Nano-vectors for efficient liver specific gene transfer

Atul Pathak1, Suresh P Vyas2, Kailash C Gupta11Nucleic Acids Research Laboratory, Institute of Genomics and Integrative Biology, Delhi &nbsp;University Campus, Delhi, India 2Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, (M.P.), IndiaAbstract: Recent progre...

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Autores principales:	Atul Pathak, Suresh P Vyas, Kailash C Gupta
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c62af6ace5944ce9bda7a1b76f852676
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spelling	oai:doaj.org-article:c62af6ace5944ce9bda7a1b76f8526762021-12-02T00:43:24ZNano-vectors for efficient liver specific gene transfer1176-91141178-2013https://doaj.org/article/c62af6ace5944ce9bda7a1b76f8526762008-03-01T00:00:00Zhttp://www.dovepress.com/nano-vectors-for-efficient-liver-specific-gene-transfer-a737https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Atul Pathak1, Suresh P Vyas2, Kailash C Gupta11Nucleic Acids Research Laboratory, Institute of Genomics and Integrative Biology, Delhi &nbsp;University Campus, Delhi, India 2Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, (M.P.), IndiaAbstract: Recent progress in nanotechnology has triggered the site specific drug/gene delivery research and gained wide acknowledgment in contemporary DNA therapeutics. Amongst various organs, liver plays a crucial role in various body functions and in addition, the site is a primary location of metastatic tumor growth. In past few years, a plethora of nano-vectors have been developed and investigated to target liver associated cells through receptor mediated endocytosis. This emerging paradigm in cellular drug/gene delivery provides promising approach to eradicate genetic as well as acquired diseases affecting the liver. The present review provides a comprehensive overview of potential of various delivery systems, viz., lipoplexes, liposomes, polyplexes, nanoparticles and so forth to selectively relocate foreign therapeutic DNA into liver specific cell type via the receptor mediated endocytosis. Various receptors like asialoglycoprotein receptors (ASGP-R) provide unique opportunity to target liver parenchymal cells. The results obtained so far reveal tremendous promise and offer enormous options to develop novel DNAbased pharmaceuticals for liver disorders in near future.Keywords: hepatocytes, nanoparticles, liposomes, nucleic acids, asialoglycoprotein receptors Atul PathakSuresh P VyasKailash C GuptaDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 1, Pp 31-49 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Atul Pathak Suresh P Vyas Kailash C Gupta Nano-vectors for efficient liver specific gene transfer
description	Atul Pathak1, Suresh P Vyas2, Kailash C Gupta11Nucleic Acids Research Laboratory, Institute of Genomics and Integrative Biology, Delhi &nbsp;University Campus, Delhi, India 2Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishwavidyalaya, Sagar, (M.P.), IndiaAbstract: Recent progress in nanotechnology has triggered the site specific drug/gene delivery research and gained wide acknowledgment in contemporary DNA therapeutics. Amongst various organs, liver plays a crucial role in various body functions and in addition, the site is a primary location of metastatic tumor growth. In past few years, a plethora of nano-vectors have been developed and investigated to target liver associated cells through receptor mediated endocytosis. This emerging paradigm in cellular drug/gene delivery provides promising approach to eradicate genetic as well as acquired diseases affecting the liver. The present review provides a comprehensive overview of potential of various delivery systems, viz., lipoplexes, liposomes, polyplexes, nanoparticles and so forth to selectively relocate foreign therapeutic DNA into liver specific cell type via the receptor mediated endocytosis. Various receptors like asialoglycoprotein receptors (ASGP-R) provide unique opportunity to target liver parenchymal cells. The results obtained so far reveal tremendous promise and offer enormous options to develop novel DNAbased pharmaceuticals for liver disorders in near future.Keywords: hepatocytes, nanoparticles, liposomes, nucleic acids, asialoglycoprotein receptors
format	article
author	Atul Pathak Suresh P Vyas Kailash C Gupta
author_facet	Atul Pathak Suresh P Vyas Kailash C Gupta
author_sort	Atul Pathak
title	Nano-vectors for efficient liver specific gene transfer
title_short	Nano-vectors for efficient liver specific gene transfer
title_full	Nano-vectors for efficient liver specific gene transfer
title_fullStr	Nano-vectors for efficient liver specific gene transfer
title_full_unstemmed	Nano-vectors for efficient liver specific gene transfer
title_sort	nano-vectors for efficient liver specific gene transfer
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/c62af6ace5944ce9bda7a1b76f852676
work_keys_str_mv	AT atulpathak nanovectorsforefficientliverspecificgenetransfer AT sureshpvyas nanovectorsforefficientliverspecificgenetransfer AT kailashcgupta nanovectorsforefficientliverspecificgenetransfer
_version_	1718403523121512448

Nano-vectors for efficient liver specific gene transfer

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