Heterogeneity of odorant identification impairment in patients with Alzheimer’s Disease

Abstract Alzheimer’s disease (AD) patients exhibit olfactory dysfunction. However, the olfactory declineti precise nature is not fully understood. One hundred patients (60 AD, 28 amnestic mild cognitive impairment (aMCI), 12 Normal) were enrolled. All participants underwent olfactory function testin...

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Autores principales:	Yumi Umeda-Kameyama, Shinya Ishii, Masashi Kameyama, Kenji Kondo, Atsushi Ochi, Tatsuya Yamasoba, Sumito Ogawa, Masahiro Akishita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c6325ffcd88c4ff781d9c360d78998e5
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spelling	oai:doaj.org-article:c6325ffcd88c4ff781d9c360d78998e52021-12-02T11:53:10ZHeterogeneity of odorant identification impairment in patients with Alzheimer’s Disease10.1038/s41598-017-05201-72045-2322https://doaj.org/article/c6325ffcd88c4ff781d9c360d78998e52017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05201-7https://doaj.org/toc/2045-2322Abstract Alzheimer’s disease (AD) patients exhibit olfactory dysfunction. However, the olfactory declineti precise nature is not fully understood. One hundred patients (60 AD, 28 amnestic mild cognitive impairment (aMCI), 12 Normal) were enrolled. All participants underwent olfactory function testing using an odour stick identification test for Japanese (OSIT-J). OSIT-J scores were significantly correlated with recall. We classified OSIT-J odorants into three groups: Category I, odorants that were difficult for normal aged subjects to identify; Category II, odorants that became harder to accurately identify with cognitive decline; and Category III, odorants that even AD patients could identify. We defined a “cognitive subset” consisting of six Category II OSIT-J odorants (perfume, rose, Japanese cypress, curry, India ink and gas leak odour). The ability to identify “cognitive subset” odours was significantly better indicator of cognitive status than the ability to identify “non-cognitive subset”, which consisted of the six remaining items. The ability to identify the gas leak odorant was decreased early in the aMCI stage, suggesting a need to reconsider the odours used to signal gas leaks. The “cognitive subset” would provide a more convenient and effective biomarker for diagnosing dementia in clinical settings.Yumi Umeda-KameyamaShinya IshiiMasashi KameyamaKenji KondoAtsushi OchiTatsuya YamasobaSumito OgawaMasahiro AkishitaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yumi Umeda-Kameyama Shinya Ishii Masashi Kameyama Kenji Kondo Atsushi Ochi Tatsuya Yamasoba Sumito Ogawa Masahiro Akishita Heterogeneity of odorant identification impairment in patients with Alzheimer’s Disease
description	Abstract Alzheimer’s disease (AD) patients exhibit olfactory dysfunction. However, the olfactory declineti precise nature is not fully understood. One hundred patients (60 AD, 28 amnestic mild cognitive impairment (aMCI), 12 Normal) were enrolled. All participants underwent olfactory function testing using an odour stick identification test for Japanese (OSIT-J). OSIT-J scores were significantly correlated with recall. We classified OSIT-J odorants into three groups: Category I, odorants that were difficult for normal aged subjects to identify; Category II, odorants that became harder to accurately identify with cognitive decline; and Category III, odorants that even AD patients could identify. We defined a “cognitive subset” consisting of six Category II OSIT-J odorants (perfume, rose, Japanese cypress, curry, India ink and gas leak odour). The ability to identify “cognitive subset” odours was significantly better indicator of cognitive status than the ability to identify “non-cognitive subset”, which consisted of the six remaining items. The ability to identify the gas leak odorant was decreased early in the aMCI stage, suggesting a need to reconsider the odours used to signal gas leaks. The “cognitive subset” would provide a more convenient and effective biomarker for diagnosing dementia in clinical settings.
format	article
author	Yumi Umeda-Kameyama Shinya Ishii Masashi Kameyama Kenji Kondo Atsushi Ochi Tatsuya Yamasoba Sumito Ogawa Masahiro Akishita
author_facet	Yumi Umeda-Kameyama Shinya Ishii Masashi Kameyama Kenji Kondo Atsushi Ochi Tatsuya Yamasoba Sumito Ogawa Masahiro Akishita
author_sort	Yumi Umeda-Kameyama
title	Heterogeneity of odorant identification impairment in patients with Alzheimer’s Disease
title_short	Heterogeneity of odorant identification impairment in patients with Alzheimer’s Disease
title_full	Heterogeneity of odorant identification impairment in patients with Alzheimer’s Disease
title_fullStr	Heterogeneity of odorant identification impairment in patients with Alzheimer’s Disease
title_full_unstemmed	Heterogeneity of odorant identification impairment in patients with Alzheimer’s Disease
title_sort	heterogeneity of odorant identification impairment in patients with alzheimer’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c6325ffcd88c4ff781d9c360d78998e5
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Heterogeneity of odorant identification impairment in patients with Alzheimer’s Disease

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