Visual response of ventrolateral prefrontal neurons and their behavior-related modulation

Abstract The ventral part of lateral prefrontal cortex (VLPF) of the monkey receives strong visual input, mainly from inferotemporal cortex. It has been shown that VLPF neurons can show visual responses during paradigms requiring to associate arbitrary visual cues to behavioral reactions. Further st...

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Autores principales:	Stefano Rozzi, Marco Bimbi, Alfonso Gravante, Luciano Simone, Leonardo Fogassi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c63e524789834629ac06a6f6f0e24c7a
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spelling	oai:doaj.org-article:c63e524789834629ac06a6f6f0e24c7a2021-12-02T15:55:03ZVisual response of ventrolateral prefrontal neurons and their behavior-related modulation10.1038/s41598-021-89500-02045-2322https://doaj.org/article/c63e524789834629ac06a6f6f0e24c7a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89500-0https://doaj.org/toc/2045-2322Abstract The ventral part of lateral prefrontal cortex (VLPF) of the monkey receives strong visual input, mainly from inferotemporal cortex. It has been shown that VLPF neurons can show visual responses during paradigms requiring to associate arbitrary visual cues to behavioral reactions. Further studies showed that there are also VLPF neurons responding to the presentation of specific visual stimuli, such as objects and faces. However, it is largely unknown whether VLPF neurons respond and differentiate between stimuli belonging to different categories, also in absence of a specific requirement to actively categorize or to exploit these stimuli for choosing a given behavior. The first aim of the present study is to evaluate and map the responses of neurons of a large sector of VLPF to a wide set of visual stimuli when monkeys simply observe them. Recent studies showed that visual responses to objects are also present in VLPF neurons coding action execution, when they are the target of the action. Thus, the second aim of the present study is to compare the visual responses of VLPF neurons when the same objects are simply observed or when they become the target of a grasping action. Our results indicate that: (1) part of VLPF visually responsive neurons respond specifically to one stimulus or to a small set of stimuli, but there is no indication of a “passive” categorical coding; (2) VLPF neuronal visual responses to objects are often modulated by the task conditions in which the object is observed, with the strongest response when the object is target of an action. These data indicate that VLPF performs an early passive description of several types of visual stimuli, that can then be used for organizing and planning behavior. This could explain the modulation of visual response both in associative learning and in natural behavior.Stefano RozziMarco BimbiAlfonso GravanteLuciano SimoneLeonardo FogassiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefano Rozzi Marco Bimbi Alfonso Gravante Luciano Simone Leonardo Fogassi Visual response of ventrolateral prefrontal neurons and their behavior-related modulation
description	Abstract The ventral part of lateral prefrontal cortex (VLPF) of the monkey receives strong visual input, mainly from inferotemporal cortex. It has been shown that VLPF neurons can show visual responses during paradigms requiring to associate arbitrary visual cues to behavioral reactions. Further studies showed that there are also VLPF neurons responding to the presentation of specific visual stimuli, such as objects and faces. However, it is largely unknown whether VLPF neurons respond and differentiate between stimuli belonging to different categories, also in absence of a specific requirement to actively categorize or to exploit these stimuli for choosing a given behavior. The first aim of the present study is to evaluate and map the responses of neurons of a large sector of VLPF to a wide set of visual stimuli when monkeys simply observe them. Recent studies showed that visual responses to objects are also present in VLPF neurons coding action execution, when they are the target of the action. Thus, the second aim of the present study is to compare the visual responses of VLPF neurons when the same objects are simply observed or when they become the target of a grasping action. Our results indicate that: (1) part of VLPF visually responsive neurons respond specifically to one stimulus or to a small set of stimuli, but there is no indication of a “passive” categorical coding; (2) VLPF neuronal visual responses to objects are often modulated by the task conditions in which the object is observed, with the strongest response when the object is target of an action. These data indicate that VLPF performs an early passive description of several types of visual stimuli, that can then be used for organizing and planning behavior. This could explain the modulation of visual response both in associative learning and in natural behavior.
format	article
author	Stefano Rozzi Marco Bimbi Alfonso Gravante Luciano Simone Leonardo Fogassi
author_facet	Stefano Rozzi Marco Bimbi Alfonso Gravante Luciano Simone Leonardo Fogassi
author_sort	Stefano Rozzi
title	Visual response of ventrolateral prefrontal neurons and their behavior-related modulation
title_short	Visual response of ventrolateral prefrontal neurons and their behavior-related modulation
title_full	Visual response of ventrolateral prefrontal neurons and their behavior-related modulation
title_fullStr	Visual response of ventrolateral prefrontal neurons and their behavior-related modulation
title_full_unstemmed	Visual response of ventrolateral prefrontal neurons and their behavior-related modulation
title_sort	visual response of ventrolateral prefrontal neurons and their behavior-related modulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c63e524789834629ac06a6f6f0e24c7a
work_keys_str_mv	AT stefanorozzi visualresponseofventrolateralprefrontalneuronsandtheirbehaviorrelatedmodulation AT marcobimbi visualresponseofventrolateralprefrontalneuronsandtheirbehaviorrelatedmodulation AT alfonsogravante visualresponseofventrolateralprefrontalneuronsandtheirbehaviorrelatedmodulation AT lucianosimone visualresponseofventrolateralprefrontalneuronsandtheirbehaviorrelatedmodulation AT leonardofogassi visualresponseofventrolateralprefrontalneuronsandtheirbehaviorrelatedmodulation
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Visual response of ventrolateral prefrontal neurons and their behavior-related modulation

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