Examining early structural and functional brain alterations in postpartum depression through multimodal neuroimaging

Abstract Postpartum depression (PPD) affects approximately 1 in 10 women after childbirth. A thorough understanding of a preexisting vulnerability to PPD will likely aid the early detection and treatment of PPD. Using a within-sample association, the study examined whether the brain’s structural and...

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Autores principales:	Patricia Schnakenberg, Lisa Hahn, Susanne Stickel, Elmar Stickeler, Ute Habel, Simon B. Eickhoff, Natalia Chechko, Juergen Dukart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c649017727664b578cca166e84802df4
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spelling	oai:doaj.org-article:c649017727664b578cca166e84802df42021-12-02T16:10:36ZExamining early structural and functional brain alterations in postpartum depression through multimodal neuroimaging10.1038/s41598-021-92882-w2045-2322https://doaj.org/article/c649017727664b578cca166e84802df42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92882-whttps://doaj.org/toc/2045-2322Abstract Postpartum depression (PPD) affects approximately 1 in 10 women after childbirth. A thorough understanding of a preexisting vulnerability to PPD will likely aid the early detection and treatment of PPD. Using a within-sample association, the study examined whether the brain’s structural and functional alterations predict the onset of depression. 157 euthymic postpartum women were subjected to a multimodal MRI scan within the first 6 days of childbirth and were followed up for 12 weeks. Based on a clinical interview 12 weeks postpartum, participants were classified as mentally healthy or having either PPD or adjustment disorder (AD). Voxel-based morphometry and resting-state functional connectivity comparisons were performed between the three groups. 13.4% of women in our study developed PPD (n = 21) and 12.1% (n = 19) adjustment disorder (AD). The risk factors for PPD were a psychiatric history and the experience and severity of baby blues and the history of premenstrual syndrome. Despite the different risk profiles, no differences between the PPD, AD and control group were apparent based on structural and functional neuroimaging data immediately after childbirth. At 12 weeks postpartum, a significant association was observed between Integrated Local Correlation (LCor) and the Edinburgh Postnatal Depression Score (EPDS). Our findings do not support the notion that the brain’s structural and resting-state functional alterations, if present, can be used as an early biomarker of PPD or AD. However, effects may become apparent if continuous measures of symptom severity are chosen.Patricia SchnakenbergLisa HahnSusanne StickelElmar StickelerUte HabelSimon B. EickhoffNatalia ChechkoJuergen DukartNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Patricia Schnakenberg Lisa Hahn Susanne Stickel Elmar Stickeler Ute Habel Simon B. Eickhoff Natalia Chechko Juergen Dukart Examining early structural and functional brain alterations in postpartum depression through multimodal neuroimaging
description	Abstract Postpartum depression (PPD) affects approximately 1 in 10 women after childbirth. A thorough understanding of a preexisting vulnerability to PPD will likely aid the early detection and treatment of PPD. Using a within-sample association, the study examined whether the brain’s structural and functional alterations predict the onset of depression. 157 euthymic postpartum women were subjected to a multimodal MRI scan within the first 6 days of childbirth and were followed up for 12 weeks. Based on a clinical interview 12 weeks postpartum, participants were classified as mentally healthy or having either PPD or adjustment disorder (AD). Voxel-based morphometry and resting-state functional connectivity comparisons were performed between the three groups. 13.4% of women in our study developed PPD (n = 21) and 12.1% (n = 19) adjustment disorder (AD). The risk factors for PPD were a psychiatric history and the experience and severity of baby blues and the history of premenstrual syndrome. Despite the different risk profiles, no differences between the PPD, AD and control group were apparent based on structural and functional neuroimaging data immediately after childbirth. At 12 weeks postpartum, a significant association was observed between Integrated Local Correlation (LCor) and the Edinburgh Postnatal Depression Score (EPDS). Our findings do not support the notion that the brain’s structural and resting-state functional alterations, if present, can be used as an early biomarker of PPD or AD. However, effects may become apparent if continuous measures of symptom severity are chosen.
format	article
author	Patricia Schnakenberg Lisa Hahn Susanne Stickel Elmar Stickeler Ute Habel Simon B. Eickhoff Natalia Chechko Juergen Dukart
author_facet	Patricia Schnakenberg Lisa Hahn Susanne Stickel Elmar Stickeler Ute Habel Simon B. Eickhoff Natalia Chechko Juergen Dukart
author_sort	Patricia Schnakenberg
title	Examining early structural and functional brain alterations in postpartum depression through multimodal neuroimaging
title_short	Examining early structural and functional brain alterations in postpartum depression through multimodal neuroimaging
title_full	Examining early structural and functional brain alterations in postpartum depression through multimodal neuroimaging
title_fullStr	Examining early structural and functional brain alterations in postpartum depression through multimodal neuroimaging
title_full_unstemmed	Examining early structural and functional brain alterations in postpartum depression through multimodal neuroimaging
title_sort	examining early structural and functional brain alterations in postpartum depression through multimodal neuroimaging
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c649017727664b578cca166e84802df4
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Examining early structural and functional brain alterations in postpartum depression through multimodal neuroimaging

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