The stability of flow velocity and intracoronary resistance in the intracoronary electrocardiogram-triggered pressure ratio

The stability of flow velocity and intracoronary resistance in the intracoronary electrocardiogram-triggered pressure ratio

Abstract Assessment of coronary artery lesions using the fractional flow reserve and instantaneous flow reserve (iFR) measurements has been found to reduce the incidence of further cardiovascular events. Here, we investigated differences in terms of coronary flow velocity and resistance within the a...

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Autores principales: Masafumi Nakayama, Nobuhiro Tanaka, Takashi Uchiyama, Takaaki Ohkawauchi, Yusuke Tsuboko, Kiyotaka Iwasaki, Yoshiaki Kawase, Hitoshi Matsuo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c6094e3c6ef440f8b497f7d2b2f11bae
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spelling oai:doaj.org-article:c6094e3c6ef440f8b497f7d2b2f11bae2021-12-02T15:22:56ZThe stability of flow velocity and intracoronary resistance in the intracoronary electrocardiogram-triggered pressure ratio10.1038/s41598-021-93181-02045-2322https://doaj.org/article/c6094e3c6ef440f8b497f7d2b2f11bae2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93181-0https://doaj.org/toc/2045-2322Abstract Assessment of coronary artery lesions using the fractional flow reserve and instantaneous flow reserve (iFR) measurements has been found to reduce the incidence of further cardiovascular events. Here, we investigated differences in terms of coronary flow velocity and resistance within the analysis interval between the iFR and the intracoronary electrocardiogram (IC-ECG)-triggered distal/aortic pressure (Pd/Pa) ratio (ICE-T). We enrolled 23 consecutive patients (n = 33 stenoses) who required coronary flow measurements. ICE-T was defined as the average Pd/Pa ratio in the period corresponding to the isoelectric line of the IC-ECG. We compared the index value, flow velocity, and intracoronary resistance during the analysis intervals of the iFR and the ICE-T, both at rest and under hyperemia. ICE-T values and ICE-T intracoronary resistance were both found to be significantly lower, whereas flow velocity was significantly higher than those of the iFR at both rest and under hyperemia (P < 0.001), and all fluctuations in ICE-T values were also significantly smaller than those in the iFR. In conclusion, the ICE-T appears theoretically superior to pressure-dependent indices for analyzing phases with low and stable resistance, without an increase in invasiveness.Masafumi NakayamaNobuhiro TanakaTakashi UchiyamaTakaaki OhkawauchiYusuke TsubokoKiyotaka IwasakiYoshiaki KawaseHitoshi MatsuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Masafumi Nakayama
Nobuhiro Tanaka
Takashi Uchiyama
Takaaki Ohkawauchi
Yusuke Tsuboko
Kiyotaka Iwasaki
Yoshiaki Kawase
Hitoshi Matsuo
The stability of flow velocity and intracoronary resistance in the intracoronary electrocardiogram-triggered pressure ratio
description Abstract Assessment of coronary artery lesions using the fractional flow reserve and instantaneous flow reserve (iFR) measurements has been found to reduce the incidence of further cardiovascular events. Here, we investigated differences in terms of coronary flow velocity and resistance within the analysis interval between the iFR and the intracoronary electrocardiogram (IC-ECG)-triggered distal/aortic pressure (Pd/Pa) ratio (ICE-T). We enrolled 23 consecutive patients (n = 33 stenoses) who required coronary flow measurements. ICE-T was defined as the average Pd/Pa ratio in the period corresponding to the isoelectric line of the IC-ECG. We compared the index value, flow velocity, and intracoronary resistance during the analysis intervals of the iFR and the ICE-T, both at rest and under hyperemia. ICE-T values and ICE-T intracoronary resistance were both found to be significantly lower, whereas flow velocity was significantly higher than those of the iFR at both rest and under hyperemia (P < 0.001), and all fluctuations in ICE-T values were also significantly smaller than those in the iFR. In conclusion, the ICE-T appears theoretically superior to pressure-dependent indices for analyzing phases with low and stable resistance, without an increase in invasiveness.
format article
author Masafumi Nakayama
Nobuhiro Tanaka
Takashi Uchiyama
Takaaki Ohkawauchi
Yusuke Tsuboko
Kiyotaka Iwasaki
Yoshiaki Kawase
Hitoshi Matsuo
author_facet Masafumi Nakayama
Nobuhiro Tanaka
Takashi Uchiyama
Takaaki Ohkawauchi
Yusuke Tsuboko
Kiyotaka Iwasaki
Yoshiaki Kawase
Hitoshi Matsuo
author_sort Masafumi Nakayama
title The stability of flow velocity and intracoronary resistance in the intracoronary electrocardiogram-triggered pressure ratio
title_short The stability of flow velocity and intracoronary resistance in the intracoronary electrocardiogram-triggered pressure ratio
title_full The stability of flow velocity and intracoronary resistance in the intracoronary electrocardiogram-triggered pressure ratio
title_fullStr The stability of flow velocity and intracoronary resistance in the intracoronary electrocardiogram-triggered pressure ratio
title_full_unstemmed The stability of flow velocity and intracoronary resistance in the intracoronary electrocardiogram-triggered pressure ratio
title_sort stability of flow velocity and intracoronary resistance in the intracoronary electrocardiogram-triggered pressure ratio
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c6094e3c6ef440f8b497f7d2b2f11bae
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