Dietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy

Abstract The screening rate of diabetic retinopathy (DR) is low despite the importance of early diagnosis. We investigated the predictive value of dietary glutamic acid and aspartic acid for diagnosis of DR using the Korea National Diabetes Program cohort study. The 2067 patients with type 2 diabete...

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Autores principales:	So Young Park, Jieun Kim, Jung Il Son, Sang Youl Rhee, Do-Yeon Kim, Suk Chon, Hyunjung Lim, Jeong-Taek Woo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c6286b3f6b824c5f8a8698bd8556d5f0
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spelling	oai:doaj.org-article:c6286b3f6b824c5f8a8698bd8556d5f02021-12-02T14:23:23ZDietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy10.1038/s41598-021-83165-52045-2322https://doaj.org/article/c6286b3f6b824c5f8a8698bd8556d5f02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83165-5https://doaj.org/toc/2045-2322Abstract The screening rate of diabetic retinopathy (DR) is low despite the importance of early diagnosis. We investigated the predictive value of dietary glutamic acid and aspartic acid for diagnosis of DR using the Korea National Diabetes Program cohort study. The 2067 patients with type 2 diabetes without DR were included. The baseline intakes of energy, glutamic acid and aspartic acid were assessed using a 3-day food records. The risk of DR incidence based on intake of glutamic acid and aspartic acid was analyzed. The DR group was older, and had higher HbA1c, longer DM duration, lower education level and income than non-DR group (all p < 0.05). The intake of total energy, glutamic acid and aspartic acid were lower in DR group than non-DR group (p = 0.010, p = 0.025 and p = 0.042, respectively). There was no difference in the risk of developing DR according to the intake of glutamic acid and ascorbic acid. But, aspartic acid intake had a negative correlation with PDR. Hence, the intake of glutamic acid and aspartic acid did not affect in DR incidence. However, lower aspartic acid intake affected the PDR incidence.So Young ParkJieun KimJung Il SonSang Youl RheeDo-Yeon KimSuk ChonHyunjung LimJeong-Taek WooNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q So Young Park Jieun Kim Jung Il Son Sang Youl Rhee Do-Yeon Kim Suk Chon Hyunjung Lim Jeong-Taek Woo Dietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy
description	Abstract The screening rate of diabetic retinopathy (DR) is low despite the importance of early diagnosis. We investigated the predictive value of dietary glutamic acid and aspartic acid for diagnosis of DR using the Korea National Diabetes Program cohort study. The 2067 patients with type 2 diabetes without DR were included. The baseline intakes of energy, glutamic acid and aspartic acid were assessed using a 3-day food records. The risk of DR incidence based on intake of glutamic acid and aspartic acid was analyzed. The DR group was older, and had higher HbA1c, longer DM duration, lower education level and income than non-DR group (all p < 0.05). The intake of total energy, glutamic acid and aspartic acid were lower in DR group than non-DR group (p = 0.010, p = 0.025 and p = 0.042, respectively). There was no difference in the risk of developing DR according to the intake of glutamic acid and ascorbic acid. But, aspartic acid intake had a negative correlation with PDR. Hence, the intake of glutamic acid and aspartic acid did not affect in DR incidence. However, lower aspartic acid intake affected the PDR incidence.
format	article
author	So Young Park Jieun Kim Jung Il Son Sang Youl Rhee Do-Yeon Kim Suk Chon Hyunjung Lim Jeong-Taek Woo
author_facet	So Young Park Jieun Kim Jung Il Son Sang Youl Rhee Do-Yeon Kim Suk Chon Hyunjung Lim Jeong-Taek Woo
author_sort	So Young Park
title	Dietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy
title_short	Dietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy
title_full	Dietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy
title_fullStr	Dietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy
title_full_unstemmed	Dietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy
title_sort	dietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c6286b3f6b824c5f8a8698bd8556d5f0
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Dietary glutamic acid and aspartic acid as biomarkers for predicting diabetic retinopathy

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