Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

Dietary fibers and SCFAs can exert a protective effect against respiratory syncytial virus (RSV). Here, the authors report that microbiota-derived acetate protects mice against RSV infection via GPR43- mediated type 1 interferon response induction in the lungs.

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Autores principales:	Krist Helen Antunes, José Luís Fachi, Rosemeire de Paula, Emanuelle Fraga da Silva, Laís Passariello Pral, Adara Áurea dos Santos, Greicy Brisa Malaquias Dias, José Eduardo Vargas, Renato Puga, Fabiana Quoos Mayer, Fábio Maito, Carlos R. Zárate-Bladés, Nadim J. Ajami, Marcella Ramos Sant’Ana, Thamiris Candreva, Hosana Gomes Rodrigues, Marcio Schmiele, Maria Teresa Pedrosa Silva Clerici, José Luiz Proença-Modena, Angélica Thomas Vieira, Charles R. Mackay, Daniel Mansur, Mauricio T. Caballero, Jacqui Marzec, Jianying Li, Xuting Wang, Douglas Bell, Fernando P. Polack, Steven R. Kleeberger, Renato T. Stein, Marco Aurélio Ramirez Vinolo, Ana Paula Duarte de Souza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c60e76919412482d9d4459cf276f5674
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spelling	oai:doaj.org-article:c60e76919412482d9d4459cf276f56742021-12-02T17:01:38ZMicrobiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response10.1038/s41467-019-11152-62041-1723https://doaj.org/article/c60e76919412482d9d4459cf276f56742019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11152-6https://doaj.org/toc/2041-1723Dietary fibers and SCFAs can exert a protective effect against respiratory syncytial virus (RSV). Here, the authors report that microbiota-derived acetate protects mice against RSV infection via GPR43- mediated type 1 interferon response induction in the lungs.Krist Helen AntunesJosé Luís FachiRosemeire de PaulaEmanuelle Fraga da SilvaLaís Passariello PralAdara Áurea dos SantosGreicy Brisa Malaquias DiasJosé Eduardo VargasRenato PugaFabiana Quoos MayerFábio MaitoCarlos R. Zárate-BladésNadim J. AjamiMarcella Ramos Sant’AnaThamiris CandrevaHosana Gomes RodriguesMarcio SchmieleMaria Teresa Pedrosa Silva ClericiJosé Luiz Proença-ModenaAngélica Thomas VieiraCharles R. MackayDaniel MansurMauricio T. CaballeroJacqui MarzecJianying LiXuting WangDouglas BellFernando P. PolackSteven R. KleebergerRenato T. SteinMarco Aurélio Ramirez VinoloAna Paula Duarte de SouzaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krist Helen Antunes José Luís Fachi Rosemeire de Paula Emanuelle Fraga da Silva Laís Passariello Pral Adara Áurea dos Santos Greicy Brisa Malaquias Dias José Eduardo Vargas Renato Puga Fabiana Quoos Mayer Fábio Maito Carlos R. Zárate-Bladés Nadim J. Ajami Marcella Ramos Sant’Ana Thamiris Candreva Hosana Gomes Rodrigues Marcio Schmiele Maria Teresa Pedrosa Silva Clerici José Luiz Proença-Modena Angélica Thomas Vieira Charles R. Mackay Daniel Mansur Mauricio T. Caballero Jacqui Marzec Jianying Li Xuting Wang Douglas Bell Fernando P. Polack Steven R. Kleeberger Renato T. Stein Marco Aurélio Ramirez Vinolo Ana Paula Duarte de Souza Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response
description	Dietary fibers and SCFAs can exert a protective effect against respiratory syncytial virus (RSV). Here, the authors report that microbiota-derived acetate protects mice against RSV infection via GPR43- mediated type 1 interferon response induction in the lungs.
format	article
author	Krist Helen Antunes José Luís Fachi Rosemeire de Paula Emanuelle Fraga da Silva Laís Passariello Pral Adara Áurea dos Santos Greicy Brisa Malaquias Dias José Eduardo Vargas Renato Puga Fabiana Quoos Mayer Fábio Maito Carlos R. Zárate-Bladés Nadim J. Ajami Marcella Ramos Sant’Ana Thamiris Candreva Hosana Gomes Rodrigues Marcio Schmiele Maria Teresa Pedrosa Silva Clerici José Luiz Proença-Modena Angélica Thomas Vieira Charles R. Mackay Daniel Mansur Mauricio T. Caballero Jacqui Marzec Jianying Li Xuting Wang Douglas Bell Fernando P. Polack Steven R. Kleeberger Renato T. Stein Marco Aurélio Ramirez Vinolo Ana Paula Duarte de Souza
author_facet	Krist Helen Antunes José Luís Fachi Rosemeire de Paula Emanuelle Fraga da Silva Laís Passariello Pral Adara Áurea dos Santos Greicy Brisa Malaquias Dias José Eduardo Vargas Renato Puga Fabiana Quoos Mayer Fábio Maito Carlos R. Zárate-Bladés Nadim J. Ajami Marcella Ramos Sant’Ana Thamiris Candreva Hosana Gomes Rodrigues Marcio Schmiele Maria Teresa Pedrosa Silva Clerici José Luiz Proença-Modena Angélica Thomas Vieira Charles R. Mackay Daniel Mansur Mauricio T. Caballero Jacqui Marzec Jianying Li Xuting Wang Douglas Bell Fernando P. Polack Steven R. Kleeberger Renato T. Stein Marco Aurélio Ramirez Vinolo Ana Paula Duarte de Souza
author_sort	Krist Helen Antunes
title	Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response
title_short	Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response
title_full	Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response
title_fullStr	Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response
title_full_unstemmed	Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response
title_sort	microbiota-derived acetate protects against respiratory syncytial virus infection through a gpr43-type 1 interferon response
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c60e76919412482d9d4459cf276f5674
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Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

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