Human cardiac myosin light chain 4 (MYL4) mosaic expression patterns vary by sex

Abstract Sex disparities modulate cardiac function, although the proteins and mechanisms remain to be elucidated. We recently demonstrated a mosaic pattern of protein expression in the heart for over 100 proteins. Here we investigate one of these proteins, myosin light chain 4 (MYL4), which is impor...

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Autores principales:	Tony Y. Wang, Dan E. Arking, Joseph J. Maleszewski, Karen Fox-Talbot, Tim O. Nieuwenhuis, Lakshmi Santhanam, Renu Virmani, Avi Z. Rosenberg, Marc K. Halushka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c652c0835d9b4550b6cb7d45311e73b4
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spelling	oai:doaj.org-article:c652c0835d9b4550b6cb7d45311e73b42021-12-02T15:08:08ZHuman cardiac myosin light chain 4 (MYL4) mosaic expression patterns vary by sex10.1038/s41598-019-49191-02045-2322https://doaj.org/article/c652c0835d9b4550b6cb7d45311e73b42019-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-49191-0https://doaj.org/toc/2045-2322Abstract Sex disparities modulate cardiac function, although the proteins and mechanisms remain to be elucidated. We recently demonstrated a mosaic pattern of protein expression in the heart for over 100 proteins. Here we investigate one of these proteins, myosin light chain 4 (MYL4), which is important for contractile functions by increasing force production. We assayed the expression pattern of MYL4 across 756 ventricular myocardial samples from 668 individuals utilizing a semi-automated Cell Profiler method on five tissue microarrays (TMAs) of cardiac tissues across a diverse set of diseases. The percentage of MYL4 positive cells was significantly higher in male subjects independently across all five TMAs, regardless of disease state (p = 8.66e-15). Higher MYL4 expression was also modestly associated with hypertrophic cardiomyopathy (p = 6.3e-04). MYL4 expression did not associate with sudden cardiac death or other cardiomyopathies. This study demonstrates a new mosaic pattern of protein expression that underlies sex disparities in the human heart.Tony Y. WangDan E. ArkingJoseph J. MaleszewskiKaren Fox-TalbotTim O. NieuwenhuisLakshmi SanthanamRenu VirmaniAvi Z. RosenbergMarc K. HalushkaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tony Y. Wang Dan E. Arking Joseph J. Maleszewski Karen Fox-Talbot Tim O. Nieuwenhuis Lakshmi Santhanam Renu Virmani Avi Z. Rosenberg Marc K. Halushka Human cardiac myosin light chain 4 (MYL4) mosaic expression patterns vary by sex
description	Abstract Sex disparities modulate cardiac function, although the proteins and mechanisms remain to be elucidated. We recently demonstrated a mosaic pattern of protein expression in the heart for over 100 proteins. Here we investigate one of these proteins, myosin light chain 4 (MYL4), which is important for contractile functions by increasing force production. We assayed the expression pattern of MYL4 across 756 ventricular myocardial samples from 668 individuals utilizing a semi-automated Cell Profiler method on five tissue microarrays (TMAs) of cardiac tissues across a diverse set of diseases. The percentage of MYL4 positive cells was significantly higher in male subjects independently across all five TMAs, regardless of disease state (p = 8.66e-15). Higher MYL4 expression was also modestly associated with hypertrophic cardiomyopathy (p = 6.3e-04). MYL4 expression did not associate with sudden cardiac death or other cardiomyopathies. This study demonstrates a new mosaic pattern of protein expression that underlies sex disparities in the human heart.
format	article
author	Tony Y. Wang Dan E. Arking Joseph J. Maleszewski Karen Fox-Talbot Tim O. Nieuwenhuis Lakshmi Santhanam Renu Virmani Avi Z. Rosenberg Marc K. Halushka
author_facet	Tony Y. Wang Dan E. Arking Joseph J. Maleszewski Karen Fox-Talbot Tim O. Nieuwenhuis Lakshmi Santhanam Renu Virmani Avi Z. Rosenberg Marc K. Halushka
author_sort	Tony Y. Wang
title	Human cardiac myosin light chain 4 (MYL4) mosaic expression patterns vary by sex
title_short	Human cardiac myosin light chain 4 (MYL4) mosaic expression patterns vary by sex
title_full	Human cardiac myosin light chain 4 (MYL4) mosaic expression patterns vary by sex
title_fullStr	Human cardiac myosin light chain 4 (MYL4) mosaic expression patterns vary by sex
title_full_unstemmed	Human cardiac myosin light chain 4 (MYL4) mosaic expression patterns vary by sex
title_sort	human cardiac myosin light chain 4 (myl4) mosaic expression patterns vary by sex
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c652c0835d9b4550b6cb7d45311e73b4
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Human cardiac myosin light chain 4 (MYL4) mosaic expression patterns vary by sex

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