SOME FEATURES OF GENOME STRUCTURE AND EVOLUTION OF MYCOBACTERIUM TUBERCULOSIS

Abstract. Mycobacterium tuberculosis complex includes both human pathogens (M. tuberculosis, M. africanum and M. canettii), rodent paghogens (M. microti), as well as Mycobacterium bovis with wide range of hosts and related M. caprae and M. pinnipedii. In spite of phenotypic and host differences thes...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	I. V. Mokrousov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	molecular evolution mycobacterium tuberculosis genome is6110 deletions polymorphism Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/c621f10768284cf19e0d230df4ecd533
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c621f10768284cf19e0d230df4ecd533
record_format	dspace
spelling	oai:doaj.org-article:c621f10768284cf19e0d230df4ecd5332021-11-22T07:09:45ZSOME FEATURES OF GENOME STRUCTURE AND EVOLUTION OF MYCOBACTERIUM TUBERCULOSIS2220-76192313-739810.15789/2220-7619-2011-3-211-220https://doaj.org/article/c621f10768284cf19e0d230df4ecd5332014-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/49https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. Mycobacterium tuberculosis complex includes both human pathogens (M. tuberculosis, M. africanum and M. canettii), rodent paghogens (M. microti), as well as Mycobacterium bovis with wide range of hosts and related M. caprae and M. pinnipedii. In spite of phenotypic and host differences these species present a highly homogeneous genospecies with 99.7–99.9% of genome homology and extremely low level of horizontal gene transfer. Recent genetic research in the last decade permitted to revisit and revise old and new dogmas about genome and evolution of M. tuberculosis. In particular, a classical theory about bovine origin of human tuberculosis during domestication process was rejected. It was demonstrated that genomes of the related species of M. tuberculosis complex evolved through large unidirectional deletions leading to origin of M. tuberculosis sensu stricto, M. bovis and other species (M. canettii, M. microti, M. pinnipedii, M. caprae) from the same progenitor species. Large deletions influence the pathogenic potential of different clonal lineages within M. tuberculosis. At the same time, genetic variation within the short time frames is achieved via changes in the repetitive DNA and transposition of the insertion sequences IS6110 across the genome. Furthermore, M. tuberculosis may adapt to the selective pressure of the host immune system and antituberculosis drugs via specific point mutations. In the last few years a higher level of SNP variation between closely related strains was demonstrated with opens new perspectives for full-genome and multilocus sequence typing of M. tuberculosis.I. V. MokrousovSankt-Peterburg : NIIÈM imeni Pasteraarticlemolecular evolutionmycobacterium tuberculosisgenomeis6110deletionspolymorphismInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 1, Iss 3, Pp 211-220 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	molecular evolution mycobacterium tuberculosis genome is6110 deletions polymorphism Infectious and parasitic diseases RC109-216
spellingShingle	molecular evolution mycobacterium tuberculosis genome is6110 deletions polymorphism Infectious and parasitic diseases RC109-216 I. V. Mokrousov SOME FEATURES OF GENOME STRUCTURE AND EVOLUTION OF MYCOBACTERIUM TUBERCULOSIS
description	Abstract. Mycobacterium tuberculosis complex includes both human pathogens (M. tuberculosis, M. africanum and M. canettii), rodent paghogens (M. microti), as well as Mycobacterium bovis with wide range of hosts and related M. caprae and M. pinnipedii. In spite of phenotypic and host differences these species present a highly homogeneous genospecies with 99.7–99.9% of genome homology and extremely low level of horizontal gene transfer. Recent genetic research in the last decade permitted to revisit and revise old and new dogmas about genome and evolution of M. tuberculosis. In particular, a classical theory about bovine origin of human tuberculosis during domestication process was rejected. It was demonstrated that genomes of the related species of M. tuberculosis complex evolved through large unidirectional deletions leading to origin of M. tuberculosis sensu stricto, M. bovis and other species (M. canettii, M. microti, M. pinnipedii, M. caprae) from the same progenitor species. Large deletions influence the pathogenic potential of different clonal lineages within M. tuberculosis. At the same time, genetic variation within the short time frames is achieved via changes in the repetitive DNA and transposition of the insertion sequences IS6110 across the genome. Furthermore, M. tuberculosis may adapt to the selective pressure of the host immune system and antituberculosis drugs via specific point mutations. In the last few years a higher level of SNP variation between closely related strains was demonstrated with opens new perspectives for full-genome and multilocus sequence typing of M. tuberculosis.
format	article
author	I. V. Mokrousov
author_facet	I. V. Mokrousov
author_sort	I. V. Mokrousov
title	SOME FEATURES OF GENOME STRUCTURE AND EVOLUTION OF MYCOBACTERIUM TUBERCULOSIS
title_short	SOME FEATURES OF GENOME STRUCTURE AND EVOLUTION OF MYCOBACTERIUM TUBERCULOSIS
title_full	SOME FEATURES OF GENOME STRUCTURE AND EVOLUTION OF MYCOBACTERIUM TUBERCULOSIS
title_fullStr	SOME FEATURES OF GENOME STRUCTURE AND EVOLUTION OF MYCOBACTERIUM TUBERCULOSIS
title_full_unstemmed	SOME FEATURES OF GENOME STRUCTURE AND EVOLUTION OF MYCOBACTERIUM TUBERCULOSIS
title_sort	some features of genome structure and evolution of mycobacterium tuberculosis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/c621f10768284cf19e0d230df4ecd533
work_keys_str_mv	AT ivmokrousov somefeaturesofgenomestructureandevolutionofmycobacteriumtuberculosis
_version_	1718418067718930432

SOME FEATURES OF GENOME STRUCTURE AND EVOLUTION OF MYCOBACTERIUM TUBERCULOSIS

Ejemplares similares