Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.

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Autores principales:	Tuomas O. Kilpeläinen, Amy R. Bentley, Raymond Noordam, Yun Ju Sung, Karen Schwander, Thomas W. Winkler, Hermina Jakupović, Daniel I. Chasman, Alisa Manning, Ioanna Ntalla, Hugues Aschard, Michael R. Brown, Lisa de las Fuentes, Nora Franceschini, Xiuqing Guo, Dina Vojinovic, Stella Aslibekyan, Mary F. Feitosa, Minjung Kho, Solomon K. Musani, Melissa Richard, Heming Wang, Zhe Wang, Traci M. Bartz, Lawrence F. Bielak, Archie Campbell, Rajkumar Dorajoo, Virginia Fisher, Fernando P. Hartwig, Andrea R. V. R. Horimoto, Changwei Li, Kurt K. Lohman, Jonathan Marten, Xueling Sim, Albert V. Smith, Salman M. Tajuddin, Maris Alver, Marzyeh Amini, Mathilde Boissel, Jin Fang Chai, Xu Chen, Jasmin Divers, Evangelos Evangelou, Chuan Gao, Mariaelisa Graff, Sarah E. Harris, Meian He, Fang-Chi Hsu, Anne U. Jackson, Jing Hua Zhao, Aldi T. Kraja, Brigitte Kühnel, Federica Laguzzi, Leo-Pekka Lyytikäinen, Ilja M. Nolte, Rainer Rauramaa, Muhammad Riaz, Antonietta Robino, Rico Rueedi, Heather M. Stringham, Fumihiko Takeuchi, Peter J. van der Most, Tibor V. Varga, Niek Verweij, Erin B. Ware, Wanqing Wen, Xiaoyin Li, Lisa R. Yanek, Najaf Amin, Donna K. Arnett, Eric Boerwinkle, Marco Brumat, Brian Cade, Mickaël Canouil, Yii-Der Ida Chen, Maria Pina Concas, John Connell, Renée de Mutsert, H. Janaka de Silva, Paul S. de Vries, Ayşe Demirkan, Jingzhong Ding, Charles B. Eaton, Jessica D. Faul, Yechiel Friedlander, Kelley P. Gabriel, Mohsen Ghanbari, Franco Giulianini, Chi Charles Gu, Dongfeng Gu, Tamara B. Harris, Jiang He, Sami Heikkinen, Chew-Kiat Heng, Steven C. Hunt, M. Arfan Ikram, Jost B. Jonas, Woon-Puay Koh, Pirjo Komulainen, Jose E. Krieger, Stephen B. Kritchevsky, Zoltán Kutalik, Johanna Kuusisto, Carl D. Langefeld, Claudia Langenberg, Lenore J. Launer, Karin Leander, Rozenn N. Lemaitre, Cora E. Lewis, Jingjing Liang, Lifelines Cohort Study, Jianjun Liu, Reedik Mägi, Ani Manichaikul, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Karen L. Mohlke, Thomas H. Mosley, Alison D. Murray, Mike A. Nalls, Ei-Ei Khaing Nang, Christopher P. Nelson, Sotoodehnia Nona, Jill M. Norris, Chiamaka Vivian Nwuba, Jeff O’Connell, Nicholette D. Palmer, George J. Papanicolau, Raha Pazoki, Nancy L. Pedersen, Annette Peters, Patricia A. Peyser, Ozren Polasek, David J. Porteous, Alaitz Poveda, Olli T. Raitakari, Stephen S. Rich, Neil Risch, Jennifer G. Robinson, Lynda M. Rose, Igor Rudan, Pamela J. Schreiner, Robert A. Scott, Stephen S. Sidney, Mario Sims, Jennifer A. Smith, Harold Snieder, Tamar Sofer, John M. Starr, Barbara Sternfeld, Konstantin Strauch, Hua Tang, Kent D. Taylor, Michael Y. Tsai, Jaakko Tuomilehto, André G. Uitterlinden, M. Yldau van der Ende, Diana van Heemst, Trudy Voortman, Melanie Waldenberger, Patrik Wennberg, Gregory Wilson, Yong-Bing Xiang, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Alan B. Zonderman, Diane M. Becker, Michael Boehnke, Donald W. Bowden, Ulf de Faire, Ian J. Deary, Paul Elliott, Tõnu Esko, Barry I. Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Norihiro Kato, Markku Laakso, Timo A. Lakka, Terho Lehtimäki, Patrik K. E. Magnusson, Albertine J. Oldehinkel, Brenda W. J. H. Penninx, Nilesh J. Samani, Xiao-Ou Shu, Pim van der Harst, Jana V. Van Vliet-Ostaptchouk, Peter Vollenweider, Lynne E. Wagenknecht, Ya X. Wang, Nicholas J. Wareham, David R. Weir, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Michele K. Evans, Paul W. Franks, Vilmundur Gudnason, Caroline Hayward, Bernardo L. Horta, Tanika N. Kelly, Yongmei Liu, Kari E. North, Alexandre C. Pereira, Paul M. Ridker, E. Shyong Tai, Rob M. van Dam, Ervin R. Fox, Sharon L. R. Kardia, Ching-Ti Liu, Dennis O. Mook-Kanamori, Michael A. Province, Susan Redline, Cornelia M. van Duijn, Jerome I. Rotter, Charles B. Kooperberg, W. James Gauderman, Bruce M. Psaty, Kenneth Rice, Patricia B. Munroe, Myriam Fornage, L. Adrienne Cupples, Charles N. Rotimi, Alanna C. Morrison, Dabeeru C. Rao, Ruth J. F. Loos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c601bbeb13aa47908700d9f090698e14
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id	oai:doaj.org-article:c601bbeb13aa47908700d9f090698e14
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institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tuomas O. Kilpeläinen Amy R. Bentley Raymond Noordam Yun Ju Sung Karen Schwander Thomas W. Winkler Hermina Jakupović Daniel I. Chasman Alisa Manning Ioanna Ntalla Hugues Aschard Michael R. Brown Lisa de las Fuentes Nora Franceschini Xiuqing Guo Dina Vojinovic Stella Aslibekyan Mary F. Feitosa Minjung Kho Solomon K. Musani Melissa Richard Heming Wang Zhe Wang Traci M. Bartz Lawrence F. Bielak Archie Campbell Rajkumar Dorajoo Virginia Fisher Fernando P. Hartwig Andrea R. V. R. Horimoto Changwei Li Kurt K. Lohman Jonathan Marten Xueling Sim Albert V. Smith Salman M. Tajuddin Maris Alver Marzyeh Amini Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Evangelos Evangelou Chuan Gao Mariaelisa Graff Sarah E. Harris Meian He Fang-Chi Hsu Anne U. Jackson Jing Hua Zhao Aldi T. Kraja Brigitte Kühnel Federica Laguzzi Leo-Pekka Lyytikäinen Ilja M. Nolte Rainer Rauramaa Muhammad Riaz Antonietta Robino Rico Rueedi Heather M. Stringham Fumihiko Takeuchi Peter J. van der Most Tibor V. Varga Niek Verweij Erin B. Ware Wanqing Wen Xiaoyin Li Lisa R. Yanek Najaf Amin Donna K. Arnett Eric Boerwinkle Marco Brumat Brian Cade Mickaël Canouil Yii-Der Ida Chen Maria Pina Concas John Connell Renée de Mutsert H. Janaka de Silva Paul S. de Vries Ayşe Demirkan Jingzhong Ding Charles B. Eaton Jessica D. Faul Yechiel Friedlander Kelley P. Gabriel Mohsen Ghanbari Franco Giulianini Chi Charles Gu Dongfeng Gu Tamara B. Harris Jiang He Sami Heikkinen Chew-Kiat Heng Steven C. Hunt M. Arfan Ikram Jost B. Jonas Woon-Puay Koh Pirjo Komulainen Jose E. Krieger Stephen B. Kritchevsky Zoltán Kutalik Johanna Kuusisto Carl D. Langefeld Claudia Langenberg Lenore J. Launer Karin Leander Rozenn N. Lemaitre Cora E. Lewis Jingjing Liang Lifelines Cohort Study Jianjun Liu Reedik Mägi Ani Manichaikul Thomas Meitinger Andres Metspalu Yuri Milaneschi Karen L. Mohlke Thomas H. Mosley Alison D. Murray Mike A. Nalls Ei-Ei Khaing Nang Christopher P. Nelson Sotoodehnia Nona Jill M. Norris Chiamaka Vivian Nwuba Jeff O’Connell Nicholette D. Palmer George J. Papanicolau Raha Pazoki Nancy L. Pedersen Annette Peters Patricia A. Peyser Ozren Polasek David J. Porteous Alaitz Poveda Olli T. Raitakari Stephen S. Rich Neil Risch Jennifer G. Robinson Lynda M. Rose Igor Rudan Pamela J. Schreiner Robert A. Scott Stephen S. Sidney Mario Sims Jennifer A. Smith Harold Snieder Tamar Sofer John M. Starr Barbara Sternfeld Konstantin Strauch Hua Tang Kent D. Taylor Michael Y. Tsai Jaakko Tuomilehto André G. Uitterlinden M. Yldau van der Ende Diana van Heemst Trudy Voortman Melanie Waldenberger Patrik Wennberg Gregory Wilson Yong-Bing Xiang Jie Yao Caizheng Yu Jian-Min Yuan Wei Zhao Alan B. Zonderman Diane M. Becker Michael Boehnke Donald W. Bowden Ulf de Faire Ian J. Deary Paul Elliott Tõnu Esko Barry I. Freedman Philippe Froguel Paolo Gasparini Christian Gieger Norihiro Kato Markku Laakso Timo A. Lakka Terho Lehtimäki Patrik K. E. Magnusson Albertine J. Oldehinkel Brenda W. J. H. Penninx Nilesh J. Samani Xiao-Ou Shu Pim van der Harst Jana V. Van Vliet-Ostaptchouk Peter Vollenweider Lynne E. Wagenknecht Ya X. Wang Nicholas J. Wareham David R. Weir Tangchun Wu Wei Zheng Xiaofeng Zhu Michele K. Evans Paul W. Franks Vilmundur Gudnason Caroline Hayward Bernardo L. Horta Tanika N. Kelly Yongmei Liu Kari E. North Alexandre C. Pereira Paul M. Ridker E. Shyong Tai Rob M. van Dam Ervin R. Fox Sharon L. R. Kardia Ching-Ti Liu Dennis O. Mook-Kanamori Michael A. Province Susan Redline Cornelia M. van Duijn Jerome I. Rotter Charles B. Kooperberg W. James Gauderman Bruce M. Psaty Kenneth Rice Patricia B. Munroe Myriam Fornage L. Adrienne Cupples Charles N. Rotimi Alanna C. Morrison Dabeeru C. Rao Ruth J. F. Loos Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
description	GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.
format	article
author	Tuomas O. Kilpeläinen Amy R. Bentley Raymond Noordam Yun Ju Sung Karen Schwander Thomas W. Winkler Hermina Jakupović Daniel I. Chasman Alisa Manning Ioanna Ntalla Hugues Aschard Michael R. Brown Lisa de las Fuentes Nora Franceschini Xiuqing Guo Dina Vojinovic Stella Aslibekyan Mary F. Feitosa Minjung Kho Solomon K. Musani Melissa Richard Heming Wang Zhe Wang Traci M. Bartz Lawrence F. Bielak Archie Campbell Rajkumar Dorajoo Virginia Fisher Fernando P. Hartwig Andrea R. V. R. Horimoto Changwei Li Kurt K. Lohman Jonathan Marten Xueling Sim Albert V. Smith Salman M. Tajuddin Maris Alver Marzyeh Amini Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Evangelos Evangelou Chuan Gao Mariaelisa Graff Sarah E. Harris Meian He Fang-Chi Hsu Anne U. Jackson Jing Hua Zhao Aldi T. Kraja Brigitte Kühnel Federica Laguzzi Leo-Pekka Lyytikäinen Ilja M. Nolte Rainer Rauramaa Muhammad Riaz Antonietta Robino Rico Rueedi Heather M. Stringham Fumihiko Takeuchi Peter J. van der Most Tibor V. Varga Niek Verweij Erin B. Ware Wanqing Wen Xiaoyin Li Lisa R. Yanek Najaf Amin Donna K. Arnett Eric Boerwinkle Marco Brumat Brian Cade Mickaël Canouil Yii-Der Ida Chen Maria Pina Concas John Connell Renée de Mutsert H. Janaka de Silva Paul S. de Vries Ayşe Demirkan Jingzhong Ding Charles B. Eaton Jessica D. Faul Yechiel Friedlander Kelley P. Gabriel Mohsen Ghanbari Franco Giulianini Chi Charles Gu Dongfeng Gu Tamara B. Harris Jiang He Sami Heikkinen Chew-Kiat Heng Steven C. Hunt M. Arfan Ikram Jost B. Jonas Woon-Puay Koh Pirjo Komulainen Jose E. Krieger Stephen B. Kritchevsky Zoltán Kutalik Johanna Kuusisto Carl D. Langefeld Claudia Langenberg Lenore J. Launer Karin Leander Rozenn N. Lemaitre Cora E. Lewis Jingjing Liang Lifelines Cohort Study Jianjun Liu Reedik Mägi Ani Manichaikul Thomas Meitinger Andres Metspalu Yuri Milaneschi Karen L. Mohlke Thomas H. Mosley Alison D. Murray Mike A. Nalls Ei-Ei Khaing Nang Christopher P. Nelson Sotoodehnia Nona Jill M. Norris Chiamaka Vivian Nwuba Jeff O’Connell Nicholette D. Palmer George J. Papanicolau Raha Pazoki Nancy L. Pedersen Annette Peters Patricia A. Peyser Ozren Polasek David J. Porteous Alaitz Poveda Olli T. Raitakari Stephen S. Rich Neil Risch Jennifer G. Robinson Lynda M. Rose Igor Rudan Pamela J. Schreiner Robert A. Scott Stephen S. Sidney Mario Sims Jennifer A. Smith Harold Snieder Tamar Sofer John M. Starr Barbara Sternfeld Konstantin Strauch Hua Tang Kent D. Taylor Michael Y. Tsai Jaakko Tuomilehto André G. Uitterlinden M. Yldau van der Ende Diana van Heemst Trudy Voortman Melanie Waldenberger Patrik Wennberg Gregory Wilson Yong-Bing Xiang Jie Yao Caizheng Yu Jian-Min Yuan Wei Zhao Alan B. Zonderman Diane M. Becker Michael Boehnke Donald W. Bowden Ulf de Faire Ian J. Deary Paul Elliott Tõnu Esko Barry I. Freedman Philippe Froguel Paolo Gasparini Christian Gieger Norihiro Kato Markku Laakso Timo A. Lakka Terho Lehtimäki Patrik K. E. Magnusson Albertine J. Oldehinkel Brenda W. J. H. Penninx Nilesh J. Samani Xiao-Ou Shu Pim van der Harst Jana V. Van Vliet-Ostaptchouk Peter Vollenweider Lynne E. Wagenknecht Ya X. Wang Nicholas J. Wareham David R. Weir Tangchun Wu Wei Zheng Xiaofeng Zhu Michele K. Evans Paul W. Franks Vilmundur Gudnason Caroline Hayward Bernardo L. Horta Tanika N. Kelly Yongmei Liu Kari E. North Alexandre C. Pereira Paul M. Ridker E. Shyong Tai Rob M. van Dam Ervin R. Fox Sharon L. R. Kardia Ching-Ti Liu Dennis O. Mook-Kanamori Michael A. Province Susan Redline Cornelia M. van Duijn Jerome I. Rotter Charles B. Kooperberg W. James Gauderman Bruce M. Psaty Kenneth Rice Patricia B. Munroe Myriam Fornage L. Adrienne Cupples Charles N. Rotimi Alanna C. Morrison Dabeeru C. Rao Ruth J. F. Loos
author_facet	Tuomas O. Kilpeläinen Amy R. Bentley Raymond Noordam Yun Ju Sung Karen Schwander Thomas W. Winkler Hermina Jakupović Daniel I. Chasman Alisa Manning Ioanna Ntalla Hugues Aschard Michael R. Brown Lisa de las Fuentes Nora Franceschini Xiuqing Guo Dina Vojinovic Stella Aslibekyan Mary F. Feitosa Minjung Kho Solomon K. Musani Melissa Richard Heming Wang Zhe Wang Traci M. Bartz Lawrence F. Bielak Archie Campbell Rajkumar Dorajoo Virginia Fisher Fernando P. Hartwig Andrea R. V. R. Horimoto Changwei Li Kurt K. Lohman Jonathan Marten Xueling Sim Albert V. Smith Salman M. Tajuddin Maris Alver Marzyeh Amini Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Evangelos Evangelou Chuan Gao Mariaelisa Graff Sarah E. Harris Meian He Fang-Chi Hsu Anne U. Jackson Jing Hua Zhao Aldi T. Kraja Brigitte Kühnel Federica Laguzzi Leo-Pekka Lyytikäinen Ilja M. Nolte Rainer Rauramaa Muhammad Riaz Antonietta Robino Rico Rueedi Heather M. Stringham Fumihiko Takeuchi Peter J. van der Most Tibor V. Varga Niek Verweij Erin B. Ware Wanqing Wen Xiaoyin Li Lisa R. Yanek Najaf Amin Donna K. Arnett Eric Boerwinkle Marco Brumat Brian Cade Mickaël Canouil Yii-Der Ida Chen Maria Pina Concas John Connell Renée de Mutsert H. Janaka de Silva Paul S. de Vries Ayşe Demirkan Jingzhong Ding Charles B. Eaton Jessica D. Faul Yechiel Friedlander Kelley P. Gabriel Mohsen Ghanbari Franco Giulianini Chi Charles Gu Dongfeng Gu Tamara B. Harris Jiang He Sami Heikkinen Chew-Kiat Heng Steven C. Hunt M. Arfan Ikram Jost B. Jonas Woon-Puay Koh Pirjo Komulainen Jose E. Krieger Stephen B. Kritchevsky Zoltán Kutalik Johanna Kuusisto Carl D. Langefeld Claudia Langenberg Lenore J. Launer Karin Leander Rozenn N. Lemaitre Cora E. Lewis Jingjing Liang Lifelines Cohort Study Jianjun Liu Reedik Mägi Ani Manichaikul Thomas Meitinger Andres Metspalu Yuri Milaneschi Karen L. Mohlke Thomas H. Mosley Alison D. Murray Mike A. Nalls Ei-Ei Khaing Nang Christopher P. Nelson Sotoodehnia Nona Jill M. Norris Chiamaka Vivian Nwuba Jeff O’Connell Nicholette D. Palmer George J. Papanicolau Raha Pazoki Nancy L. Pedersen Annette Peters Patricia A. Peyser Ozren Polasek David J. Porteous Alaitz Poveda Olli T. Raitakari Stephen S. Rich Neil Risch Jennifer G. Robinson Lynda M. Rose Igor Rudan Pamela J. Schreiner Robert A. Scott Stephen S. Sidney Mario Sims Jennifer A. Smith Harold Snieder Tamar Sofer John M. Starr Barbara Sternfeld Konstantin Strauch Hua Tang Kent D. Taylor Michael Y. Tsai Jaakko Tuomilehto André G. Uitterlinden M. Yldau van der Ende Diana van Heemst Trudy Voortman Melanie Waldenberger Patrik Wennberg Gregory Wilson Yong-Bing Xiang Jie Yao Caizheng Yu Jian-Min Yuan Wei Zhao Alan B. Zonderman Diane M. Becker Michael Boehnke Donald W. Bowden Ulf de Faire Ian J. Deary Paul Elliott Tõnu Esko Barry I. Freedman Philippe Froguel Paolo Gasparini Christian Gieger Norihiro Kato Markku Laakso Timo A. Lakka Terho Lehtimäki Patrik K. E. Magnusson Albertine J. Oldehinkel Brenda W. J. H. Penninx Nilesh J. Samani Xiao-Ou Shu Pim van der Harst Jana V. Van Vliet-Ostaptchouk Peter Vollenweider Lynne E. Wagenknecht Ya X. Wang Nicholas J. Wareham David R. Weir Tangchun Wu Wei Zheng Xiaofeng Zhu Michele K. Evans Paul W. Franks Vilmundur Gudnason Caroline Hayward Bernardo L. Horta Tanika N. Kelly Yongmei Liu Kari E. North Alexandre C. Pereira Paul M. Ridker E. Shyong Tai Rob M. van Dam Ervin R. Fox Sharon L. R. Kardia Ching-Ti Liu Dennis O. Mook-Kanamori Michael A. Province Susan Redline Cornelia M. van Duijn Jerome I. Rotter Charles B. Kooperberg W. James Gauderman Bruce M. Psaty Kenneth Rice Patricia B. Munroe Myriam Fornage L. Adrienne Cupples Charles N. Rotimi Alanna C. Morrison Dabeeru C. Rao Ruth J. F. Loos
author_sort	Tuomas O. Kilpeläinen
title	Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
title_short	Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
title_full	Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
title_fullStr	Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
title_full_unstemmed	Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
title_sort	multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c601bbeb13aa47908700d9f090698e14
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multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity AT ruthjfloos multiancestrystudyofbloodlipidlevelsidentifiesfourlociinteractingwithphysicalactivity
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spelling	oai:doaj.org-article:c601bbeb13aa47908700d9f090698e142021-12-02T16:50:56ZMulti-ancestry study of blood lipid levels identifies four loci interacting with physical activity10.1038/s41467-018-08008-w2041-1723https://doaj.org/article/c601bbeb13aa47908700d9f090698e142019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08008-whttps://doaj.org/toc/2041-1723GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.Tuomas O. KilpeläinenAmy R. BentleyRaymond NoordamYun Ju SungKaren SchwanderThomas W. WinklerHermina JakupovićDaniel I. ChasmanAlisa ManningIoanna NtallaHugues AschardMichael R. BrownLisa de las FuentesNora FranceschiniXiuqing GuoDina VojinovicStella AslibekyanMary F. FeitosaMinjung KhoSolomon K. MusaniMelissa RichardHeming WangZhe WangTraci M. BartzLawrence F. BielakArchie CampbellRajkumar DorajooVirginia FisherFernando P. HartwigAndrea R. V. R. HorimotoChangwei LiKurt K. LohmanJonathan MartenXueling SimAlbert V. SmithSalman M. TajuddinMaris AlverMarzyeh AminiMathilde BoisselJin Fang ChaiXu ChenJasmin DiversEvangelos EvangelouChuan GaoMariaelisa GraffSarah E. HarrisMeian HeFang-Chi HsuAnne U. JacksonJing Hua ZhaoAldi T. KrajaBrigitte KühnelFederica LaguzziLeo-Pekka LyytikäinenIlja M. NolteRainer RauramaaMuhammad RiazAntonietta RobinoRico RueediHeather M. StringhamFumihiko TakeuchiPeter J. van der MostTibor V. VargaNiek VerweijErin B. WareWanqing WenXiaoyin LiLisa R. YanekNajaf AminDonna K. ArnettEric BoerwinkleMarco BrumatBrian CadeMickaël CanouilYii-Der Ida ChenMaria Pina ConcasJohn ConnellRenée de MutsertH. Janaka de SilvaPaul S. de VriesAyşe DemirkanJingzhong DingCharles B. EatonJessica D. FaulYechiel FriedlanderKelley P. GabrielMohsen GhanbariFranco GiulianiniChi Charles GuDongfeng GuTamara B. HarrisJiang HeSami HeikkinenChew-Kiat HengSteven C. HuntM. Arfan IkramJost B. JonasWoon-Puay KohPirjo KomulainenJose E. KriegerStephen B. KritchevskyZoltán KutalikJohanna KuusistoCarl D. LangefeldClaudia LangenbergLenore J. LaunerKarin LeanderRozenn N. LemaitreCora E. LewisJingjing LiangLifelines Cohort StudyJianjun LiuReedik MägiAni ManichaikulThomas MeitingerAndres MetspaluYuri MilaneschiKaren L. MohlkeThomas H. MosleyAlison D. MurrayMike A. NallsEi-Ei Khaing NangChristopher P. NelsonSotoodehnia NonaJill M. NorrisChiamaka Vivian NwubaJeff O’ConnellNicholette D. PalmerGeorge J. PapanicolauRaha PazokiNancy L. PedersenAnnette PetersPatricia A. PeyserOzren PolasekDavid J. PorteousAlaitz PovedaOlli T. RaitakariStephen S. RichNeil RischJennifer G. RobinsonLynda M. RoseIgor RudanPamela J. SchreinerRobert A. ScottStephen S. SidneyMario SimsJennifer A. SmithHarold SniederTamar SoferJohn M. StarrBarbara SternfeldKonstantin StrauchHua TangKent D. TaylorMichael Y. TsaiJaakko TuomilehtoAndré G. UitterlindenM. Yldau van der EndeDiana van HeemstTrudy VoortmanMelanie WaldenbergerPatrik WennbergGregory WilsonYong-Bing XiangJie YaoCaizheng YuJian-Min YuanWei ZhaoAlan B. ZondermanDiane M. BeckerMichael BoehnkeDonald W. BowdenUlf de FaireIan J. DearyPaul ElliottTõnu EskoBarry I. FreedmanPhilippe FroguelPaolo GaspariniChristian GiegerNorihiro KatoMarkku LaaksoTimo A. LakkaTerho LehtimäkiPatrik K. E. MagnussonAlbertine J. OldehinkelBrenda W. J. H. PenninxNilesh J. SamaniXiao-Ou ShuPim van der HarstJana V. Van Vliet-OstaptchoukPeter VollenweiderLynne E. WagenknechtYa X. WangNicholas J. WarehamDavid R. WeirTangchun WuWei ZhengXiaofeng ZhuMichele K. EvansPaul W. FranksVilmundur GudnasonCaroline HaywardBernardo L. HortaTanika N. KellyYongmei LiuKari E. NorthAlexandre C. PereiraPaul M. RidkerE. Shyong TaiRob M. van DamErvin R. FoxSharon L. R. KardiaChing-Ti LiuDennis O. Mook-KanamoriMichael A. ProvinceSusan RedlineCornelia M. van DuijnJerome I. RotterCharles B. KooperbergW. James GaudermanBruce M. PsatyKenneth RicePatricia B. MunroeMyriam FornageL. Adrienne CupplesCharles N. RotimiAlanna C. MorrisonDabeeru C. RaoRuth J. F. LoosNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

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