The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?

Alice Panariti, Giuseppe Miserocchi, Ilaria RivoltaDepartment of Experimental Medicine, University of Milano Bicocca, Monza, ItalyAbstract: Nanoparticles (NPs) are materials with overall dimensions in the nanoscale range. They have unique physicochemical properties, and have emerged as important pla...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Miserocchi G, Rivolta I, Panariti A
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://doaj.org/article/c60d2a6c68e94b2f83a5a66ba67ffccb
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:c60d2a6c68e94b2f83a5a66ba67ffccb
record_format dspace
spelling oai:doaj.org-article:c60d2a6c68e94b2f83a5a66ba67ffccb2021-12-02T01:40:11ZThe effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?1177-8903https://doaj.org/article/c60d2a6c68e94b2f83a5a66ba67ffccb2012-09-01T00:00:00Zhttp://www.dovepress.com/the-effect-of-nanoparticle-uptake-on-cellular-behavior-disrupting-or-e-a10945https://doaj.org/toc/1177-8903Alice Panariti, Giuseppe Miserocchi, Ilaria RivoltaDepartment of Experimental Medicine, University of Milano Bicocca, Monza, ItalyAbstract: Nanoparticles (NPs) are materials with overall dimensions in the nanoscale range. They have unique physicochemical properties, and have emerged as important players in current research in modern medicine. In the last few decades, several types of NPs and microparticles have been synthesized and proposed for use as contrast agents for diagnostics and imaging and for drug delivery; for example, in cancer therapy. Yet specific targeting that will improve their delivery still represents an unsolved challenge. The mechanism by which NPs enter the cell has important implications not only for their fate but also for their impact on biological systems. Several papers in the literature discuss the potential risks related to NP exposure, and more recently the concept that even sublethal doses of NPs may elicit a cell response has been proposed. In this review, we intend to present an overall view of cell mechanisms that may be perturbed by cell–NP interaction. Published data, in fact, emphasize that NPs should no longer be viewed only as simple carriers for biomedical applications, but that they can also play an active role in mediating biological effects.Keywords: nanoparticles, uptake, intracellular trafficking, bio compatibilityMiserocchi GRivolta IPanariti ADove Medical PressarticleMedical technologyR855-855.5Chemical technologyTP1-1185ENNanotechnology, Science and Applications, Vol 2012, Iss default, Pp 87-100 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medical technology
R855-855.5
Chemical technology
TP1-1185
spellingShingle Medical technology
R855-855.5
Chemical technology
TP1-1185
Miserocchi G
Rivolta I
Panariti A
The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
description Alice Panariti, Giuseppe Miserocchi, Ilaria RivoltaDepartment of Experimental Medicine, University of Milano Bicocca, Monza, ItalyAbstract: Nanoparticles (NPs) are materials with overall dimensions in the nanoscale range. They have unique physicochemical properties, and have emerged as important players in current research in modern medicine. In the last few decades, several types of NPs and microparticles have been synthesized and proposed for use as contrast agents for diagnostics and imaging and for drug delivery; for example, in cancer therapy. Yet specific targeting that will improve their delivery still represents an unsolved challenge. The mechanism by which NPs enter the cell has important implications not only for their fate but also for their impact on biological systems. Several papers in the literature discuss the potential risks related to NP exposure, and more recently the concept that even sublethal doses of NPs may elicit a cell response has been proposed. In this review, we intend to present an overall view of cell mechanisms that may be perturbed by cell–NP interaction. Published data, in fact, emphasize that NPs should no longer be viewed only as simple carriers for biomedical applications, but that they can also play an active role in mediating biological effects.Keywords: nanoparticles, uptake, intracellular trafficking, bio compatibility
format article
author Miserocchi G
Rivolta I
Panariti A
author_facet Miserocchi G
Rivolta I
Panariti A
author_sort Miserocchi G
title The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
title_short The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
title_full The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
title_fullStr The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
title_full_unstemmed The effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
title_sort effect of nanoparticle uptake on cellular behavior: disrupting or enabling functions?
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/c60d2a6c68e94b2f83a5a66ba67ffccb
work_keys_str_mv AT miserocchig theeffectofnanoparticleuptakeoncellularbehaviordisruptingorenablingfunctions
AT rivoltai theeffectofnanoparticleuptakeoncellularbehaviordisruptingorenablingfunctions
AT panaritia theeffectofnanoparticleuptakeoncellularbehaviordisruptingorenablingfunctions
AT miserocchig effectofnanoparticleuptakeoncellularbehaviordisruptingorenablingfunctions
AT rivoltai effectofnanoparticleuptakeoncellularbehaviordisruptingorenablingfunctions
AT panaritia effectofnanoparticleuptakeoncellularbehaviordisruptingorenablingfunctions
_version_ 1718402983601897472