Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole

TRPV6 is a calcium-selective ion channel that is involved in numerous calcium-dependent physiological processes and it is of interest as a potential drug target. Here, the authors present the cryo-EM structures of human TRPV6 with the bound inhibitors ruthenium red and the antifungal drug econazole...

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Autores principales:	Arthur Neuberger, Kirill D. Nadezhdin, Alexander I. Sobolevsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c655b2e004b0428cb1826694f8cb395f
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spelling	oai:doaj.org-article:c655b2e004b0428cb1826694f8cb395f2021-11-08T11:05:45ZStructural mechanisms of TRPV6 inhibition by ruthenium red and econazole10.1038/s41467-021-26608-x2041-1723https://doaj.org/article/c655b2e004b0428cb1826694f8cb395f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26608-xhttps://doaj.org/toc/2041-1723TRPV6 is a calcium-selective ion channel that is involved in numerous calcium-dependent physiological processes and it is of interest as a potential drug target. Here, the authors present the cryo-EM structures of human TRPV6 with the bound inhibitors ruthenium red and the antifungal drug econazole and discuss their inhibition mechanisms.Arthur NeubergerKirill D. NadezhdinAlexander I. SobolevskyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arthur Neuberger Kirill D. Nadezhdin Alexander I. Sobolevsky Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
description	TRPV6 is a calcium-selective ion channel that is involved in numerous calcium-dependent physiological processes and it is of interest as a potential drug target. Here, the authors present the cryo-EM structures of human TRPV6 with the bound inhibitors ruthenium red and the antifungal drug econazole and discuss their inhibition mechanisms.
format	article
author	Arthur Neuberger Kirill D. Nadezhdin Alexander I. Sobolevsky
author_facet	Arthur Neuberger Kirill D. Nadezhdin Alexander I. Sobolevsky
author_sort	Arthur Neuberger
title	Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
title_short	Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
title_full	Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
title_fullStr	Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
title_full_unstemmed	Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
title_sort	structural mechanisms of trpv6 inhibition by ruthenium red and econazole
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c655b2e004b0428cb1826694f8cb395f
work_keys_str_mv	AT arthurneuberger structuralmechanismsoftrpv6inhibitionbyrutheniumredandeconazole AT kirilldnadezhdin structuralmechanismsoftrpv6inhibitionbyrutheniumredandeconazole AT alexanderisobolevsky structuralmechanismsoftrpv6inhibitionbyrutheniumredandeconazole
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Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole

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