Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds

Cancer is one of the leading causes of death globally. Epidemiological studies have strongly linked a diet high in fruits to a lower incidence of cancer. Furthermore, extensive research shows that secondary plant metabolites known as phytochemicals, which are commonly found in fruits, have onco-prev...

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Autores principales:	Linda Nezbedova, Tony McGhie, Mark Christensen, Julian Heyes, Noha Ahmed Nasef, Sunali Mehta
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	fruit apple phytochemicals cancer chemoprevention antioxidants Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/c6361153d4a545eea4fb2e157105abd9
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id	oai:doaj.org-article:c6361153d4a545eea4fb2e157105abd9
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spelling	oai:doaj.org-article:c6361153d4a545eea4fb2e157105abd92021-11-25T18:36:12ZOnco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds10.3390/nu131140252072-6643https://doaj.org/article/c6361153d4a545eea4fb2e157105abd92021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4025https://doaj.org/toc/2072-6643Cancer is one of the leading causes of death globally. Epidemiological studies have strongly linked a diet high in fruits to a lower incidence of cancer. Furthermore, extensive research shows that secondary plant metabolites known as phytochemicals, which are commonly found in fruits, have onco-preventive and chemo-protective effects. Apple is a commonly consumed fruit worldwide that is available all year round and is a rich source of phytochemicals. In this review, we summarize the association of apple consumption with cancer incidence based on findings from epidemiological and cohort studies. We further provide a comprehensive review of the main phytochemical patterns observed in apples and their bioavailability after consumption. Finally, we report on the latest findings from in vitro and in vivo studies highlighting some of the key molecular mechanisms targeted by apple phytochemicals in relation to inhibiting multiple ‘hallmarks of cancer’ that are important in the progression of cancer.Linda NezbedovaTony McGhieMark ChristensenJulian HeyesNoha Ahmed NasefSunali MehtaMDPI AGarticlefruitapplephytochemicalscancerchemopreventionantioxidantsNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4025, p 4025 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fruit apple phytochemicals cancer chemoprevention antioxidants Nutrition. Foods and food supply TX341-641
spellingShingle	fruit apple phytochemicals cancer chemoprevention antioxidants Nutrition. Foods and food supply TX341-641 Linda Nezbedova Tony McGhie Mark Christensen Julian Heyes Noha Ahmed Nasef Sunali Mehta Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds
description	Cancer is one of the leading causes of death globally. Epidemiological studies have strongly linked a diet high in fruits to a lower incidence of cancer. Furthermore, extensive research shows that secondary plant metabolites known as phytochemicals, which are commonly found in fruits, have onco-preventive and chemo-protective effects. Apple is a commonly consumed fruit worldwide that is available all year round and is a rich source of phytochemicals. In this review, we summarize the association of apple consumption with cancer incidence based on findings from epidemiological and cohort studies. We further provide a comprehensive review of the main phytochemical patterns observed in apples and their bioavailability after consumption. Finally, we report on the latest findings from in vitro and in vivo studies highlighting some of the key molecular mechanisms targeted by apple phytochemicals in relation to inhibiting multiple ‘hallmarks of cancer’ that are important in the progression of cancer.
format	article
author	Linda Nezbedova Tony McGhie Mark Christensen Julian Heyes Noha Ahmed Nasef Sunali Mehta
author_facet	Linda Nezbedova Tony McGhie Mark Christensen Julian Heyes Noha Ahmed Nasef Sunali Mehta
author_sort	Linda Nezbedova
title	Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds
title_short	Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds
title_full	Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds
title_fullStr	Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds
title_full_unstemmed	Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds
title_sort	onco-preventive and chemo-protective effects of apple bioactive compounds
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c6361153d4a545eea4fb2e157105abd9
work_keys_str_mv	AT lindanezbedova oncopreventiveandchemoprotectiveeffectsofapplebioactivecompounds AT tonymcghie oncopreventiveandchemoprotectiveeffectsofapplebioactivecompounds AT markchristensen oncopreventiveandchemoprotectiveeffectsofapplebioactivecompounds AT julianheyes oncopreventiveandchemoprotectiveeffectsofapplebioactivecompounds AT nohaahmednasef oncopreventiveandchemoprotectiveeffectsofapplebioactivecompounds AT sunalimehta oncopreventiveandchemoprotectiveeffectsofapplebioactivecompounds
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Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds

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