Dynamic changes of acquired maternal SARS-CoV-2 IgG in infants

Abstract At present, there are still ambiguous reports about the perinatal infection of infants born to mothers infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The dynamic characteristics of infantile serum antibodies born to mother with SARS-CoV-2 has not been well descr...

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Autores principales:	Xia Wang, Pu Yang, Junwen Zheng, Pin Liu, Cong Wei, Juanjuan Guo, Yuanzhen Zhang, Dongchi Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c5ff319363754a50a00e50e2385a4b00
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spelling	oai:doaj.org-article:c5ff319363754a50a00e50e2385a4b002021-12-02T14:26:25ZDynamic changes of acquired maternal SARS-CoV-2 IgG in infants10.1038/s41598-021-87535-x2045-2322https://doaj.org/article/c5ff319363754a50a00e50e2385a4b002021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87535-xhttps://doaj.org/toc/2045-2322Abstract At present, there are still ambiguous reports about the perinatal infection of infants born to mothers infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The dynamic characteristics of infantile serum antibodies born to mother with SARS-CoV-2 has not been well described. In this study, we analyzed the seroconversion of 27 newborns born to 26 pregnant women infected with SARS-CoV-2. The SARS-CoV-2 IgG positive rate of parturient was 80.8%, and half of their infants obtained maternal IgG. IgG transfer rates were 18.8% and 81.8% in those infants whose mother infected less and more than 2 weeks before delivery. In the first two months of life, the IgG level of infants dropped sharply to one tenth of that at birth. These results suggest that maternal SARS-CoV-2 IgG provides limited protection for infants.Xia WangPu YangJunwen ZhengPin LiuCong WeiJuanjuan GuoYuanzhen ZhangDongchi ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xia Wang Pu Yang Junwen Zheng Pin Liu Cong Wei Juanjuan Guo Yuanzhen Zhang Dongchi Zhao Dynamic changes of acquired maternal SARS-CoV-2 IgG in infants
description	Abstract At present, there are still ambiguous reports about the perinatal infection of infants born to mothers infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The dynamic characteristics of infantile serum antibodies born to mother with SARS-CoV-2 has not been well described. In this study, we analyzed the seroconversion of 27 newborns born to 26 pregnant women infected with SARS-CoV-2. The SARS-CoV-2 IgG positive rate of parturient was 80.8%, and half of their infants obtained maternal IgG. IgG transfer rates were 18.8% and 81.8% in those infants whose mother infected less and more than 2 weeks before delivery. In the first two months of life, the IgG level of infants dropped sharply to one tenth of that at birth. These results suggest that maternal SARS-CoV-2 IgG provides limited protection for infants.
format	article
author	Xia Wang Pu Yang Junwen Zheng Pin Liu Cong Wei Juanjuan Guo Yuanzhen Zhang Dongchi Zhao
author_facet	Xia Wang Pu Yang Junwen Zheng Pin Liu Cong Wei Juanjuan Guo Yuanzhen Zhang Dongchi Zhao
author_sort	Xia Wang
title	Dynamic changes of acquired maternal SARS-CoV-2 IgG in infants
title_short	Dynamic changes of acquired maternal SARS-CoV-2 IgG in infants
title_full	Dynamic changes of acquired maternal SARS-CoV-2 IgG in infants
title_fullStr	Dynamic changes of acquired maternal SARS-CoV-2 IgG in infants
title_full_unstemmed	Dynamic changes of acquired maternal SARS-CoV-2 IgG in infants
title_sort	dynamic changes of acquired maternal sars-cov-2 igg in infants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c5ff319363754a50a00e50e2385a4b00
work_keys_str_mv	AT xiawang dynamicchangesofacquiredmaternalsarscov2iggininfants AT puyang dynamicchangesofacquiredmaternalsarscov2iggininfants AT junwenzheng dynamicchangesofacquiredmaternalsarscov2iggininfants AT pinliu dynamicchangesofacquiredmaternalsarscov2iggininfants AT congwei dynamicchangesofacquiredmaternalsarscov2iggininfants AT juanjuanguo dynamicchangesofacquiredmaternalsarscov2iggininfants AT yuanzhenzhang dynamicchangesofacquiredmaternalsarscov2iggininfants AT dongchizhao dynamicchangesofacquiredmaternalsarscov2iggininfants
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Dynamic changes of acquired maternal SARS-CoV-2 IgG in infants

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