Regulated Cell Death in Urinary Malignancies

Urinary malignancies refer to a series of malignant tumors that occur in the urinary system and mainly include kidney, bladder, and prostate cancers. Although local or systemic radiotherapy and chemotherapy, immunotherapy, castration therapy and other methods have been applied to treat these disease...

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Autores principales:	Zhenyu Nie, Mei Chen, Yuanhui Gao, Denggao Huang, Hui Cao, Yanling Peng, Na Guo, Shufang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	urinary malignancies necroptosis pyroptosis ferroptosis neutrophil extracellular traps Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c60b5a5afcca4c259e1c2b47ac9a2f82
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spelling	oai:doaj.org-article:c60b5a5afcca4c259e1c2b47ac9a2f822021-11-12T05:32:07ZRegulated Cell Death in Urinary Malignancies2296-634X10.3389/fcell.2021.789004https://doaj.org/article/c60b5a5afcca4c259e1c2b47ac9a2f822021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.789004/fullhttps://doaj.org/toc/2296-634XUrinary malignancies refer to a series of malignant tumors that occur in the urinary system and mainly include kidney, bladder, and prostate cancers. Although local or systemic radiotherapy and chemotherapy, immunotherapy, castration therapy and other methods have been applied to treat these diseases, their high recurrence and metastasis rate remain problems for patients. With in-depth research on the pathogenesis of urinary malignant tumors, this work suggests that regulatory cell death (RCD) plays an important role in their occurrence and development. These RCD pathways are stimulated by various internal and external environmental factors and can induce cell death or permit cell survival under the control of various signal molecules, thereby affecting tumor progression or therapeutic efficacy. Among the previously reported RCD methods, necroptosis, pyroptosis, ferroptosis, and neutrophil extracellular traps (NETs) have attracted research attention. These modes transmit death signals through signal molecules, such as cysteine-aspartic proteases (caspase) family and tumor necrosis factor-α (TNF-α) that have a wide and profound influence on tumor proliferation or death and even change the sensitivity of tumor cells to therapy. This review discussed the effects of necroptosis, pyroptosis, ferroptosis, and NETs on kidney, bladder and prostate cancer and summarized the latest research and achievements in these fields. Future directions and possibility of improving the denouement of urinary system tumors treatment by targeting RCD therapy were also explored.Zhenyu NieMei ChenYuanhui GaoDenggao HuangHui CaoYanling PengNa GuoShufang ZhangFrontiers Media S.A.articleurinary malignanciesnecroptosispyroptosisferroptosisneutrophil extracellular trapsBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	urinary malignancies necroptosis pyroptosis ferroptosis neutrophil extracellular traps Biology (General) QH301-705.5
spellingShingle	urinary malignancies necroptosis pyroptosis ferroptosis neutrophil extracellular traps Biology (General) QH301-705.5 Zhenyu Nie Mei Chen Yuanhui Gao Denggao Huang Hui Cao Yanling Peng Na Guo Shufang Zhang Regulated Cell Death in Urinary Malignancies
description	Urinary malignancies refer to a series of malignant tumors that occur in the urinary system and mainly include kidney, bladder, and prostate cancers. Although local or systemic radiotherapy and chemotherapy, immunotherapy, castration therapy and other methods have been applied to treat these diseases, their high recurrence and metastasis rate remain problems for patients. With in-depth research on the pathogenesis of urinary malignant tumors, this work suggests that regulatory cell death (RCD) plays an important role in their occurrence and development. These RCD pathways are stimulated by various internal and external environmental factors and can induce cell death or permit cell survival under the control of various signal molecules, thereby affecting tumor progression or therapeutic efficacy. Among the previously reported RCD methods, necroptosis, pyroptosis, ferroptosis, and neutrophil extracellular traps (NETs) have attracted research attention. These modes transmit death signals through signal molecules, such as cysteine-aspartic proteases (caspase) family and tumor necrosis factor-α (TNF-α) that have a wide and profound influence on tumor proliferation or death and even change the sensitivity of tumor cells to therapy. This review discussed the effects of necroptosis, pyroptosis, ferroptosis, and NETs on kidney, bladder and prostate cancer and summarized the latest research and achievements in these fields. Future directions and possibility of improving the denouement of urinary system tumors treatment by targeting RCD therapy were also explored.
format	article
author	Zhenyu Nie Mei Chen Yuanhui Gao Denggao Huang Hui Cao Yanling Peng Na Guo Shufang Zhang
author_facet	Zhenyu Nie Mei Chen Yuanhui Gao Denggao Huang Hui Cao Yanling Peng Na Guo Shufang Zhang
author_sort	Zhenyu Nie
title	Regulated Cell Death in Urinary Malignancies
title_short	Regulated Cell Death in Urinary Malignancies
title_full	Regulated Cell Death in Urinary Malignancies
title_fullStr	Regulated Cell Death in Urinary Malignancies
title_full_unstemmed	Regulated Cell Death in Urinary Malignancies
title_sort	regulated cell death in urinary malignancies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c60b5a5afcca4c259e1c2b47ac9a2f82
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Regulated Cell Death in Urinary Malignancies

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