Evaluation of the Effectiveness and Safety of the BNT162b2 COVID-19 Vaccine in the Vaccination Campaign among the Health Workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Health workers, especially those in patient-facing roles, had a significantly increased risk of COVID-19 infection, having serious outcomes, and risking spreading the virus to patients and staff. Vaccination campaign planning suggests allocating initial supplies of BNT162b2 vaccine to health workers...

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Autores principales:	Domenico Pascucci, Mario Cesare Nurchis, Martina Sapienza, Francesco Castrini, Flavia Beccia, Floriana D’Ambrosio, Adriano Grossi, Carolina Castagna, Angelo Maria Pezzullo, Maurizio Zega, Domenico Staiti, Francesco Maria De Simone, Nadia Mores, Andrea Cambieri, Giuseppe Vetrugno, Gianfranco Damiani, Patrizia Laurenti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	effectiveness safety health workers vaccine vaccination campaign COVID-19 Medicine R
Acceso en línea:	https://doaj.org/article/c61112319957410e82ff89c2d292f85b
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spelling	oai:doaj.org-article:c61112319957410e82ff89c2d292f85b2021-11-11T16:14:42ZEvaluation of the Effectiveness and Safety of the BNT162b2 COVID-19 Vaccine in the Vaccination Campaign among the Health Workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS10.3390/ijerph1821110981660-46011661-7827https://doaj.org/article/c61112319957410e82ff89c2d292f85b2021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11098https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Health workers, especially those in patient-facing roles, had a significantly increased risk of COVID-19 infection, having serious outcomes, and risking spreading the virus to patients and staff. Vaccination campaign planning suggests allocating initial supplies of BNT162b2 vaccine to health workers given the importance of early protection to safeguard the continuity of care to patients. The aim of the study is to assess the effectiveness and safety of BNT162b2 vaccine among the health workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS (FPG). The retrospective cohort study was conducted among health staff working at the FPG. Vaccination data were collected from hospital records. The primary end points were vaccine effectiveness and safety. A total of 6649 health workers were included, of whom 5162 received injections. There were 14 cases of COVID-19 with onset at least 14 days after the second dose among vaccinated health workers and 45 cases among unvaccinated ones. BNT162b2 was 91.5% effective against COVID-19 (95% credible interval, 84.7% to 95.3%). The safety profile of BNT162b2 vaccine consisted of short-term, non-serious events. The promotion and boost of the COVID-19 vaccination campaign represents a key public health measure useful to curb the spread of the pandemic especially in vulnerable contexts, such as hospitals, where health workers carry out a paramount role for the entire community, and requires further protection with a possible booster dose in view of autumn-winter 2021.Domenico PascucciMario Cesare NurchisMartina SapienzaFrancesco CastriniFlavia BecciaFloriana D’AmbrosioAdriano GrossiCarolina CastagnaAngelo Maria PezzulloMaurizio ZegaDomenico StaitiFrancesco Maria De SimoneNadia MoresAndrea CambieriGiuseppe VetrugnoGianfranco DamianiPatrizia LaurentiMDPI AGarticleeffectivenesssafetyhealth workersvaccinevaccination campaignCOVID-19MedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11098, p 11098 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	effectiveness safety health workers vaccine vaccination campaign COVID-19 Medicine R
spellingShingle	effectiveness safety health workers vaccine vaccination campaign COVID-19 Medicine R Domenico Pascucci Mario Cesare Nurchis Martina Sapienza Francesco Castrini Flavia Beccia Floriana D’Ambrosio Adriano Grossi Carolina Castagna Angelo Maria Pezzullo Maurizio Zega Domenico Staiti Francesco Maria De Simone Nadia Mores Andrea Cambieri Giuseppe Vetrugno Gianfranco Damiani Patrizia Laurenti Evaluation of the Effectiveness and Safety of the BNT162b2 COVID-19 Vaccine in the Vaccination Campaign among the Health Workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS
description	Health workers, especially those in patient-facing roles, had a significantly increased risk of COVID-19 infection, having serious outcomes, and risking spreading the virus to patients and staff. Vaccination campaign planning suggests allocating initial supplies of BNT162b2 vaccine to health workers given the importance of early protection to safeguard the continuity of care to patients. The aim of the study is to assess the effectiveness and safety of BNT162b2 vaccine among the health workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS (FPG). The retrospective cohort study was conducted among health staff working at the FPG. Vaccination data were collected from hospital records. The primary end points were vaccine effectiveness and safety. A total of 6649 health workers were included, of whom 5162 received injections. There were 14 cases of COVID-19 with onset at least 14 days after the second dose among vaccinated health workers and 45 cases among unvaccinated ones. BNT162b2 was 91.5% effective against COVID-19 (95% credible interval, 84.7% to 95.3%). The safety profile of BNT162b2 vaccine consisted of short-term, non-serious events. The promotion and boost of the COVID-19 vaccination campaign represents a key public health measure useful to curb the spread of the pandemic especially in vulnerable contexts, such as hospitals, where health workers carry out a paramount role for the entire community, and requires further protection with a possible booster dose in view of autumn-winter 2021.
format	article
author	Domenico Pascucci Mario Cesare Nurchis Martina Sapienza Francesco Castrini Flavia Beccia Floriana D’Ambrosio Adriano Grossi Carolina Castagna Angelo Maria Pezzullo Maurizio Zega Domenico Staiti Francesco Maria De Simone Nadia Mores Andrea Cambieri Giuseppe Vetrugno Gianfranco Damiani Patrizia Laurenti
author_facet	Domenico Pascucci Mario Cesare Nurchis Martina Sapienza Francesco Castrini Flavia Beccia Floriana D’Ambrosio Adriano Grossi Carolina Castagna Angelo Maria Pezzullo Maurizio Zega Domenico Staiti Francesco Maria De Simone Nadia Mores Andrea Cambieri Giuseppe Vetrugno Gianfranco Damiani Patrizia Laurenti
author_sort	Domenico Pascucci
title	Evaluation of the Effectiveness and Safety of the BNT162b2 COVID-19 Vaccine in the Vaccination Campaign among the Health Workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS
title_short	Evaluation of the Effectiveness and Safety of the BNT162b2 COVID-19 Vaccine in the Vaccination Campaign among the Health Workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS
title_full	Evaluation of the Effectiveness and Safety of the BNT162b2 COVID-19 Vaccine in the Vaccination Campaign among the Health Workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS
title_fullStr	Evaluation of the Effectiveness and Safety of the BNT162b2 COVID-19 Vaccine in the Vaccination Campaign among the Health Workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS
title_full_unstemmed	Evaluation of the Effectiveness and Safety of the BNT162b2 COVID-19 Vaccine in the Vaccination Campaign among the Health Workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS
title_sort	evaluation of the effectiveness and safety of the bnt162b2 covid-19 vaccine in the vaccination campaign among the health workers of fondazione policlinico universitario agostino gemelli irccs
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c61112319957410e82ff89c2d292f85b
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Evaluation of the Effectiveness and Safety of the BNT162b2 COVID-19 Vaccine in the Vaccination Campaign among the Health Workers of Fondazione Policlinico Universitario Agostino Gemelli IRCCS

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