Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase

Plasmodium falciparum IMP-specific 5′-nucleotidase 1 (PfISN1) is of interest as a potential malaria drug target. Here, the authors report that IMP is a substrate, and ATP an allosteric activator, of PfISN1 and present PfISN1 crystal structures in the ligand-free state and bound to either IMP or ATP....

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Autores principales:	Loïc Carrique, Lionel Ballut, Arpit Shukla, Neelakshi Varma, Resmi Ravi, Sébastien Violot, Bharath Srinivasan, Umesh Tippagondanahalli Ganeshappa, Sonia Kulkarni, Hemalatha Balaram, Nushin Aghajari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c632ca110e894c0abfd98854ea286089
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spelling	oai:doaj.org-article:c632ca110e894c0abfd98854ea2860892021-12-02T17:45:00ZStructure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase10.1038/s41467-020-17013-x2041-1723https://doaj.org/article/c632ca110e894c0abfd98854ea2860892020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17013-xhttps://doaj.org/toc/2041-1723Plasmodium falciparum IMP-specific 5′-nucleotidase 1 (PfISN1) is of interest as a potential malaria drug target. Here, the authors report that IMP is a substrate, and ATP an allosteric activator, of PfISN1 and present PfISN1 crystal structures in the ligand-free state and bound to either IMP or ATP.Loïc CarriqueLionel BallutArpit ShuklaNeelakshi VarmaResmi RaviSébastien ViolotBharath SrinivasanUmesh Tippagondanahalli GaneshappaSonia KulkarniHemalatha BalaramNushin AghajariNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Loïc Carrique Lionel Ballut Arpit Shukla Neelakshi Varma Resmi Ravi Sébastien Violot Bharath Srinivasan Umesh Tippagondanahalli Ganeshappa Sonia Kulkarni Hemalatha Balaram Nushin Aghajari Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase
description	Plasmodium falciparum IMP-specific 5′-nucleotidase 1 (PfISN1) is of interest as a potential malaria drug target. Here, the authors report that IMP is a substrate, and ATP an allosteric activator, of PfISN1 and present PfISN1 crystal structures in the ligand-free state and bound to either IMP or ATP.
format	article
author	Loïc Carrique Lionel Ballut Arpit Shukla Neelakshi Varma Resmi Ravi Sébastien Violot Bharath Srinivasan Umesh Tippagondanahalli Ganeshappa Sonia Kulkarni Hemalatha Balaram Nushin Aghajari
author_facet	Loïc Carrique Lionel Ballut Arpit Shukla Neelakshi Varma Resmi Ravi Sébastien Violot Bharath Srinivasan Umesh Tippagondanahalli Ganeshappa Sonia Kulkarni Hemalatha Balaram Nushin Aghajari
author_sort	Loïc Carrique
title	Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase
title_short	Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase
title_full	Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase
title_fullStr	Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase
title_full_unstemmed	Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase
title_sort	structure and catalytic regulation of plasmodium falciparum imp specific nucleotidase
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c632ca110e894c0abfd98854ea286089
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_version_	1718379612103245824

Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase

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