Neuronal morphology alterations in autism and possible role of oxytocin

Current understanding of the neuroanatomical abnormalities in autism includes gross anatomical changes in several brain areas and microstructural alterations in neuronal cells as well. There are many controversies in the interpretation of the imaging data, evaluation of volume and size of particular...

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Autores principales:	Falougy Hisham El, Filova Barbora, Ostatnikova Daniela, Bacova Zuzana, Bakos Jan
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2019
Materias:	oxytocin autism brain anatomy structural neuronal changes Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/c64103291b504d018afbe77e9c4bbb03
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id	oai:doaj.org-article:c64103291b504d018afbe77e9c4bbb03
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spelling	oai:doaj.org-article:c64103291b504d018afbe77e9c4bbb032021-12-02T19:07:37ZNeuronal morphology alterations in autism and possible role of oxytocin1336-032910.2478/enr-2019-0006https://doaj.org/article/c64103291b504d018afbe77e9c4bbb032019-01-01T00:00:00Zhttps://doi.org/10.2478/enr-2019-0006https://doaj.org/toc/1336-0329Current understanding of the neuroanatomical abnormalities in autism includes gross anatomical changes in several brain areas and microstructural alterations in neuronal cells as well. There are many controversies in the interpretation of the imaging data, evaluation of volume and size of particular brain areas, and their functional translation into a broad autism phenotype. Critical questions of neuronal pathology in autism include the concept of the reversible plasticity of morphological changes, volume alterations of brain areas, and both short- and long-term consequences of adverse events present during the brain development. At the cellular level, remodeling of the actin cytoskeleton is considered as one of the critical factors associated with the autism spectrum disorders. Alterations in the composition of the neuronal cytoskeleton, in particular abnormalities in the polymerization of actin filaments and their associated proteins underlie the functional consequences in behavior resulting in symptoms and clinical correlates of autism spectrum disorder. In the present review, a special attention is devoted to the role of oxytocin in experimental models of neurodevelopmental disorders manifesting alterations in neuronal morphology.Falougy Hisham ElFilova BarboraOstatnikova DanielaBacova ZuzanaBakos JanSciendoarticleoxytocinautismbrain anatomystructural neuronal changesDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 53, Iss 1, Pp 46-54 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxytocin autism brain anatomy structural neuronal changes Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	oxytocin autism brain anatomy structural neuronal changes Diseases of the endocrine glands. Clinical endocrinology RC648-665 Falougy Hisham El Filova Barbora Ostatnikova Daniela Bacova Zuzana Bakos Jan Neuronal morphology alterations in autism and possible role of oxytocin
description	Current understanding of the neuroanatomical abnormalities in autism includes gross anatomical changes in several brain areas and microstructural alterations in neuronal cells as well. There are many controversies in the interpretation of the imaging data, evaluation of volume and size of particular brain areas, and their functional translation into a broad autism phenotype. Critical questions of neuronal pathology in autism include the concept of the reversible plasticity of morphological changes, volume alterations of brain areas, and both short- and long-term consequences of adverse events present during the brain development. At the cellular level, remodeling of the actin cytoskeleton is considered as one of the critical factors associated with the autism spectrum disorders. Alterations in the composition of the neuronal cytoskeleton, in particular abnormalities in the polymerization of actin filaments and their associated proteins underlie the functional consequences in behavior resulting in symptoms and clinical correlates of autism spectrum disorder. In the present review, a special attention is devoted to the role of oxytocin in experimental models of neurodevelopmental disorders manifesting alterations in neuronal morphology.
format	article
author	Falougy Hisham El Filova Barbora Ostatnikova Daniela Bacova Zuzana Bakos Jan
author_facet	Falougy Hisham El Filova Barbora Ostatnikova Daniela Bacova Zuzana Bakos Jan
author_sort	Falougy Hisham El
title	Neuronal morphology alterations in autism and possible role of oxytocin
title_short	Neuronal morphology alterations in autism and possible role of oxytocin
title_full	Neuronal morphology alterations in autism and possible role of oxytocin
title_fullStr	Neuronal morphology alterations in autism and possible role of oxytocin
title_full_unstemmed	Neuronal morphology alterations in autism and possible role of oxytocin
title_sort	neuronal morphology alterations in autism and possible role of oxytocin
publisher	Sciendo
publishDate	2019
url	https://doaj.org/article/c64103291b504d018afbe77e9c4bbb03
work_keys_str_mv	AT falougyhishamel neuronalmorphologyalterationsinautismandpossibleroleofoxytocin AT filovabarbora neuronalmorphologyalterationsinautismandpossibleroleofoxytocin AT ostatnikovadaniela neuronalmorphologyalterationsinautismandpossibleroleofoxytocin AT bacovazuzana neuronalmorphologyalterationsinautismandpossibleroleofoxytocin AT bakosjan neuronalmorphologyalterationsinautismandpossibleroleofoxytocin
_version_	1718377174863446016

Neuronal morphology alterations in autism and possible role of oxytocin

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