Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells

Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells

Lipid metabolism has been linked to iNKT function largely as it impacts processing and presentation of lipids they recognize. Here the authors show that iNKT-intrinsic lipid biosynthesis is important for their function but is impaired in tumors, and its restoration with PPARγ agonist drugs promotes...

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Autores principales: Sicheng Fu, Kaixin He, Chenxi Tian, Hua Sun, Chenwen Zhu, Shiyu Bai, Jiwei Liu, Qielan Wu, Di Xie, Ting Yue, Zhuxia Shen, Qingqing Dai, Xiaojun Yu, Shu Zhu, Gang Liu, Rongbin Zhou, Shengzhong Duan, Zhigang Tian, Tao Xu, Hua Wang, Li Bai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/c605c340c0c94f1b8a85da028df9b400
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https://doaj.org/article/c605c340c0c94f1b8a85da028df9b400

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