Reconciling Ecological and Engineering Design Principles for Building Microbiomes

ABSTRACT Simplified microbial communities, or “benchtop microbiomes,” enable us to manage the profound complexity of microbial ecosystems. Widespread activities aiming to design and control communities result in novel resources for testing ecological theories and also for realizing new biotechnologi...

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Autor principal:	Hans C. Bernstein
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	community coalescence ecological processes environmental filtering functional trait space microbial community microbial ecosystem Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c63669bf3f014af78ecd56d30e2a3355
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spelling	oai:doaj.org-article:c63669bf3f014af78ecd56d30e2a33552021-12-02T19:46:18ZReconciling Ecological and Engineering Design Principles for Building Microbiomes10.1128/mSystems.00106-192379-5077https://doaj.org/article/c63669bf3f014af78ecd56d30e2a33552019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00106-19https://doaj.org/toc/2379-5077ABSTRACT Simplified microbial communities, or “benchtop microbiomes,” enable us to manage the profound complexity of microbial ecosystems. Widespread activities aiming to design and control communities result in novel resources for testing ecological theories and also for realizing new biotechnologies. There is much to be gained by reconciling engineering design principles with ecological processes that shape microbiomes in nature. In this short Perspective, I will address how natural processes such as environmental filtering, the establishment of priority effects, and community “blending” (coalescence) can be harnessed for engineering microbiomes from complex starting materials. I will also discuss how future microbiome architects may draw inspiration from modern practices in synthetic biology. This topic is based on an important overarching research goal, which is to understand how natural forces shape microbial communities and interspecies interactions such that new engineering design principles can be extracted to promote human health or energy and environmental sustainability.Hans C. BernsteinAmerican Society for Microbiologyarticlecommunity coalescenceecological processesenvironmental filteringfunctional trait spacemicrobial communitymicrobial ecosystemMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	community coalescence ecological processes environmental filtering functional trait space microbial community microbial ecosystem Microbiology QR1-502
spellingShingle	community coalescence ecological processes environmental filtering functional trait space microbial community microbial ecosystem Microbiology QR1-502 Hans C. Bernstein Reconciling Ecological and Engineering Design Principles for Building Microbiomes
description	ABSTRACT Simplified microbial communities, or “benchtop microbiomes,” enable us to manage the profound complexity of microbial ecosystems. Widespread activities aiming to design and control communities result in novel resources for testing ecological theories and also for realizing new biotechnologies. There is much to be gained by reconciling engineering design principles with ecological processes that shape microbiomes in nature. In this short Perspective, I will address how natural processes such as environmental filtering, the establishment of priority effects, and community “blending” (coalescence) can be harnessed for engineering microbiomes from complex starting materials. I will also discuss how future microbiome architects may draw inspiration from modern practices in synthetic biology. This topic is based on an important overarching research goal, which is to understand how natural forces shape microbial communities and interspecies interactions such that new engineering design principles can be extracted to promote human health or energy and environmental sustainability.
format	article
author	Hans C. Bernstein
author_facet	Hans C. Bernstein
author_sort	Hans C. Bernstein
title	Reconciling Ecological and Engineering Design Principles for Building Microbiomes
title_short	Reconciling Ecological and Engineering Design Principles for Building Microbiomes
title_full	Reconciling Ecological and Engineering Design Principles for Building Microbiomes
title_fullStr	Reconciling Ecological and Engineering Design Principles for Building Microbiomes
title_full_unstemmed	Reconciling Ecological and Engineering Design Principles for Building Microbiomes
title_sort	reconciling ecological and engineering design principles for building microbiomes
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/c63669bf3f014af78ecd56d30e2a3355
work_keys_str_mv	AT hanscbernstein reconcilingecologicalandengineeringdesignprinciplesforbuildingmicrobiomes
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Reconciling Ecological and Engineering Design Principles for Building Microbiomes

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