Psychological Stress Deteriorates Skin Barrier Function by Activating 11β-Hydroxysteroid Dehydrogenase 1 and the HPA Axis

Abstract Psychological stress (PS) increases endogenous glucocorticoids (GC) by activating the hypothalamic-pituitary-adrenal axis. The negative effects of GC on skin barrier function under PS have been well-established. However, endogenous GC can also be active when cortisone (inactive form) is con...

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Autores principales:	Sung Jay Choe, Donghye Kim, Eun Jung Kim, Joung-Sook Ahn, Eun-Jeong Choi, Eui Dong Son, Tae Ryong Lee, Eung Ho Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c63014c69806416591aa3da08f51350b
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spelling	oai:doaj.org-article:c63014c69806416591aa3da08f51350b2021-12-02T15:08:13ZPsychological Stress Deteriorates Skin Barrier Function by Activating 11β-Hydroxysteroid Dehydrogenase 1 and the HPA Axis10.1038/s41598-018-24653-z2045-2322https://doaj.org/article/c63014c69806416591aa3da08f51350b2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24653-zhttps://doaj.org/toc/2045-2322Abstract Psychological stress (PS) increases endogenous glucocorticoids (GC) by activating the hypothalamic-pituitary-adrenal axis. The negative effects of GC on skin barrier function under PS have been well-established. However, endogenous GC can also be active when cortisone (inactive form) is converted to cortisol (active form) by 11β-hydroxysteroid dehydrogenase type I (11ß-HSD1) in the peripheral tissue. Here, we evaluated the changes in 11ß-HSD1 and barrier function under PS. Elevated 11ß-HSD1 in oral mucosa correlated with increased cortisol in the stratum corneum and deteriorated barrier function. Expression of 11ß-HSD1 in the oral mucosa correlated with that in the epidermal keratinocytes. We further investigated whether barrier function improved when PS was relieved using a selective serotonin reuptake inhibitor (SSRI) in patients with anxiety. Decreased 11ß-HSD1 and improved barrier function were observed after SSRI treatment. The collective findings suggest that elevated 11ß-HSD1 under PS increases the level of cutaneous GC and eventually impairs barrier function. PS-alleviating drugs, such as SSRI, may help to treat PS-aggravated skin diseases.Sung Jay ChoeDonghye KimEun Jung KimJoung-Sook AhnEun-Jeong ChoiEui Dong SonTae Ryong LeeEung Ho ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sung Jay Choe Donghye Kim Eun Jung Kim Joung-Sook Ahn Eun-Jeong Choi Eui Dong Son Tae Ryong Lee Eung Ho Choi Psychological Stress Deteriorates Skin Barrier Function by Activating 11β-Hydroxysteroid Dehydrogenase 1 and the HPA Axis
description	Abstract Psychological stress (PS) increases endogenous glucocorticoids (GC) by activating the hypothalamic-pituitary-adrenal axis. The negative effects of GC on skin barrier function under PS have been well-established. However, endogenous GC can also be active when cortisone (inactive form) is converted to cortisol (active form) by 11β-hydroxysteroid dehydrogenase type I (11ß-HSD1) in the peripheral tissue. Here, we evaluated the changes in 11ß-HSD1 and barrier function under PS. Elevated 11ß-HSD1 in oral mucosa correlated with increased cortisol in the stratum corneum and deteriorated barrier function. Expression of 11ß-HSD1 in the oral mucosa correlated with that in the epidermal keratinocytes. We further investigated whether barrier function improved when PS was relieved using a selective serotonin reuptake inhibitor (SSRI) in patients with anxiety. Decreased 11ß-HSD1 and improved barrier function were observed after SSRI treatment. The collective findings suggest that elevated 11ß-HSD1 under PS increases the level of cutaneous GC and eventually impairs barrier function. PS-alleviating drugs, such as SSRI, may help to treat PS-aggravated skin diseases.
format	article
author	Sung Jay Choe Donghye Kim Eun Jung Kim Joung-Sook Ahn Eun-Jeong Choi Eui Dong Son Tae Ryong Lee Eung Ho Choi
author_facet	Sung Jay Choe Donghye Kim Eun Jung Kim Joung-Sook Ahn Eun-Jeong Choi Eui Dong Son Tae Ryong Lee Eung Ho Choi
author_sort	Sung Jay Choe
title	Psychological Stress Deteriorates Skin Barrier Function by Activating 11β-Hydroxysteroid Dehydrogenase 1 and the HPA Axis
title_short	Psychological Stress Deteriorates Skin Barrier Function by Activating 11β-Hydroxysteroid Dehydrogenase 1 and the HPA Axis
title_full	Psychological Stress Deteriorates Skin Barrier Function by Activating 11β-Hydroxysteroid Dehydrogenase 1 and the HPA Axis
title_fullStr	Psychological Stress Deteriorates Skin Barrier Function by Activating 11β-Hydroxysteroid Dehydrogenase 1 and the HPA Axis
title_full_unstemmed	Psychological Stress Deteriorates Skin Barrier Function by Activating 11β-Hydroxysteroid Dehydrogenase 1 and the HPA Axis
title_sort	psychological stress deteriorates skin barrier function by activating 11β-hydroxysteroid dehydrogenase 1 and the hpa axis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c63014c69806416591aa3da08f51350b
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Psychological Stress Deteriorates Skin Barrier Function by Activating 11β-Hydroxysteroid Dehydrogenase 1 and the HPA Axis

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