Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination

Current treatments of multiple sclerosis are aimed at immunosuppression. Here the authors show that kappa opioid receptor is important for oligodendrocyte differentiation and myelination and the receptor agonists are protective in a mouse model of multiple sclerosis.

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Autores principales:	Changsheng Du, Yanhui Duan, Wei Wei, Yingying Cai, Hui Chai, Jie Lv, Xiling Du, Jian Zhu, Xin Xie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c63bdc847ad944e9864d75fabc4e718b
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spelling	oai:doaj.org-article:c63bdc847ad944e9864d75fabc4e718b2021-12-02T14:38:35ZKappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination10.1038/ncomms111202041-1723https://doaj.org/article/c63bdc847ad944e9864d75fabc4e718b2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11120https://doaj.org/toc/2041-1723Current treatments of multiple sclerosis are aimed at immunosuppression. Here the authors show that kappa opioid receptor is important for oligodendrocyte differentiation and myelination and the receptor agonists are protective in a mouse model of multiple sclerosis.Changsheng DuYanhui DuanWei WeiYingying CaiHui ChaiJie LvXiling DuJian ZhuXin XieNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Changsheng Du Yanhui Duan Wei Wei Yingying Cai Hui Chai Jie Lv Xiling Du Jian Zhu Xin Xie Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination
description	Current treatments of multiple sclerosis are aimed at immunosuppression. Here the authors show that kappa opioid receptor is important for oligodendrocyte differentiation and myelination and the receptor agonists are protective in a mouse model of multiple sclerosis.
format	article
author	Changsheng Du Yanhui Duan Wei Wei Yingying Cai Hui Chai Jie Lv Xiling Du Jian Zhu Xin Xie
author_facet	Changsheng Du Yanhui Duan Wei Wei Yingying Cai Hui Chai Jie Lv Xiling Du Jian Zhu Xin Xie
author_sort	Changsheng Du
title	Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination
title_short	Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination
title_full	Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination
title_fullStr	Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination
title_full_unstemmed	Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination
title_sort	kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c63bdc847ad944e9864d75fabc4e718b
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Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination

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