A conserved enhancer regulates Il9 expression in multiple lineages

Interleukin-9 (IL-9) is important for allergy, autoimmunity and tumor immunity, but how its expression is regulated is unclear. Here the authors show the essential function of an enhancer, CNS-25 in mouse and CNS-18 in human, for IL-9 expression, with the deletion of this enhancer severely hampering...

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Autores principales:	Byunghee Koh, Amina Abdul Qayum, Rajneesh Srivastava, Yongyao Fu, Benjamin J. Ulrich, Sarath Chandra Janga, Mark H. Kaplan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c61519e680244108827ba600002853d5
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spelling	oai:doaj.org-article:c61519e680244108827ba600002853d52021-12-02T15:34:28ZA conserved enhancer regulates Il9 expression in multiple lineages10.1038/s41467-018-07202-02041-1723https://doaj.org/article/c61519e680244108827ba600002853d52018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07202-0https://doaj.org/toc/2041-1723Interleukin-9 (IL-9) is important for allergy, autoimmunity and tumor immunity, but how its expression is regulated is unclear. Here the authors show the essential function of an enhancer, CNS-25 in mouse and CNS-18 in human, for IL-9 expression, with the deletion of this enhancer severely hampering IL-9 production in mice or human cells.Byunghee KohAmina Abdul QayumRajneesh SrivastavaYongyao FuBenjamin J. UlrichSarath Chandra JangaMark H. KaplanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Byunghee Koh Amina Abdul Qayum Rajneesh Srivastava Yongyao Fu Benjamin J. Ulrich Sarath Chandra Janga Mark H. Kaplan A conserved enhancer regulates Il9 expression in multiple lineages
description	Interleukin-9 (IL-9) is important for allergy, autoimmunity and tumor immunity, but how its expression is regulated is unclear. Here the authors show the essential function of an enhancer, CNS-25 in mouse and CNS-18 in human, for IL-9 expression, with the deletion of this enhancer severely hampering IL-9 production in mice or human cells.
format	article
author	Byunghee Koh Amina Abdul Qayum Rajneesh Srivastava Yongyao Fu Benjamin J. Ulrich Sarath Chandra Janga Mark H. Kaplan
author_facet	Byunghee Koh Amina Abdul Qayum Rajneesh Srivastava Yongyao Fu Benjamin J. Ulrich Sarath Chandra Janga Mark H. Kaplan
author_sort	Byunghee Koh
title	A conserved enhancer regulates Il9 expression in multiple lineages
title_short	A conserved enhancer regulates Il9 expression in multiple lineages
title_full	A conserved enhancer regulates Il9 expression in multiple lineages
title_fullStr	A conserved enhancer regulates Il9 expression in multiple lineages
title_full_unstemmed	A conserved enhancer regulates Il9 expression in multiple lineages
title_sort	conserved enhancer regulates il9 expression in multiple lineages
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c61519e680244108827ba600002853d5
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A conserved enhancer regulates Il9 expression in multiple lineages

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