Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10

Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10

Salmonella secretes the effector protein SopD into the host cell cytoplasm, leading to scission of the plasma membrane through unclear mechanisms. Here, Boddy et al. show that SopD binds to and inhibits the small GTPase Rab10, thus promoting removal of Rab10 and recruitment of dynamin-2 to drive pla...

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Autores principales: Kirsten C. Boddy, Hongxian Zhu, Vanessa M. D’Costa, Caishuang Xu, Ksenia Beyrakhova, Miroslaw Cygler, Sergio Grinstein, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Brian Raught, John H. Brumell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/c637d11be435406898ecf3fc34ead099
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