Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract.

Polyphenols contained within plant tissues are consumed in significant amounts in the human diet and are known to influence a number of biological processes. This study investigated the effects of an anthocyanin-rich berry-extract on glucose uptake by human intestinal Caco-2 cells. Acute exposure (1...

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Autores principales:	Fawaz Alzaid, Hoi-Man Cheung, Victor R Preedy, Paul A Sharp
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c604e581bf1d4c979fc1b74194bbcc11
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spelling	oai:doaj.org-article:c604e581bf1d4c979fc1b74194bbcc112021-11-18T08:46:52ZRegulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract.1932-620310.1371/journal.pone.0078932https://doaj.org/article/c604e581bf1d4c979fc1b74194bbcc112013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24236070/?tool=EBIhttps://doaj.org/toc/1932-6203Polyphenols contained within plant tissues are consumed in significant amounts in the human diet and are known to influence a number of biological processes. This study investigated the effects of an anthocyanin-rich berry-extract on glucose uptake by human intestinal Caco-2 cells. Acute exposure (15 min) to berry extract (0.125%, w/v) significantly decreased both sodium-dependent (Total uptake) and sodium-independent (facilitated uptake) ³H-D-glucose uptake. In longer-term studies, SGLT1 mRNA and GLUT2 mRNA expression were reduced significantly. Polyphenols are known to interact directly with glucose transporters to regulate the rate of glucose absorption. Our in vitro data support this mechanism and also suggest that berry flavonoids may modulate post-prandial glycaemia by decreasing glucose transporter expression. Further studies are warranted to investigate the longer term effects of berry flavonoids on the management of glycaemia in human volunteers.Fawaz AlzaidHoi-Man CheungVictor R PreedyPaul A SharpPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e78932 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fawaz Alzaid Hoi-Man Cheung Victor R Preedy Paul A Sharp Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract.
description	Polyphenols contained within plant tissues are consumed in significant amounts in the human diet and are known to influence a number of biological processes. This study investigated the effects of an anthocyanin-rich berry-extract on glucose uptake by human intestinal Caco-2 cells. Acute exposure (15 min) to berry extract (0.125%, w/v) significantly decreased both sodium-dependent (Total uptake) and sodium-independent (facilitated uptake) ³H-D-glucose uptake. In longer-term studies, SGLT1 mRNA and GLUT2 mRNA expression were reduced significantly. Polyphenols are known to interact directly with glucose transporters to regulate the rate of glucose absorption. Our in vitro data support this mechanism and also suggest that berry flavonoids may modulate post-prandial glycaemia by decreasing glucose transporter expression. Further studies are warranted to investigate the longer term effects of berry flavonoids on the management of glycaemia in human volunteers.
format	article
author	Fawaz Alzaid Hoi-Man Cheung Victor R Preedy Paul A Sharp
author_facet	Fawaz Alzaid Hoi-Man Cheung Victor R Preedy Paul A Sharp
author_sort	Fawaz Alzaid
title	Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract.
title_short	Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract.
title_full	Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract.
title_fullStr	Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract.
title_full_unstemmed	Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract.
title_sort	regulation of glucose transporter expression in human intestinal caco-2 cells following exposure to an anthocyanin-rich berry extract.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c604e581bf1d4c979fc1b74194bbcc11
work_keys_str_mv	AT fawazalzaid regulationofglucosetransporterexpressioninhumanintestinalcaco2cellsfollowingexposuretoananthocyaninrichberryextract AT hoimancheung regulationofglucosetransporterexpressioninhumanintestinalcaco2cellsfollowingexposuretoananthocyaninrichberryextract AT victorrpreedy regulationofglucosetransporterexpressioninhumanintestinalcaco2cellsfollowingexposuretoananthocyaninrichberryextract AT paulasharp regulationofglucosetransporterexpressioninhumanintestinalcaco2cellsfollowingexposuretoananthocyaninrichberryextract
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Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract.

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