Composition and Associations of the Infant Gut Fungal Microbiota with Environmental Factors and Childhood Allergic Outcomes

Recent evidence suggests an immunomodulatory role for commensal fungi (mycobiota) in the gut, yet little is known about the composition and dynamics of early-life gut fungal communities. In this work, we show for the first time that the composition of the gut mycobiota of Canadian infants changes d...

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Autores principales:	Rozlyn C. T. Boutin, Hind Sbihi, Ryan J. McLaughlin, Aria S. Hahn, Kishori M. Konwar, Rachelle S. Loo, Darlene Dai, Charisse Petersen, Fiona S. L. Brinkman, Geoffrey L. Winsor, Malcolm R. Sears, Theo J. Moraes, Allan B. Becker, Meghan B. Azad, Piush J. Mandhane, Padmaja Subbarao, Stuart E. Turvey, B. Brett Finlay
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c60736f3131a420fa5fed1cfd3fd59f0
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spelling	oai:doaj.org-article:c60736f3131a420fa5fed1cfd3fd59f02021-11-03T21:15:04ZComposition and Associations of the Infant Gut Fungal Microbiota with Environmental Factors and Childhood Allergic Outcomes2150-751110.1128/mBio.03396-20https://doaj.org/article/c60736f3131a420fa5fed1cfd3fd59f02021-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03396-20https://doaj.org/toc/2150-7511 Recent evidence suggests an immunomodulatory role for commensal fungi (mycobiota) in the gut, yet little is known about the composition and dynamics of early-life gut fungal communities. In this work, we show for the first time that the composition of the gut mycobiota of Canadian infants changes dramatically over the course of the first year of life, is associated with environmental factors such as geographical location, diet, and season of birth, and can be used in conjunction with knowledge of a small number of key early-life factors to predict inhalant atopy status at age 5 years.Rozlyn C. T. BoutinHind SbihiRyan J. McLaughlinAria S. HahnKishori M. KonwarRachelle S. LooDarlene DaiCharisse PetersenFiona S. L. BrinkmanGeoffrey L. WinsorMalcolm R. SearsTheo J. MoraesAllan B. BeckerMeghan B. AzadPiush J. MandhanePadmaja SubbaraoStuart E. TurveyB. Brett FinlayAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Rozlyn C. T. Boutin Hind Sbihi Ryan J. McLaughlin Aria S. Hahn Kishori M. Konwar Rachelle S. Loo Darlene Dai Charisse Petersen Fiona S. L. Brinkman Geoffrey L. Winsor Malcolm R. Sears Theo J. Moraes Allan B. Becker Meghan B. Azad Piush J. Mandhane Padmaja Subbarao Stuart E. Turvey B. Brett Finlay Composition and Associations of the Infant Gut Fungal Microbiota with Environmental Factors and Childhood Allergic Outcomes
description	Recent evidence suggests an immunomodulatory role for commensal fungi (mycobiota) in the gut, yet little is known about the composition and dynamics of early-life gut fungal communities. In this work, we show for the first time that the composition of the gut mycobiota of Canadian infants changes dramatically over the course of the first year of life, is associated with environmental factors such as geographical location, diet, and season of birth, and can be used in conjunction with knowledge of a small number of key early-life factors to predict inhalant atopy status at age 5 years.
format	article
author	Rozlyn C. T. Boutin Hind Sbihi Ryan J. McLaughlin Aria S. Hahn Kishori M. Konwar Rachelle S. Loo Darlene Dai Charisse Petersen Fiona S. L. Brinkman Geoffrey L. Winsor Malcolm R. Sears Theo J. Moraes Allan B. Becker Meghan B. Azad Piush J. Mandhane Padmaja Subbarao Stuart E. Turvey B. Brett Finlay
author_facet	Rozlyn C. T. Boutin Hind Sbihi Ryan J. McLaughlin Aria S. Hahn Kishori M. Konwar Rachelle S. Loo Darlene Dai Charisse Petersen Fiona S. L. Brinkman Geoffrey L. Winsor Malcolm R. Sears Theo J. Moraes Allan B. Becker Meghan B. Azad Piush J. Mandhane Padmaja Subbarao Stuart E. Turvey B. Brett Finlay
author_sort	Rozlyn C. T. Boutin
title	Composition and Associations of the Infant Gut Fungal Microbiota with Environmental Factors and Childhood Allergic Outcomes
title_short	Composition and Associations of the Infant Gut Fungal Microbiota with Environmental Factors and Childhood Allergic Outcomes
title_full	Composition and Associations of the Infant Gut Fungal Microbiota with Environmental Factors and Childhood Allergic Outcomes
title_fullStr	Composition and Associations of the Infant Gut Fungal Microbiota with Environmental Factors and Childhood Allergic Outcomes
title_full_unstemmed	Composition and Associations of the Infant Gut Fungal Microbiota with Environmental Factors and Childhood Allergic Outcomes
title_sort	composition and associations of the infant gut fungal microbiota with environmental factors and childhood allergic outcomes
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/c60736f3131a420fa5fed1cfd3fd59f0
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Composition and Associations of the Infant Gut Fungal Microbiota with Environmental Factors and Childhood Allergic Outcomes

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