Ferroptosis-Associated Classifier and Indicator for Prognostic Prediction in Cutaneous Melanoma

Ferroptosis plays a critical role in different types of cancers, but the prognostic impact of ferroptosis in cutaneous melanoma remains lacking. Therefore, ferroptosis-related genes (FRGs) were firstly obtained from the FerrDb database and the differentially expressed FRGs were identified by the “li...

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Autores principales:	Hao Zeng, Cong You, Leran Zhao, Jiangyi Wang, Xiaoying Ye, Tao Yang, Chunlei Wan, Longying Deng
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/c654ff41d11b49dbbfb654c4f9e63597
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spelling	oai:doaj.org-article:c654ff41d11b49dbbfb654c4f9e635972021-11-08T02:35:26ZFerroptosis-Associated Classifier and Indicator for Prognostic Prediction in Cutaneous Melanoma1687-846910.1155/2021/3658196https://doaj.org/article/c654ff41d11b49dbbfb654c4f9e635972021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/3658196https://doaj.org/toc/1687-8469Ferroptosis plays a critical role in different types of cancers, but the prognostic impact of ferroptosis in cutaneous melanoma remains lacking. Therefore, ferroptosis-related genes (FRGs) were firstly obtained from the FerrDb database and the differentially expressed FRGs were identified by the “limma” algorithm. Next, the prognostic differentially expressed FRGs were screened out by univariate Cox regression, which were subsequently used to cluster melanomas into two subtypes (clusters A and B). Besides, the Boruta algorithm and principal component analysis (PCA) were performed to build a 15-FRGs indicator, which can robustly predict patients’ overall survival (OS) and be considered as an independent prognostic factor in melanoma. The melanoma patients were further divided into high- and low-FRGs score groups. The high score group have a good prognosis, with higher T cell immune infiltrating and lower mutation frequencies in NRAS, KRAS, and NF1. Finally, we discovered that many immune processes and several chemotherapy drugs were closely associated with FRGs score. Thus, our study provides a novel ferroptosis-associated classifier and indicator to predict the prognosis of melanoma. Besides, we identified several potential chemotherapy drugs to induce ferroptosis and could supply additional effective treatments.Hao ZengCong YouLeran ZhaoJiangyi WangXiaoying YeTao YangChunlei WanLongying DengHindawi LimitedarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Oncology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hao Zeng Cong You Leran Zhao Jiangyi Wang Xiaoying Ye Tao Yang Chunlei Wan Longying Deng Ferroptosis-Associated Classifier and Indicator for Prognostic Prediction in Cutaneous Melanoma
description	Ferroptosis plays a critical role in different types of cancers, but the prognostic impact of ferroptosis in cutaneous melanoma remains lacking. Therefore, ferroptosis-related genes (FRGs) were firstly obtained from the FerrDb database and the differentially expressed FRGs were identified by the “limma” algorithm. Next, the prognostic differentially expressed FRGs were screened out by univariate Cox regression, which were subsequently used to cluster melanomas into two subtypes (clusters A and B). Besides, the Boruta algorithm and principal component analysis (PCA) were performed to build a 15-FRGs indicator, which can robustly predict patients’ overall survival (OS) and be considered as an independent prognostic factor in melanoma. The melanoma patients were further divided into high- and low-FRGs score groups. The high score group have a good prognosis, with higher T cell immune infiltrating and lower mutation frequencies in NRAS, KRAS, and NF1. Finally, we discovered that many immune processes and several chemotherapy drugs were closely associated with FRGs score. Thus, our study provides a novel ferroptosis-associated classifier and indicator to predict the prognosis of melanoma. Besides, we identified several potential chemotherapy drugs to induce ferroptosis and could supply additional effective treatments.
format	article
author	Hao Zeng Cong You Leran Zhao Jiangyi Wang Xiaoying Ye Tao Yang Chunlei Wan Longying Deng
author_facet	Hao Zeng Cong You Leran Zhao Jiangyi Wang Xiaoying Ye Tao Yang Chunlei Wan Longying Deng
author_sort	Hao Zeng
title	Ferroptosis-Associated Classifier and Indicator for Prognostic Prediction in Cutaneous Melanoma
title_short	Ferroptosis-Associated Classifier and Indicator for Prognostic Prediction in Cutaneous Melanoma
title_full	Ferroptosis-Associated Classifier and Indicator for Prognostic Prediction in Cutaneous Melanoma
title_fullStr	Ferroptosis-Associated Classifier and Indicator for Prognostic Prediction in Cutaneous Melanoma
title_full_unstemmed	Ferroptosis-Associated Classifier and Indicator for Prognostic Prediction in Cutaneous Melanoma
title_sort	ferroptosis-associated classifier and indicator for prognostic prediction in cutaneous melanoma
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/c654ff41d11b49dbbfb654c4f9e63597
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Ferroptosis-Associated Classifier and Indicator for Prognostic Prediction in Cutaneous Melanoma

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