STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION
Abstract. The purpose of our study was to investigate whether S27P and -15С→T single nucleotide polymorphisms of the IL3 gene are associated with susceptibility to bronchial asthma (BA) in Russians living in the Central-Chernozem region of Russia. DNA samples obtained from 216 unrelated patients wit...
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SPb RAACI
2014
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oai:doaj.org-article:c62a0e6fe1da438ab19858fda753fe4b2021-11-18T08:03:42ZSTUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION1563-06252313-741X10.15789/1563-0625-2006-5-6-731-736https://doaj.org/article/c62a0e6fe1da438ab19858fda753fe4b2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/587https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The purpose of our study was to investigate whether S27P and -15С→T single nucleotide polymorphisms of the IL3 gene are associated with susceptibility to bronchial asthma (BA) in Russians living in the Central-Chernozem region of Russia. DNA samples obtained from 216 unrelated patients with BA and 214 healthy controls were typed for S27P and -15С→T polymorphisms in the IL3 gene by PCR-RFLP methods. Gender-based differences in the distribution of IL3 genotypes have been revealed between controls and patients with asthma. Both S27P and -15С→T polymorphisms were found to associate with common susceptibility to BA predominantly in females (p=0,05). Studied genetic variants of IL3 gene were in strong linkage disequilibrium with each other (p<0,0001). Further studies are required to investigate phenotypic expression of S27P and -15С→T polymorphisms of IL3 gene and to clarify their roles in the pathogenesis of bronchial asthma.A. V. PolonikovV. P. IvanovD. A. BeluginI. V. KhoroshayaM. A. SolodilovaV. I. PanfilovSPb RAACIarticlebronchial asthmail-3single nucleotide polymorphismsgenetic susceptibilityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 5-6, Pp 731-736 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
RU |
| topic |
bronchial asthma il-3 single nucleotide polymorphisms genetic susceptibility Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
bronchial asthma il-3 single nucleotide polymorphisms genetic susceptibility Immunologic diseases. Allergy RC581-607 A. V. Polonikov V. P. Ivanov D. A. Belugin I. V. Khoroshaya M. A. Solodilova V. I. Panfilov STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION |
| description |
Abstract. The purpose of our study was to investigate whether S27P and -15С→T single nucleotide polymorphisms of the IL3 gene are associated with susceptibility to bronchial asthma (BA) in Russians living in the Central-Chernozem region of Russia. DNA samples obtained from 216 unrelated patients with BA and 214 healthy controls were typed for S27P and -15С→T polymorphisms in the IL3 gene by PCR-RFLP methods. Gender-based differences in the distribution of IL3 genotypes have been revealed between controls and patients with asthma. Both S27P and -15С→T polymorphisms were found to associate with common susceptibility to BA predominantly in females (p=0,05). Studied genetic variants of IL3 gene were in strong linkage disequilibrium with each other (p<0,0001). Further studies are required to investigate phenotypic expression of S27P and -15С→T polymorphisms of IL3 gene and to clarify their roles in the pathogenesis of bronchial asthma. |
| format |
article |
| author |
A. V. Polonikov V. P. Ivanov D. A. Belugin I. V. Khoroshaya M. A. Solodilova V. I. Panfilov |
| author_facet |
A. V. Polonikov V. P. Ivanov D. A. Belugin I. V. Khoroshaya M. A. Solodilova V. I. Panfilov |
| author_sort |
A. V. Polonikov |
| title |
STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION |
| title_short |
STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION |
| title_full |
STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION |
| title_fullStr |
STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION |
| title_full_unstemmed |
STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION |
| title_sort |
studying associations of two common s27p and -15с→t polymorphisms of the interleukin-3 gene with development of allergic and non-allergic bronchial asthma in russians from the central-chernozem region |
| publisher |
SPb RAACI |
| publishDate |
2014 |
| url |
https://doaj.org/article/c62a0e6fe1da438ab19858fda753fe4b |
| work_keys_str_mv |
AT avpolonikov studyingassociationsoftwocommons27pand15stpolymorphismsoftheinterleukin3genewithdevelopmentofallergicandnonallergicbronchialasthmainrussiansfromthecentralchernozemregion AT vpivanov studyingassociationsoftwocommons27pand15stpolymorphismsoftheinterleukin3genewithdevelopmentofallergicandnonallergicbronchialasthmainrussiansfromthecentralchernozemregion AT dabelugin studyingassociationsoftwocommons27pand15stpolymorphismsoftheinterleukin3genewithdevelopmentofallergicandnonallergicbronchialasthmainrussiansfromthecentralchernozemregion AT ivkhoroshaya studyingassociationsoftwocommons27pand15stpolymorphismsoftheinterleukin3genewithdevelopmentofallergicandnonallergicbronchialasthmainrussiansfromthecentralchernozemregion AT masolodilova studyingassociationsoftwocommons27pand15stpolymorphismsoftheinterleukin3genewithdevelopmentofallergicandnonallergicbronchialasthmainrussiansfromthecentralchernozemregion AT vipanfilov studyingassociationsoftwocommons27pand15stpolymorphismsoftheinterleukin3genewithdevelopmentofallergicandnonallergicbronchialasthmainrussiansfromthecentralchernozemregion |
| _version_ |
1718422507100307456 |