Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10

Salmonella secretes the effector protein SopD into the host cell cytoplasm, leading to scission of the plasma membrane through unclear mechanisms. Here, Boddy et al. show that SopD binds to and inhibits the small GTPase Rab10, thus promoting removal of Rab10 and recruitment of dynamin-2 to drive pla...

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Autores principales:	Kirsten C. Boddy, Hongxian Zhu, Vanessa M. D’Costa, Caishuang Xu, Ksenia Beyrakhova, Miroslaw Cygler, Sergio Grinstein, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Brian Raught, John H. Brumell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c637d11be435406898ecf3fc34ead099
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spelling	oai:doaj.org-article:c637d11be435406898ecf3fc34ead0992021-12-02T17:06:34ZSalmonella effector SopD promotes plasma membrane scission by inhibiting Rab1010.1038/s41467-021-24983-z2041-1723https://doaj.org/article/c637d11be435406898ecf3fc34ead0992021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24983-zhttps://doaj.org/toc/2041-1723Salmonella secretes the effector protein SopD into the host cell cytoplasm, leading to scission of the plasma membrane through unclear mechanisms. Here, Boddy et al. show that SopD binds to and inhibits the small GTPase Rab10, thus promoting removal of Rab10 and recruitment of dynamin-2 to drive plasma membrane scission.Kirsten C. BoddyHongxian ZhuVanessa M. D’CostaCaishuang XuKsenia BeyrakhovaMiroslaw CyglerSergio GrinsteinEtienne CoyaudEstelle M. N. LaurentJonathan St-GermainBrian RaughtJohn H. BrumellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kirsten C. Boddy Hongxian Zhu Vanessa M. D’Costa Caishuang Xu Ksenia Beyrakhova Miroslaw Cygler Sergio Grinstein Etienne Coyaud Estelle M. N. Laurent Jonathan St-Germain Brian Raught John H. Brumell Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10
description	Salmonella secretes the effector protein SopD into the host cell cytoplasm, leading to scission of the plasma membrane through unclear mechanisms. Here, Boddy et al. show that SopD binds to and inhibits the small GTPase Rab10, thus promoting removal of Rab10 and recruitment of dynamin-2 to drive plasma membrane scission.
format	article
author	Kirsten C. Boddy Hongxian Zhu Vanessa M. D’Costa Caishuang Xu Ksenia Beyrakhova Miroslaw Cygler Sergio Grinstein Etienne Coyaud Estelle M. N. Laurent Jonathan St-Germain Brian Raught John H. Brumell
author_facet	Kirsten C. Boddy Hongxian Zhu Vanessa M. D’Costa Caishuang Xu Ksenia Beyrakhova Miroslaw Cygler Sergio Grinstein Etienne Coyaud Estelle M. N. Laurent Jonathan St-Germain Brian Raught John H. Brumell
author_sort	Kirsten C. Boddy
title	Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10
title_short	Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10
title_full	Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10
title_fullStr	Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10
title_full_unstemmed	Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10
title_sort	salmonella effector sopd promotes plasma membrane scission by inhibiting rab10
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c637d11be435406898ecf3fc34ead099
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Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10

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