Genetic polymorphisms of inflammasome genes associated with pediatric acute lymphoblastic leukemia and clinical prognosis in the Brazilian Amazon

Abstract The immune system plays an important role in the control of cancer development. To investigate the possible association of inflammasome genes to childhood leukemia we performed a case-control study with 158 patients with acute lymphoblastic leukemia and 192 healthy individuals. The IL1B and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fabíola Silva Alves, Lilyane Amorim Xabregas, Marlon Wendell Athaydes Kerr, Gláucia Lima Souza, Daniele Sá Pereira, Fábio Magalhães-Gama, Mirian Rodrigues Ribeiro Santiago, Nadja Pinto Garcia, Andréa Monteiro Tarragô, Maurício Morishi Ogusku, Aya Sadahiro, Adriana Malheiro, Allyson Guimarães Costa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c6581352467147baaa074e5758e4f754
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c6581352467147baaa074e5758e4f754
record_format	dspace
spelling	oai:doaj.org-article:c6581352467147baaa074e5758e4f7542021-12-02T16:57:57ZGenetic polymorphisms of inflammasome genes associated with pediatric acute lymphoblastic leukemia and clinical prognosis in the Brazilian Amazon10.1038/s41598-021-89310-42045-2322https://doaj.org/article/c6581352467147baaa074e5758e4f7542021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89310-4https://doaj.org/toc/2045-2322Abstract The immune system plays an important role in the control of cancer development. To investigate the possible association of inflammasome genes to childhood leukemia we performed a case-control study with 158 patients with acute lymphoblastic leukemia and 192 healthy individuals. The IL1B and IL18 genetic polymorphisms were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and NLRP1, NLRP3 and P2RX7 were genotyped using Real Time quantitative PCR (qPCR). The IL1B C/T rs19644 genotype was associated with the risk of developing ALL (C/C vs. C/T + T/T OR: 2.48 [95% CI: 1.26–4.88, p = 0.006]; C/C vs C/T OR: 2.74 [95% CI: 1.37–5.51, p = 0.003]) and the NLRP1 A/T rs12150220 (OR: 0.37 [95% CI: 0.16–0.87, p = 0.023]) was associated with protection against infectious comorbidities. It was not found association between NLRP3 and P2RX7 polymorphisms and acute lymphoblastic leukemia in our study. Our results suggest that the inflammasome single-variant polymorphisms (SNVs) may play a role in the development and prognostic of childhood leukemia. However, this finds requires further study within a larger population in order to prove it.Fabíola Silva AlvesLilyane Amorim XabregasMarlon Wendell Athaydes KerrGláucia Lima SouzaDaniele Sá PereiraFábio Magalhães-GamaMirian Rodrigues Ribeiro SantiagoNadja Pinto GarciaAndréa Monteiro TarragôMaurício Morishi OguskuAya SadahiroAdriana MalheiroAllyson Guimarães CostaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fabíola Silva Alves Lilyane Amorim Xabregas Marlon Wendell Athaydes Kerr Gláucia Lima Souza Daniele Sá Pereira Fábio Magalhães-Gama Mirian Rodrigues Ribeiro Santiago Nadja Pinto Garcia Andréa Monteiro Tarragô Maurício Morishi Ogusku Aya Sadahiro Adriana Malheiro Allyson Guimarães Costa Genetic polymorphisms of inflammasome genes associated with pediatric acute lymphoblastic leukemia and clinical prognosis in the Brazilian Amazon
description	Abstract The immune system plays an important role in the control of cancer development. To investigate the possible association of inflammasome genes to childhood leukemia we performed a case-control study with 158 patients with acute lymphoblastic leukemia and 192 healthy individuals. The IL1B and IL18 genetic polymorphisms were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and NLRP1, NLRP3 and P2RX7 were genotyped using Real Time quantitative PCR (qPCR). The IL1B C/T rs19644 genotype was associated with the risk of developing ALL (C/C vs. C/T + T/T OR: 2.48 [95% CI: 1.26–4.88, p = 0.006]; C/C vs C/T OR: 2.74 [95% CI: 1.37–5.51, p = 0.003]) and the NLRP1 A/T rs12150220 (OR: 0.37 [95% CI: 0.16–0.87, p = 0.023]) was associated with protection against infectious comorbidities. It was not found association between NLRP3 and P2RX7 polymorphisms and acute lymphoblastic leukemia in our study. Our results suggest that the inflammasome single-variant polymorphisms (SNVs) may play a role in the development and prognostic of childhood leukemia. However, this finds requires further study within a larger population in order to prove it.
format	article
author	Fabíola Silva Alves Lilyane Amorim Xabregas Marlon Wendell Athaydes Kerr Gláucia Lima Souza Daniele Sá Pereira Fábio Magalhães-Gama Mirian Rodrigues Ribeiro Santiago Nadja Pinto Garcia Andréa Monteiro Tarragô Maurício Morishi Ogusku Aya Sadahiro Adriana Malheiro Allyson Guimarães Costa
author_facet	Fabíola Silva Alves Lilyane Amorim Xabregas Marlon Wendell Athaydes Kerr Gláucia Lima Souza Daniele Sá Pereira Fábio Magalhães-Gama Mirian Rodrigues Ribeiro Santiago Nadja Pinto Garcia Andréa Monteiro Tarragô Maurício Morishi Ogusku Aya Sadahiro Adriana Malheiro Allyson Guimarães Costa
author_sort	Fabíola Silva Alves
title	Genetic polymorphisms of inflammasome genes associated with pediatric acute lymphoblastic leukemia and clinical prognosis in the Brazilian Amazon
title_short	Genetic polymorphisms of inflammasome genes associated with pediatric acute lymphoblastic leukemia and clinical prognosis in the Brazilian Amazon
title_full	Genetic polymorphisms of inflammasome genes associated with pediatric acute lymphoblastic leukemia and clinical prognosis in the Brazilian Amazon
title_fullStr	Genetic polymorphisms of inflammasome genes associated with pediatric acute lymphoblastic leukemia and clinical prognosis in the Brazilian Amazon
title_full_unstemmed	Genetic polymorphisms of inflammasome genes associated with pediatric acute lymphoblastic leukemia and clinical prognosis in the Brazilian Amazon
title_sort	genetic polymorphisms of inflammasome genes associated with pediatric acute lymphoblastic leukemia and clinical prognosis in the brazilian amazon
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c6581352467147baaa074e5758e4f754
work_keys_str_mv	AT fabiolasilvaalves geneticpolymorphismsofinflammasomegenesassociatedwithpediatricacutelymphoblasticleukemiaandclinicalprognosisinthebrazilianamazon AT lilyaneamorimxabregas geneticpolymorphismsofinflammasomegenesassociatedwithpediatricacutelymphoblasticleukemiaandclinicalprognosisinthebrazilianamazon AT marlonwendellathaydeskerr geneticpolymorphismsofinflammasomegenesassociatedwithpediatricacutelymphoblasticleukemiaandclinicalprognosisinthebrazilianamazon AT glaucialimasouza geneticpolymorphismsofinflammasomegenesassociatedwithpediatricacutelymphoblasticleukemiaandclinicalprognosisinthebrazilianamazon AT danielesapereira geneticpolymorphismsofinflammasomegenesassociatedwithpediatricacutelymphoblasticleukemiaandclinicalprognosisinthebrazilianamazon AT fabiomagalhaesgama geneticpolymorphismsofinflammasomegenesassociatedwithpediatricacutelymphoblasticleukemiaandclinicalprognosisinthebrazilianamazon AT mirianrodriguesribeirosantiago geneticpolymorphismsofinflammasomegenesassociatedwithpediatricacutelymphoblasticleukemiaandclinicalprognosisinthebrazilianamazon AT nadjapintogarcia geneticpolymorphismsofinflammasomegenesassociatedwithpediatricacutelymphoblasticleukemiaandclinicalprognosisinthebrazilianamazon AT andreamonteirotarrago geneticpolymorphismsofinflammasomegenesassociatedwithpediatricacutelymphoblasticleukemiaandclinicalprognosisinthebrazilianamazon AT mauriciomorishiogusku geneticpolymorphismsofinflammasomegenesassociatedwithpediatricacutelymphoblasticleukemiaandclinicalprognosisinthebrazilianamazon AT ayasadahiro geneticpolymorphismsofinflammasomegenesassociatedwithpediatricacutelymphoblasticleukemiaandclinicalprognosisinthebrazilianamazon AT adrianamalheiro geneticpolymorphismsofinflammasomegenesassociatedwithpediatricacutelymphoblasticleukemiaandclinicalprognosisinthebrazilianamazon AT allysonguimaraescosta geneticpolymorphismsofinflammasomegenesassociatedwithpediatricacutelymphoblasticleukemiaandclinicalprognosisinthebrazilianamazon
_version_	1718382471281639424

Genetic polymorphisms of inflammasome genes associated with pediatric acute lymphoblastic leukemia and clinical prognosis in the Brazilian Amazon

Ejemplares similares