Swedish intrauterine growth reference ranges of biometric measurements of fetal head, abdomen and femur

Abstract Ultrasonic assessment of fetal growth is an important part of obstetric care to prevent adverse pregnancy outcome. However, lack of reliable reference ranges is a major barrier for accurate interpretation of the examinations. The aim of this study was to create updated Swedish national refe...

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Autores principales:	Linda Lindström, Mårten Ageheim, Ove Axelsson, Laith Hussain-Alkhateeb, Alkistis Skalkidou, Eva Bergman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c649cd1db0c64b17931a43f9932f6081
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spelling	oai:doaj.org-article:c649cd1db0c64b17931a43f9932f60812021-12-02T14:01:28ZSwedish intrauterine growth reference ranges of biometric measurements of fetal head, abdomen and femur10.1038/s41598-020-79797-82045-2322https://doaj.org/article/c649cd1db0c64b17931a43f9932f60812020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79797-8https://doaj.org/toc/2045-2322Abstract Ultrasonic assessment of fetal growth is an important part of obstetric care to prevent adverse pregnancy outcome. However, lack of reliable reference ranges is a major barrier for accurate interpretation of the examinations. The aim of this study was to create updated Swedish national reference ranges for intrauterine size and growth of the fetal head, abdomen and femur from gestational week 12 to 42. This prospective longitudinal multicentre study included 583 healthy pregnant women with low risk of aberrant fetal growth. Each woman was examined up to five times with ultrasound from gestational week 12 + 3 to 41 + 6. The assessed intrauterine fetal biometric measurements were biparietal diameter (outer–inner), head circumference, mean abdominal diameter, abdominal circumference and femur length. A two-level hierarchical regression model was employed to account for the individual measurements of the fetus and the number of repeated visits for measurements while accounting for the random effect of the identified parameterization of gestational age. The expected median and variance, expressed in both standard deviations and percentiles, for each individual biometric measurement was calculated. The presented national reference ranges can be used for assessment of intrauterine size and growth of the fetal head, abdomen and femur in the second and third trimester of pregnancy.Linda LindströmMårten AgeheimOve AxelssonLaith Hussain-AlkhateebAlkistis SkalkidouEva BergmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Linda Lindström Mårten Ageheim Ove Axelsson Laith Hussain-Alkhateeb Alkistis Skalkidou Eva Bergman Swedish intrauterine growth reference ranges of biometric measurements of fetal head, abdomen and femur
description	Abstract Ultrasonic assessment of fetal growth is an important part of obstetric care to prevent adverse pregnancy outcome. However, lack of reliable reference ranges is a major barrier for accurate interpretation of the examinations. The aim of this study was to create updated Swedish national reference ranges for intrauterine size and growth of the fetal head, abdomen and femur from gestational week 12 to 42. This prospective longitudinal multicentre study included 583 healthy pregnant women with low risk of aberrant fetal growth. Each woman was examined up to five times with ultrasound from gestational week 12 + 3 to 41 + 6. The assessed intrauterine fetal biometric measurements were biparietal diameter (outer–inner), head circumference, mean abdominal diameter, abdominal circumference and femur length. A two-level hierarchical regression model was employed to account for the individual measurements of the fetus and the number of repeated visits for measurements while accounting for the random effect of the identified parameterization of gestational age. The expected median and variance, expressed in both standard deviations and percentiles, for each individual biometric measurement was calculated. The presented national reference ranges can be used for assessment of intrauterine size and growth of the fetal head, abdomen and femur in the second and third trimester of pregnancy.
format	article
author	Linda Lindström Mårten Ageheim Ove Axelsson Laith Hussain-Alkhateeb Alkistis Skalkidou Eva Bergman
author_facet	Linda Lindström Mårten Ageheim Ove Axelsson Laith Hussain-Alkhateeb Alkistis Skalkidou Eva Bergman
author_sort	Linda Lindström
title	Swedish intrauterine growth reference ranges of biometric measurements of fetal head, abdomen and femur
title_short	Swedish intrauterine growth reference ranges of biometric measurements of fetal head, abdomen and femur
title_full	Swedish intrauterine growth reference ranges of biometric measurements of fetal head, abdomen and femur
title_fullStr	Swedish intrauterine growth reference ranges of biometric measurements of fetal head, abdomen and femur
title_full_unstemmed	Swedish intrauterine growth reference ranges of biometric measurements of fetal head, abdomen and femur
title_sort	swedish intrauterine growth reference ranges of biometric measurements of fetal head, abdomen and femur
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c649cd1db0c64b17931a43f9932f6081
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Swedish intrauterine growth reference ranges of biometric measurements of fetal head, abdomen and femur

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