The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?

Alice Panariti, Giuseppe Miserocchi, Ilaria RivoltaDepartment of Experimental Medicine, University of Milano Bicocca, Monza, ItalyAbstract: Nanoparticles (NPs) are materials with overall dimensions in the nanoscale range. They have unique physicochemical properties, and have emerged as important pla...

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Autores principales:	Miserocchi G, Rivolta I, Panariti A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medical technology R855-855.5 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/c60d2a6c68e94b2f83a5a66ba67ffccb
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spelling	oai:doaj.org-article:c60d2a6c68e94b2f83a5a66ba67ffccb2021-12-02T01:40:11ZThe effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?1177-8903https://doaj.org/article/c60d2a6c68e94b2f83a5a66ba67ffccb2012-09-01T00:00:00Zhttp://www.dovepress.com/the-effect-of-nanoparticle-uptake-on-cellular-behavior-disrupting-or-e-a10945https://doaj.org/toc/1177-8903Alice Panariti, Giuseppe Miserocchi, Ilaria RivoltaDepartment of Experimental Medicine, University of Milano Bicocca, Monza, ItalyAbstract: Nanoparticles (NPs) are materials with overall dimensions in the nanoscale range. They have unique physicochemical properties, and have emerged as important players in current research in modern medicine. In the last few decades, several types of NPs and microparticles have been synthesized and proposed for use as contrast agents for diagnostics and imaging and for drug delivery; for example, in cancer therapy. Yet specific targeting that will improve their delivery still represents an unsolved challenge. The mechanism by which NPs enter the cell has important implications not only for their fate but also for their impact on biological systems. Several papers in the literature discuss the potential risks related to NP exposure, and more recently the concept that even sublethal doses of NPs may elicit a cell response has been proposed. In this review, we intend to present an overall view of cell mechanisms that may be perturbed by cell&ndash;NP interaction. Published data, in fact, emphasize that NPs should no longer be viewed only as simple carriers for biomedical applications, but that they can also play an active role in mediating biological effects.Keywords: nanoparticles, uptake, intracellular trafficking, bio compatibilityMiserocchi GRivolta IPanariti ADove Medical PressarticleMedical technologyR855-855.5Chemical technologyTP1-1185ENNanotechnology, Science and Applications, Vol 2012, Iss default, Pp 87-100 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5 Chemical technology TP1-1185
spellingShingle	Medical technology R855-855.5 Chemical technology TP1-1185 Miserocchi G Rivolta I Panariti A The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
description	Alice Panariti, Giuseppe Miserocchi, Ilaria RivoltaDepartment of Experimental Medicine, University of Milano Bicocca, Monza, ItalyAbstract: Nanoparticles (NPs) are materials with overall dimensions in the nanoscale range. They have unique physicochemical properties, and have emerged as important players in current research in modern medicine. In the last few decades, several types of NPs and microparticles have been synthesized and proposed for use as contrast agents for diagnostics and imaging and for drug delivery; for example, in cancer therapy. Yet specific targeting that will improve their delivery still represents an unsolved challenge. The mechanism by which NPs enter the cell has important implications not only for their fate but also for their impact on biological systems. Several papers in the literature discuss the potential risks related to NP exposure, and more recently the concept that even sublethal doses of NPs may elicit a cell response has been proposed. In this review, we intend to present an overall view of cell mechanisms that may be perturbed by cell&ndash;NP interaction. Published data, in fact, emphasize that NPs should no longer be viewed only as simple carriers for biomedical applications, but that they can also play an active role in mediating biological effects.Keywords: nanoparticles, uptake, intracellular trafficking, bio compatibility
format	article
author	Miserocchi G Rivolta I Panariti A
author_facet	Miserocchi G Rivolta I Panariti A
author_sort	Miserocchi G
title	The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
title_short	The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
title_full	The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
title_fullStr	The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
title_full_unstemmed	The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
title_sort	effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/c60d2a6c68e94b2f83a5a66ba67ffccb
work_keys_str_mv	AT miserocchig theeffectofnanoparticleuptakeoncellularbehaviordisruptingorenablingfunctions AT rivoltai theeffectofnanoparticleuptakeoncellularbehaviordisruptingorenablingfunctions AT panaritia theeffectofnanoparticleuptakeoncellularbehaviordisruptingorenablingfunctions AT miserocchig effectofnanoparticleuptakeoncellularbehaviordisruptingorenablingfunctions AT rivoltai effectofnanoparticleuptakeoncellularbehaviordisruptingorenablingfunctions AT panaritia effectofnanoparticleuptakeoncellularbehaviordisruptingorenablingfunctions
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The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?

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