α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors

Morphine, the main component of opium, is a commonly used analgesic in clinical practice, but its abuse potential limits its clinical application. Nicotinic acetylcholine receptors (nAChRs) in the mesolimbic circuitry play an important role in the rewarding effects of abused drugs. Previous studies...

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Autores principales:	Xiaodan Li, Jian Xiong, Baojian Zhang, Dongting Zhangsun, Sulan Luo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	morphine addiction α6β2∗ nAChRs α-conotoxin TxIB CPP behavioral changes Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c61152096c374d8d904be81ba82dbd84
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spelling	oai:doaj.org-article:c61152096c374d8d904be81ba82dbd842021-12-03T16:56:47Zα-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors1663-981210.3389/fphar.2021.772990https://doaj.org/article/c61152096c374d8d904be81ba82dbd842021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.772990/fullhttps://doaj.org/toc/1663-9812Morphine, the main component of opium, is a commonly used analgesic in clinical practice, but its abuse potential limits its clinical application. Nicotinic acetylcholine receptors (nAChRs) in the mesolimbic circuitry play an important role in the rewarding effects of abused drugs. Previous studies have showed that α6β2* (* designated other subunits) nAChRs are mainly distributed in dopaminergic neurons in the midbrain area, which regulates the release of dopamine. So α6β2* nAChRs are regarded as a new target to treat drug abuse. α-Conotoxin TxIB was discovered in our lab, which is the most selective ligand to inhibit α6β2* nAChRs only. Antagonists of α6β2* nAChRs decreased nicotine, cocaine, and ethanol rewarding effects previously. However, their role in morphine addiction has not been reported so far. Thus, it is worth evaluating the effect of α-conotoxin TxIB on the morphine-induced conditioned place preference (CPP) and its behavioral changes in mice. Our results showed that TxIB inhibited expression and acquisition of morphine-induced CPP and did not produce a rewarding effect by itself. Moreover, repeated injections of TxIB have no effect on learning, memory, locomotor activity, and anxiety-like behavior. Therefore, blocking α6/α3β2β3 nAChRs inhibits the development of morphine-induced CPP. α-Conotoxin TxIB may be a potentially useful compound to mitigate the acquisition and/or retention of drug-context associations.Xiaodan LiJian XiongBaojian ZhangDongting ZhangsunDongting ZhangsunSulan LuoSulan LuoFrontiers Media S.A.articlemorphine addictionα6β2∗ nAChRsα-conotoxin TxIBCPPbehavioral changesTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	morphine addiction α6β2∗ nAChRs α-conotoxin TxIB CPP behavioral changes Therapeutics. Pharmacology RM1-950
spellingShingle	morphine addiction α6β2∗ nAChRs α-conotoxin TxIB CPP behavioral changes Therapeutics. Pharmacology RM1-950 Xiaodan Li Jian Xiong Baojian Zhang Dongting Zhangsun Dongting Zhangsun Sulan Luo Sulan Luo α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors
description	Morphine, the main component of opium, is a commonly used analgesic in clinical practice, but its abuse potential limits its clinical application. Nicotinic acetylcholine receptors (nAChRs) in the mesolimbic circuitry play an important role in the rewarding effects of abused drugs. Previous studies have showed that α6β2* (* designated other subunits) nAChRs are mainly distributed in dopaminergic neurons in the midbrain area, which regulates the release of dopamine. So α6β2* nAChRs are regarded as a new target to treat drug abuse. α-Conotoxin TxIB was discovered in our lab, which is the most selective ligand to inhibit α6β2* nAChRs only. Antagonists of α6β2* nAChRs decreased nicotine, cocaine, and ethanol rewarding effects previously. However, their role in morphine addiction has not been reported so far. Thus, it is worth evaluating the effect of α-conotoxin TxIB on the morphine-induced conditioned place preference (CPP) and its behavioral changes in mice. Our results showed that TxIB inhibited expression and acquisition of morphine-induced CPP and did not produce a rewarding effect by itself. Moreover, repeated injections of TxIB have no effect on learning, memory, locomotor activity, and anxiety-like behavior. Therefore, blocking α6/α3β2β3 nAChRs inhibits the development of morphine-induced CPP. α-Conotoxin TxIB may be a potentially useful compound to mitigate the acquisition and/or retention of drug-context associations.
format	article
author	Xiaodan Li Jian Xiong Baojian Zhang Dongting Zhangsun Dongting Zhangsun Sulan Luo Sulan Luo
author_facet	Xiaodan Li Jian Xiong Baojian Zhang Dongting Zhangsun Dongting Zhangsun Sulan Luo Sulan Luo
author_sort	Xiaodan Li
title	α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors
title_short	α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors
title_full	α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors
title_fullStr	α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors
title_full_unstemmed	α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors
title_sort	α-conotoxin txib inhibits development of morphine-induced conditioned place preference in mice via blocking α6β2* nicotinic acetylcholine receptors
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c61152096c374d8d904be81ba82dbd84
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α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice via Blocking α6β2* Nicotinic Acetylcholine Receptors

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