Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients

Proximal spinal muscular atrophy (SMA) is a rare progressive, life limiting genetic motor neuron disease. While promising causal therapies are available, meaningful prognostic biomarkers for therapeutic monitoring are missing. We demonstrate handheld Multispectral Optoacoustic Tomography (MSOT) as a...

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Autores principales:	Adrian P. Regensburger, Alexandra L. Wagner, Vera Danko, Jörg Jüngert, Anna Federle, Daniel Klett, Stephanie Schuessler, Adrian Buehler, Markus F. Neurath, Andreas Roos, Hanns Lochmüller, Joachim Woelfle, Regina Trollmann, Maximilian J. Waldner, Ferdinand Knieling
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Optoacoustics Photoacoustics Multispectral optoacoustic tomography Spinal muscular atrophie Physics QC1-999 Acoustics. Sound QC221-246 Optics. Light QC350-467
Acceso en línea:	https://doaj.org/article/c614589ba8734c80966616dca9c32959
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spelling	oai:doaj.org-article:c614589ba8734c80966616dca9c329592021-11-20T05:06:00ZMultispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients2213-597910.1016/j.pacs.2021.100315https://doaj.org/article/c614589ba8734c80966616dca9c329592022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213597921000744https://doaj.org/toc/2213-5979Proximal spinal muscular atrophy (SMA) is a rare progressive, life limiting genetic motor neuron disease. While promising causal therapies are available, meaningful prognostic biomarkers for therapeutic monitoring are missing. We demonstrate handheld Multispectral Optoacoustic Tomography (MSOT) as a novel non-invasive imaging approach to visualize and quantify muscle wasting in pediatric SMA. While MSOT signals were distributed homogeneously in muscles of healthy volunteers (HVs), SMA patients showed moth-eaten optoacoustic signal patterns. Further signal quantification revealed greatest differences between groups at the isosbestic point for hemoglobin (SWL 800 nm). The SWL 800 nm signal intensities further correlated with clinical phenotype tested by standard motor outcome measures. Therefore, handheld MSOT could enable non-invasive assessment of disease burden in SMA patients.Adrian P. RegensburgerAlexandra L. WagnerVera DankoJörg JüngertAnna FederleDaniel KlettStephanie SchuesslerAdrian BuehlerMarkus F. NeurathAndreas RoosHanns LochmüllerJoachim WoelfleRegina TrollmannMaximilian J. WaldnerFerdinand KnielingElsevierarticleOptoacousticsPhotoacousticsMultispectral optoacoustic tomographySpinal muscular atrophiePhysicsQC1-999Acoustics. SoundQC221-246Optics. LightQC350-467ENPhotoacoustics, Vol 25, Iss , Pp 100315- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Optoacoustics Photoacoustics Multispectral optoacoustic tomography Spinal muscular atrophie Physics QC1-999 Acoustics. Sound QC221-246 Optics. Light QC350-467
spellingShingle	Optoacoustics Photoacoustics Multispectral optoacoustic tomography Spinal muscular atrophie Physics QC1-999 Acoustics. Sound QC221-246 Optics. Light QC350-467 Adrian P. Regensburger Alexandra L. Wagner Vera Danko Jörg Jüngert Anna Federle Daniel Klett Stephanie Schuessler Adrian Buehler Markus F. Neurath Andreas Roos Hanns Lochmüller Joachim Woelfle Regina Trollmann Maximilian J. Waldner Ferdinand Knieling Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients
description	Proximal spinal muscular atrophy (SMA) is a rare progressive, life limiting genetic motor neuron disease. While promising causal therapies are available, meaningful prognostic biomarkers for therapeutic monitoring are missing. We demonstrate handheld Multispectral Optoacoustic Tomography (MSOT) as a novel non-invasive imaging approach to visualize and quantify muscle wasting in pediatric SMA. While MSOT signals were distributed homogeneously in muscles of healthy volunteers (HVs), SMA patients showed moth-eaten optoacoustic signal patterns. Further signal quantification revealed greatest differences between groups at the isosbestic point for hemoglobin (SWL 800 nm). The SWL 800 nm signal intensities further correlated with clinical phenotype tested by standard motor outcome measures. Therefore, handheld MSOT could enable non-invasive assessment of disease burden in SMA patients.
format	article
author	Adrian P. Regensburger Alexandra L. Wagner Vera Danko Jörg Jüngert Anna Federle Daniel Klett Stephanie Schuessler Adrian Buehler Markus F. Neurath Andreas Roos Hanns Lochmüller Joachim Woelfle Regina Trollmann Maximilian J. Waldner Ferdinand Knieling
author_facet	Adrian P. Regensburger Alexandra L. Wagner Vera Danko Jörg Jüngert Anna Federle Daniel Klett Stephanie Schuessler Adrian Buehler Markus F. Neurath Andreas Roos Hanns Lochmüller Joachim Woelfle Regina Trollmann Maximilian J. Waldner Ferdinand Knieling
author_sort	Adrian P. Regensburger
title	Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients
title_short	Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients
title_full	Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients
title_fullStr	Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients
title_full_unstemmed	Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients
title_sort	multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/c614589ba8734c80966616dca9c32959
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Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients

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