Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

The transcription factor SREBP is a well-studied and major regulator of sterol and fatty acid metabolism. Here, the authors used haploid genetic screens to identify the Golgi-resident protein SPRING as a new modulator of SREBP by regulating the level of functional SREBP cleavage-activating protein (...

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Autores principales:	Anke Loregger, Matthijs Raaben, Joppe Nieuwenhuis, Josephine M. E. Tan, Lucas T. Jae, Lisa G. van den Hengel, Sebastian Hendrix, Marlene van den Berg, Saskia Scheij, Ji-Ying Song, Ivo J. Huijbers, Lona J. Kroese, Roelof Ottenhoff, Michel van Weeghel, Bart van de Sluis, Thijn Brummelkamp, Noam Zelcer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c61323181ab94658810dfa8228b715af
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spelling	oai:doaj.org-article:c61323181ab94658810dfa8228b715af2021-12-02T14:41:25ZHaploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism10.1038/s41467-020-14811-12041-1723https://doaj.org/article/c61323181ab94658810dfa8228b715af2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14811-1https://doaj.org/toc/2041-1723The transcription factor SREBP is a well-studied and major regulator of sterol and fatty acid metabolism. Here, the authors used haploid genetic screens to identify the Golgi-resident protein SPRING as a new modulator of SREBP by regulating the level of functional SREBP cleavage-activating protein (SCAP).Anke LoreggerMatthijs RaabenJoppe NieuwenhuisJosephine M. E. TanLucas T. JaeLisa G. van den HengelSebastian HendrixMarlene van den BergSaskia ScheijJi-Ying SongIvo J. HuijbersLona J. KroeseRoelof OttenhoffMichel van WeeghelBart van de SluisThijn BrummelkampNoam ZelcerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anke Loregger Matthijs Raaben Joppe Nieuwenhuis Josephine M. E. Tan Lucas T. Jae Lisa G. van den Hengel Sebastian Hendrix Marlene van den Berg Saskia Scheij Ji-Ying Song Ivo J. Huijbers Lona J. Kroese Roelof Ottenhoff Michel van Weeghel Bart van de Sluis Thijn Brummelkamp Noam Zelcer Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism
description	The transcription factor SREBP is a well-studied and major regulator of sterol and fatty acid metabolism. Here, the authors used haploid genetic screens to identify the Golgi-resident protein SPRING as a new modulator of SREBP by regulating the level of functional SREBP cleavage-activating protein (SCAP).
format	article
author	Anke Loregger Matthijs Raaben Joppe Nieuwenhuis Josephine M. E. Tan Lucas T. Jae Lisa G. van den Hengel Sebastian Hendrix Marlene van den Berg Saskia Scheij Ji-Ying Song Ivo J. Huijbers Lona J. Kroese Roelof Ottenhoff Michel van Weeghel Bart van de Sluis Thijn Brummelkamp Noam Zelcer
author_facet	Anke Loregger Matthijs Raaben Joppe Nieuwenhuis Josephine M. E. Tan Lucas T. Jae Lisa G. van den Hengel Sebastian Hendrix Marlene van den Berg Saskia Scheij Ji-Ying Song Ivo J. Huijbers Lona J. Kroese Roelof Ottenhoff Michel van Weeghel Bart van de Sluis Thijn Brummelkamp Noam Zelcer
author_sort	Anke Loregger
title	Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism
title_short	Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism
title_full	Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism
title_fullStr	Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism
title_full_unstemmed	Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism
title_sort	haploid genetic screens identify spring/c12orf49 as a determinant of srebp signaling and cholesterol metabolism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c61323181ab94658810dfa8228b715af
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Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

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