Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility

Angiogenesis requires dynamic endothelial rearrangements and relative position changes within the vascular tubes. Here the authors show that a PI3K/NUAK1/MYPT1/MLCP pathway regulates actomyosin contractility in endothelial cells and cellular rearrangement during vascular patterning.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ana Angulo-Urarte, Pedro Casado, Sandra D. Castillo, Piotr Kobialka, Maria Paraskevi Kotini, Ana M. Figueiredo, Pau Castel, Vinothini Rajeeve, Maria Milà-Guasch, Jaime Millan, Cora Wiesner, Helena Serra, Laia Muixi, Oriol Casanovas, Francesc Viñals, Markus Affolter, Holger Gerhardt, Stephan Huveneers, Heinz-Georg Belting, Pedro R. Cutillas, Mariona Graupera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c60f6787e577415b9bffa0b9f6b7962a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c60f6787e577415b9bffa0b9f6b7962a
record_format	dspace
spelling	oai:doaj.org-article:c60f6787e577415b9bffa0b9f6b7962a2021-12-02T14:39:05ZEndothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility10.1038/s41467-018-07172-32041-1723https://doaj.org/article/c60f6787e577415b9bffa0b9f6b7962a2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07172-3https://doaj.org/toc/2041-1723Angiogenesis requires dynamic endothelial rearrangements and relative position changes within the vascular tubes. Here the authors show that a PI3K/NUAK1/MYPT1/MLCP pathway regulates actomyosin contractility in endothelial cells and cellular rearrangement during vascular patterning.Ana Angulo-UrartePedro CasadoSandra D. CastilloPiotr KobialkaMaria Paraskevi KotiniAna M. FigueiredoPau CastelVinothini RajeeveMaria Milà-GuaschJaime MillanCora WiesnerHelena SerraLaia MuixiOriol CasanovasFrancesc ViñalsMarkus AffolterHolger GerhardtStephan HuveneersHeinz-Georg BeltingPedro R. CutillasMariona GrauperaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ana Angulo-Urarte Pedro Casado Sandra D. Castillo Piotr Kobialka Maria Paraskevi Kotini Ana M. Figueiredo Pau Castel Vinothini Rajeeve Maria Milà-Guasch Jaime Millan Cora Wiesner Helena Serra Laia Muixi Oriol Casanovas Francesc Viñals Markus Affolter Holger Gerhardt Stephan Huveneers Heinz-Georg Belting Pedro R. Cutillas Mariona Graupera Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility
description	Angiogenesis requires dynamic endothelial rearrangements and relative position changes within the vascular tubes. Here the authors show that a PI3K/NUAK1/MYPT1/MLCP pathway regulates actomyosin contractility in endothelial cells and cellular rearrangement during vascular patterning.
format	article
author	Ana Angulo-Urarte Pedro Casado Sandra D. Castillo Piotr Kobialka Maria Paraskevi Kotini Ana M. Figueiredo Pau Castel Vinothini Rajeeve Maria Milà-Guasch Jaime Millan Cora Wiesner Helena Serra Laia Muixi Oriol Casanovas Francesc Viñals Markus Affolter Holger Gerhardt Stephan Huveneers Heinz-Georg Belting Pedro R. Cutillas Mariona Graupera
author_facet	Ana Angulo-Urarte Pedro Casado Sandra D. Castillo Piotr Kobialka Maria Paraskevi Kotini Ana M. Figueiredo Pau Castel Vinothini Rajeeve Maria Milà-Guasch Jaime Millan Cora Wiesner Helena Serra Laia Muixi Oriol Casanovas Francesc Viñals Markus Affolter Holger Gerhardt Stephan Huveneers Heinz-Georg Belting Pedro R. Cutillas Mariona Graupera
author_sort	Ana Angulo-Urarte
title	Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility
title_short	Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility
title_full	Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility
title_fullStr	Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility
title_full_unstemmed	Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility
title_sort	endothelial cell rearrangements during vascular patterning require pi3-kinase-mediated inhibition of actomyosin contractility
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c60f6787e577415b9bffa0b9f6b7962a
work_keys_str_mv	AT anaangulourarte endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT pedrocasado endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT sandradcastillo endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT piotrkobialka endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT mariaparaskevikotini endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT anamfigueiredo endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT paucastel endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT vinothinirajeeve endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT mariamilaguasch endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT jaimemillan endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT corawiesner endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT helenaserra endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT laiamuixi endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT oriolcasanovas endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT francescvinals endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT markusaffolter endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT holgergerhardt endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT stephanhuveneers endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT heinzgeorgbelting endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT pedrorcutillas endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility AT marionagraupera endothelialcellrearrangementsduringvascularpatterningrequirepi3kinasemediatedinhibitionofactomyosincontractility
_version_	1718390736940957696

Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility

Ejemplares similares