Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells

Lipid metabolism has been linked to iNKT function largely as it impacts processing and presentation of lipids they recognize. Here the authors show that iNKT-intrinsic lipid biosynthesis is important for their function but is impaired in tumors, and its restoration with PPARγ agonist drugs promotes...

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Autores principales:	Sicheng Fu, Kaixin He, Chenxi Tian, Hua Sun, Chenwen Zhu, Shiyu Bai, Jiwei Liu, Qielan Wu, Di Xie, Ting Yue, Zhuxia Shen, Qingqing Dai, Xiaojun Yu, Shu Zhu, Gang Liu, Rongbin Zhou, Shengzhong Duan, Zhigang Tian, Tao Xu, Hua Wang, Li Bai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c605c340c0c94f1b8a85da028df9b400
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spelling	oai:doaj.org-article:c605c340c0c94f1b8a85da028df9b4002021-12-02T17:31:09ZImpaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells10.1038/s41467-020-14332-x2041-1723https://doaj.org/article/c605c340c0c94f1b8a85da028df9b4002020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14332-xhttps://doaj.org/toc/2041-1723Lipid metabolism has been linked to iNKT function largely as it impacts processing and presentation of lipids they recognize. Here the authors show that iNKT-intrinsic lipid biosynthesis is important for their function but is impaired in tumors, and its restoration with PPARγ agonist drugs promotes anti-tumor iNKT response.Sicheng FuKaixin HeChenxi TianHua SunChenwen ZhuShiyu BaiJiwei LiuQielan WuDi XieTing YueZhuxia ShenQingqing DaiXiaojun YuShu ZhuGang LiuRongbin ZhouShengzhong DuanZhigang TianTao XuHua WangLi BaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sicheng Fu Kaixin He Chenxi Tian Hua Sun Chenwen Zhu Shiyu Bai Jiwei Liu Qielan Wu Di Xie Ting Yue Zhuxia Shen Qingqing Dai Xiaojun Yu Shu Zhu Gang Liu Rongbin Zhou Shengzhong Duan Zhigang Tian Tao Xu Hua Wang Li Bai Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells
description	Lipid metabolism has been linked to iNKT function largely as it impacts processing and presentation of lipids they recognize. Here the authors show that iNKT-intrinsic lipid biosynthesis is important for their function but is impaired in tumors, and its restoration with PPARγ agonist drugs promotes anti-tumor iNKT response.
format	article
author	Sicheng Fu Kaixin He Chenxi Tian Hua Sun Chenwen Zhu Shiyu Bai Jiwei Liu Qielan Wu Di Xie Ting Yue Zhuxia Shen Qingqing Dai Xiaojun Yu Shu Zhu Gang Liu Rongbin Zhou Shengzhong Duan Zhigang Tian Tao Xu Hua Wang Li Bai
author_facet	Sicheng Fu Kaixin He Chenxi Tian Hua Sun Chenwen Zhu Shiyu Bai Jiwei Liu Qielan Wu Di Xie Ting Yue Zhuxia Shen Qingqing Dai Xiaojun Yu Shu Zhu Gang Liu Rongbin Zhou Shengzhong Duan Zhigang Tian Tao Xu Hua Wang Li Bai
author_sort	Sicheng Fu
title	Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells
title_short	Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells
title_full	Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells
title_fullStr	Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells
title_full_unstemmed	Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells
title_sort	impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral inkt cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c605c340c0c94f1b8a85da028df9b400
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Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells

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