keys_str_mv	AT fenggao enzymesareenrichedinbacterialessentialgenes AT randyrenzhang enzymesareenrichedinbacterialessentialgenes
_version_	1718424318305632256

Enzymes are enriched in bacterial essential genes.

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