Use of serotonin reuptake inhibitors and risk of subsequent bone loss in a nationwide population-based cohort study

Abstract This study examined whether the use of SRIs is associated with an increased risk of bone loss using a nested case–control design with a nationwide population–based cohort in Korea. Using the Korean National Health Screening Cohort, subjects newly diagnosed with osteoporosis or osteopenia (n...

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Autores principales:	Sunyoung Kang, Minkyung Han, Chun Il Park, Inkyung Jung, Eun Hwa Kim, Young Jun Boo, Jee In Kang, Se Joo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c616ac3be0114918833a5333462de6a0
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spelling	oai:doaj.org-article:c616ac3be0114918833a5333462de6a02021-12-02T16:32:02ZUse of serotonin reuptake inhibitors and risk of subsequent bone loss in a nationwide population-based cohort study10.1038/s41598-021-92821-92045-2322https://doaj.org/article/c616ac3be0114918833a5333462de6a02021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92821-9https://doaj.org/toc/2045-2322Abstract This study examined whether the use of SRIs is associated with an increased risk of bone loss using a nested case–control design with a nationwide population–based cohort in Korea. Using the Korean National Health Screening Cohort, subjects newly diagnosed with osteoporosis or osteopenia (n = 55,799) were matched with controls (n = 278,995) at a ratio of 1:5. We stratified the participants by their time-dependent use of SRIs and sex and controlled for various confounders, including lifestyle habits, laboratory data, and comorbidities. Conditional logistic regression showed that both recent and former users of SRIs had an increased risk of subsequent bone loss compared with non-users: men [recent users: odds ratio (OR) 1.35, 95% confidential interval (CI) 1.20, 1.53; former-users: OR 1.10, 95% CI 1.01, 1.20]; women (recent users: OR 1.38, 95% CI 1.28–1.48; former-users: OR 1.07, 95% CI 1.02, 1.21). The use of SRIs was associated with an increased risk of bone loss in both men and women. In particular, the association was stronger in recent users. These findings provide population-level evidence for the risk of bone loss associated with SRI exposure and highlight the importance of monitoring the bone health of SRI users.Sunyoung KangMinkyung HanChun Il ParkInkyung JungEun Hwa KimYoung Jun BooJee In KangSe Joo KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sunyoung Kang Minkyung Han Chun Il Park Inkyung Jung Eun Hwa Kim Young Jun Boo Jee In Kang Se Joo Kim Use of serotonin reuptake inhibitors and risk of subsequent bone loss in a nationwide population-based cohort study
description	Abstract This study examined whether the use of SRIs is associated with an increased risk of bone loss using a nested case–control design with a nationwide population–based cohort in Korea. Using the Korean National Health Screening Cohort, subjects newly diagnosed with osteoporosis or osteopenia (n = 55,799) were matched with controls (n = 278,995) at a ratio of 1:5. We stratified the participants by their time-dependent use of SRIs and sex and controlled for various confounders, including lifestyle habits, laboratory data, and comorbidities. Conditional logistic regression showed that both recent and former users of SRIs had an increased risk of subsequent bone loss compared with non-users: men [recent users: odds ratio (OR) 1.35, 95% confidential interval (CI) 1.20, 1.53; former-users: OR 1.10, 95% CI 1.01, 1.20]; women (recent users: OR 1.38, 95% CI 1.28–1.48; former-users: OR 1.07, 95% CI 1.02, 1.21). The use of SRIs was associated with an increased risk of bone loss in both men and women. In particular, the association was stronger in recent users. These findings provide population-level evidence for the risk of bone loss associated with SRI exposure and highlight the importance of monitoring the bone health of SRI users.
format	article
author	Sunyoung Kang Minkyung Han Chun Il Park Inkyung Jung Eun Hwa Kim Young Jun Boo Jee In Kang Se Joo Kim
author_facet	Sunyoung Kang Minkyung Han Chun Il Park Inkyung Jung Eun Hwa Kim Young Jun Boo Jee In Kang Se Joo Kim
author_sort	Sunyoung Kang
title	Use of serotonin reuptake inhibitors and risk of subsequent bone loss in a nationwide population-based cohort study
title_short	Use of serotonin reuptake inhibitors and risk of subsequent bone loss in a nationwide population-based cohort study
title_full	Use of serotonin reuptake inhibitors and risk of subsequent bone loss in a nationwide population-based cohort study
title_fullStr	Use of serotonin reuptake inhibitors and risk of subsequent bone loss in a nationwide population-based cohort study
title_full_unstemmed	Use of serotonin reuptake inhibitors and risk of subsequent bone loss in a nationwide population-based cohort study
title_sort	use of serotonin reuptake inhibitors and risk of subsequent bone loss in a nationwide population-based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c616ac3be0114918833a5333462de6a0
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Use of serotonin reuptake inhibitors and risk of subsequent bone loss in a nationwide population-based cohort study

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