Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases

Chemically modified mRNA represents a unique, efficient, and straightforward approach to produce a class of biopharmaceutical agents. It has been already approved as a vaccination-based method for targeting SARS-CoV-2 virus. The COVID-19 pandemic has highlighted the prospect of synthetic modified mR...

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Autores principales:	Dana Elkhalifa, Menatallah Rayan, Ahmed T. Negmeldin, Abdelbary Elhissi, Ashraf Khalil
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Chemically Modified mRNA COVID-19 Vaccination Chronic diseases Cancer Diabetes Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c6076e1d48364f71a038e371a6ff5c8c
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spelling	oai:doaj.org-article:c6076e1d48364f71a038e371a6ff5c8c2021-12-04T04:33:04ZChemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases0753-332210.1016/j.biopha.2021.112385https://doaj.org/article/c6076e1d48364f71a038e371a6ff5c8c2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011690https://doaj.org/toc/0753-3322Chemically modified mRNA represents a unique, efficient, and straightforward approach to produce a class of biopharmaceutical agents. It has been already approved as a vaccination-based method for targeting SARS-CoV-2 virus. The COVID-19 pandemic has highlighted the prospect of synthetic modified mRNA to efficiently and safely combat various diseases. Recently, various optimization advances have been adopted to overcome the limitations associated with conventional gene therapeutics leading to wide-ranging applications in different disease conditions. This review sheds light on emerging directions of chemically modified mRNAs to prevent and treat widespread chronic diseases, including metabolic disorders, cancer vaccination and immunotherapy, musculoskeletal disorders, respiratory conditions, cardiovascular diseases, and liver diseases.Dana ElkhalifaMenatallah RayanAhmed T. NegmeldinAbdelbary ElhissiAshraf KhalilElsevierarticleChemically Modified mRNACOVID-19VaccinationChronic diseasesCancerDiabetesTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112385- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemically Modified mRNA COVID-19 Vaccination Chronic diseases Cancer Diabetes Therapeutics. Pharmacology RM1-950
spellingShingle	Chemically Modified mRNA COVID-19 Vaccination Chronic diseases Cancer Diabetes Therapeutics. Pharmacology RM1-950 Dana Elkhalifa Menatallah Rayan Ahmed T. Negmeldin Abdelbary Elhissi Ashraf Khalil Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
description	Chemically modified mRNA represents a unique, efficient, and straightforward approach to produce a class of biopharmaceutical agents. It has been already approved as a vaccination-based method for targeting SARS-CoV-2 virus. The COVID-19 pandemic has highlighted the prospect of synthetic modified mRNA to efficiently and safely combat various diseases. Recently, various optimization advances have been adopted to overcome the limitations associated with conventional gene therapeutics leading to wide-ranging applications in different disease conditions. This review sheds light on emerging directions of chemically modified mRNAs to prevent and treat widespread chronic diseases, including metabolic disorders, cancer vaccination and immunotherapy, musculoskeletal disorders, respiratory conditions, cardiovascular diseases, and liver diseases.
format	article
author	Dana Elkhalifa Menatallah Rayan Ahmed T. Negmeldin Abdelbary Elhissi Ashraf Khalil
author_facet	Dana Elkhalifa Menatallah Rayan Ahmed T. Negmeldin Abdelbary Elhissi Ashraf Khalil
author_sort	Dana Elkhalifa
title	Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
title_short	Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
title_full	Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
title_fullStr	Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
title_full_unstemmed	Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
title_sort	chemically modified mrna beyond covid-19: potential preventive and therapeutic applications for targeting chronic diseases
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/c6076e1d48364f71a038e371a6ff5c8c
work_keys_str_mv	AT danaelkhalifa chemicallymodifiedmrnabeyondcovid19potentialpreventiveandtherapeuticapplicationsfortargetingchronicdiseases AT menatallahrayan chemicallymodifiedmrnabeyondcovid19potentialpreventiveandtherapeuticapplicationsfortargetingchronicdiseases AT ahmedtnegmeldin chemicallymodifiedmrnabeyondcovid19potentialpreventiveandtherapeuticapplicationsfortargetingchronicdiseases AT abdelbaryelhissi chemicallymodifiedmrnabeyondcovid19potentialpreventiveandtherapeuticapplicationsfortargetingchronicdiseases AT ashrafkhalil chemicallymodifiedmrnabeyondcovid19potentialpreventiveandtherapeuticapplicationsfortargetingchronicdiseases
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Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases

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