Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood

FGF21 exerts beneficial metabolic effects on multiple tissues. Here the authors show that the Fgf21 gene is demethylated during the postnatal suckling period, creating an epigenetic memory that determines the responsiveness of the Fgf21 gene to inducers such as PPARα activators or fasting in adultho...

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Autores principales:	Xunmei Yuan, Kazutaka Tsujimoto, Koshi Hashimoto, Kenichi Kawahori, Nozomi Hanzawa, Miho Hamaguchi, Takami Seki, Makiko Nawa, Tatsuya Ehara, Yohei Kitamura, Izuho Hatada, Morichika Konishi, Nobuyuki Itoh, Yoshimi Nakagawa, Hitoshi Shimano, Takako Takai-Igarashi, Yasutomi Kamei, Yoshihiro Ogawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c62f55c79e3144f582a03839a050d571
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spelling	oai:doaj.org-article:c62f55c79e3144f582a03839a050d5712021-12-02T16:56:39ZEpigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood10.1038/s41467-018-03038-w2041-1723https://doaj.org/article/c62f55c79e3144f582a03839a050d5712018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03038-whttps://doaj.org/toc/2041-1723FGF21 exerts beneficial metabolic effects on multiple tissues. Here the authors show that the Fgf21 gene is demethylated during the postnatal suckling period, creating an epigenetic memory that determines the responsiveness of the Fgf21 gene to inducers such as PPARα activators or fasting in adulthood.Xunmei YuanKazutaka TsujimotoKoshi HashimotoKenichi KawahoriNozomi HanzawaMiho HamaguchiTakami SekiMakiko NawaTatsuya EharaYohei KitamuraIzuho HatadaMorichika KonishiNobuyuki ItohYoshimi NakagawaHitoshi ShimanoTakako Takai-IgarashiYasutomi KameiYoshihiro OgawaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xunmei Yuan Kazutaka Tsujimoto Koshi Hashimoto Kenichi Kawahori Nozomi Hanzawa Miho Hamaguchi Takami Seki Makiko Nawa Tatsuya Ehara Yohei Kitamura Izuho Hatada Morichika Konishi Nobuyuki Itoh Yoshimi Nakagawa Hitoshi Shimano Takako Takai-Igarashi Yasutomi Kamei Yoshihiro Ogawa Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood
description	FGF21 exerts beneficial metabolic effects on multiple tissues. Here the authors show that the Fgf21 gene is demethylated during the postnatal suckling period, creating an epigenetic memory that determines the responsiveness of the Fgf21 gene to inducers such as PPARα activators or fasting in adulthood.
format	article
author	Xunmei Yuan Kazutaka Tsujimoto Koshi Hashimoto Kenichi Kawahori Nozomi Hanzawa Miho Hamaguchi Takami Seki Makiko Nawa Tatsuya Ehara Yohei Kitamura Izuho Hatada Morichika Konishi Nobuyuki Itoh Yoshimi Nakagawa Hitoshi Shimano Takako Takai-Igarashi Yasutomi Kamei Yoshihiro Ogawa
author_facet	Xunmei Yuan Kazutaka Tsujimoto Koshi Hashimoto Kenichi Kawahori Nozomi Hanzawa Miho Hamaguchi Takami Seki Makiko Nawa Tatsuya Ehara Yohei Kitamura Izuho Hatada Morichika Konishi Nobuyuki Itoh Yoshimi Nakagawa Hitoshi Shimano Takako Takai-Igarashi Yasutomi Kamei Yoshihiro Ogawa
author_sort	Xunmei Yuan
title	Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood
title_short	Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood
title_full	Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood
title_fullStr	Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood
title_full_unstemmed	Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood
title_sort	epigenetic modulation of fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c62f55c79e3144f582a03839a050d571
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Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood

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