A twin study of early-childhood asthma in Puerto Ricans.

<h4>Background</h4>The relative contributions of genetics and environment to asthma in Hispanics or to asthma in children younger than 3 years are not well understood.<h4>Objective</h4>To examine the relative contributions of genetics and environment to early-childhood asthma...

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Autores principales:	Supinda Bunyavanich, Judy L Silberg, Jessica Lasky-Su, Nathan A Gillespie, Nancy E Lange, Glorisa Canino, Juan C Celedón
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c62d4e45b77f470f9fe294542018f90f
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spelling	oai:doaj.org-article:c62d4e45b77f470f9fe294542018f90f2021-11-18T07:38:39ZA twin study of early-childhood asthma in Puerto Ricans.1932-620310.1371/journal.pone.0068473https://doaj.org/article/c62d4e45b77f470f9fe294542018f90f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23844206/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The relative contributions of genetics and environment to asthma in Hispanics or to asthma in children younger than 3 years are not well understood.<h4>Objective</h4>To examine the relative contributions of genetics and environment to early-childhood asthma by performing a longitudinal twin study of asthma in Puerto Rican children ≤ 3 years old.<h4>Methods</h4>678 twin infants from the Puerto Rico Neo-Natal Twin Registry were assessed for asthma at age 1 year, with follow-up data obtained for 624 twins at age 3 years. Zygosity was determined by DNA microsatellite profiling. Structural equation modeling was performed for three phenotypes at ages 1 and 3 years: physician-diagnosed asthma, asthma medication use in the past year, and ≥ 1 hospitalization for asthma in the past year. Models were additionally adjusted for early-life environmental tobacco smoke exposure, sex, and age.<h4>Results</h4>The prevalences of physician-diagnosed asthma, asthma medication use, and hospitalization for asthma were 11.6%, 10.8%, 4.9% at age 1 year, and 34.1%, 40.1%, and 8.5% at 3 years, respectively. Shared environmental effects contributed to the majority of variance in susceptibility to physician-diagnosed asthma and asthma medication use in the first year of life (84%-86%), while genetic effects drove variance in all phenotypes (45%-65%) at age 3 years. Early-life environmental tobacco smoke, sex, and age contributed to variance in susceptibility.<h4>Conclusion</h4>Our longitudinal study in Puerto Rican twins demonstrates a changing contribution of shared environmental effects to liability for physician-diagnosed asthma and asthma medication use between ages 1 and 3 years. Early-life environmental tobacco smoke reduction could markedly reduce asthma morbidity in young Puerto Rican children.Supinda BunyavanichJudy L SilbergJessica Lasky-SuNathan A GillespieNancy E LangeGlorisa CaninoJuan C CeledónPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68473 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Supinda Bunyavanich Judy L Silberg Jessica Lasky-Su Nathan A Gillespie Nancy E Lange Glorisa Canino Juan C Celedón A twin study of early-childhood asthma in Puerto Ricans.
description	<h4>Background</h4>The relative contributions of genetics and environment to asthma in Hispanics or to asthma in children younger than 3 years are not well understood.<h4>Objective</h4>To examine the relative contributions of genetics and environment to early-childhood asthma by performing a longitudinal twin study of asthma in Puerto Rican children ≤ 3 years old.<h4>Methods</h4>678 twin infants from the Puerto Rico Neo-Natal Twin Registry were assessed for asthma at age 1 year, with follow-up data obtained for 624 twins at age 3 years. Zygosity was determined by DNA microsatellite profiling. Structural equation modeling was performed for three phenotypes at ages 1 and 3 years: physician-diagnosed asthma, asthma medication use in the past year, and ≥ 1 hospitalization for asthma in the past year. Models were additionally adjusted for early-life environmental tobacco smoke exposure, sex, and age.<h4>Results</h4>The prevalences of physician-diagnosed asthma, asthma medication use, and hospitalization for asthma were 11.6%, 10.8%, 4.9% at age 1 year, and 34.1%, 40.1%, and 8.5% at 3 years, respectively. Shared environmental effects contributed to the majority of variance in susceptibility to physician-diagnosed asthma and asthma medication use in the first year of life (84%-86%), while genetic effects drove variance in all phenotypes (45%-65%) at age 3 years. Early-life environmental tobacco smoke, sex, and age contributed to variance in susceptibility.<h4>Conclusion</h4>Our longitudinal study in Puerto Rican twins demonstrates a changing contribution of shared environmental effects to liability for physician-diagnosed asthma and asthma medication use between ages 1 and 3 years. Early-life environmental tobacco smoke reduction could markedly reduce asthma morbidity in young Puerto Rican children.
format	article
author	Supinda Bunyavanich Judy L Silberg Jessica Lasky-Su Nathan A Gillespie Nancy E Lange Glorisa Canino Juan C Celedón
author_facet	Supinda Bunyavanich Judy L Silberg Jessica Lasky-Su Nathan A Gillespie Nancy E Lange Glorisa Canino Juan C Celedón
author_sort	Supinda Bunyavanich
title	A twin study of early-childhood asthma in Puerto Ricans.
title_short	A twin study of early-childhood asthma in Puerto Ricans.
title_full	A twin study of early-childhood asthma in Puerto Ricans.
title_fullStr	A twin study of early-childhood asthma in Puerto Ricans.
title_full_unstemmed	A twin study of early-childhood asthma in Puerto Ricans.
title_sort	twin study of early-childhood asthma in puerto ricans.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/c62d4e45b77f470f9fe294542018f90f
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A twin study of early-childhood asthma in Puerto Ricans.

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