Rebalancing gene haploinsufficiency in vivo by targeting chromatin

Deficit in transcription factor Tbx1 causes heart defects in humans and mice. Here the authors show that Tbx1 regulates gene expression by recruiting histone methyltransferases that affect chromatin marks, and that a drug inhibiting histone demethylation ameliorates the cardiovascular phenotype in T...

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Autores principales:	Filomena Gabriella Fulcoli, Monica Franzese, Xiangyang Liu, Zhen Zhang, Claudia Angelini, Antonio Baldini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c605fbaffcc6411d82a4fb0d53111f97
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spelling	oai:doaj.org-article:c605fbaffcc6411d82a4fb0d53111f972021-12-02T14:40:13ZRebalancing gene haploinsufficiency in vivo by targeting chromatin10.1038/ncomms116882041-1723https://doaj.org/article/c605fbaffcc6411d82a4fb0d53111f972016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11688https://doaj.org/toc/2041-1723Deficit in transcription factor Tbx1 causes heart defects in humans and mice. Here the authors show that Tbx1 regulates gene expression by recruiting histone methyltransferases that affect chromatin marks, and that a drug inhibiting histone demethylation ameliorates the cardiovascular phenotype in Tbx1 haploinsufficient or hypomorphic mice.Filomena Gabriella FulcoliMonica FranzeseXiangyang LiuZhen ZhangClaudia AngeliniAntonio BaldiniNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Filomena Gabriella Fulcoli Monica Franzese Xiangyang Liu Zhen Zhang Claudia Angelini Antonio Baldini Rebalancing gene haploinsufficiency in vivo by targeting chromatin
description	Deficit in transcription factor Tbx1 causes heart defects in humans and mice. Here the authors show that Tbx1 regulates gene expression by recruiting histone methyltransferases that affect chromatin marks, and that a drug inhibiting histone demethylation ameliorates the cardiovascular phenotype in Tbx1 haploinsufficient or hypomorphic mice.
format	article
author	Filomena Gabriella Fulcoli Monica Franzese Xiangyang Liu Zhen Zhang Claudia Angelini Antonio Baldini
author_facet	Filomena Gabriella Fulcoli Monica Franzese Xiangyang Liu Zhen Zhang Claudia Angelini Antonio Baldini
author_sort	Filomena Gabriella Fulcoli
title	Rebalancing gene haploinsufficiency in vivo by targeting chromatin
title_short	Rebalancing gene haploinsufficiency in vivo by targeting chromatin
title_full	Rebalancing gene haploinsufficiency in vivo by targeting chromatin
title_fullStr	Rebalancing gene haploinsufficiency in vivo by targeting chromatin
title_full_unstemmed	Rebalancing gene haploinsufficiency in vivo by targeting chromatin
title_sort	rebalancing gene haploinsufficiency in vivo by targeting chromatin
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c605fbaffcc6411d82a4fb0d53111f97
work_keys_str_mv	AT filomenagabriellafulcoli rebalancinggenehaploinsufficiencyinvivobytargetingchromatin AT monicafranzese rebalancinggenehaploinsufficiencyinvivobytargetingchromatin AT xiangyangliu rebalancinggenehaploinsufficiencyinvivobytargetingchromatin AT zhenzhang rebalancinggenehaploinsufficiencyinvivobytargetingchromatin AT claudiaangelini rebalancinggenehaploinsufficiencyinvivobytargetingchromatin AT antoniobaldini rebalancinggenehaploinsufficiencyinvivobytargetingchromatin
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Rebalancing gene haploinsufficiency in vivo by targeting chromatin

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