Treatment Associated Changes of Functional Connectivity of Midbrain/Brainstem Nuclei in Major Depressive Disorder

Abstract Previous functional magnetic resonance imaging (fMRI) studies demonstrated an abnormally coordinated network functioning in Major Depression Disorder (MDD) during rest. The main monoamine-producing nuclei within midbrain/brainstem are functionally integrated within these specific networks....

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Autores principales:	Gerd Wagner, Feliberto de la Cruz, Stefanie Köhler, Karl-Jürgen Bär
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c658d55805604de5925529eb62d67ef8
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spelling	oai:doaj.org-article:c658d55805604de5925529eb62d67ef82021-12-02T12:30:44ZTreatment Associated Changes of Functional Connectivity of Midbrain/Brainstem Nuclei in Major Depressive Disorder10.1038/s41598-017-09077-52045-2322https://doaj.org/article/c658d55805604de5925529eb62d67ef82017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09077-5https://doaj.org/toc/2045-2322Abstract Previous functional magnetic resonance imaging (fMRI) studies demonstrated an abnormally coordinated network functioning in Major Depression Disorder (MDD) during rest. The main monoamine-producing nuclei within midbrain/brainstem are functionally integrated within these specific networks. Therefore, we aimed to investigate the resting-state functional connectivity (RSFC) of these nuclei in 45 MDD patients and differences between patients receiving two different classes of antidepressant drugs. Patients showed reduced RSFC from the ventral tegmental area (VTA) to dorsal anterior cingulate cortex (dACC) and stronger RSFC to the left amygdala and dorsolateral prefrontal cortex (DLPFC). Patients treated with antidepressants influencing noradrenergic and serotonergic neurotransmission showed different RSFC from locus coeruleus to DLPFC compared to patients treated with antidepressants influencing serotonergic neurotransmission only. In the opposite contrast patients showed stronger RSFC from dorsal raphe to posterior brain regions. Enhanced VTA-RSFC to amygdala as a central region of the salience network may indicate an over‐attribution of the affective salience to internally-oriented processes. Significant correlation between decreased VTA-dACC functional connectivity and the BDI-II somatic symptoms indicates an association with diminished volition and behavioral activation in MDD. The observed differences in the FC of the midbrain/brainstem nuclei between two classes of antidepressants suggest differential neural effects of SSRIs and SNRIs.Gerd WagnerFeliberto de la CruzStefanie KöhlerKarl-Jürgen BärNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gerd Wagner Feliberto de la Cruz Stefanie Köhler Karl-Jürgen Bär Treatment Associated Changes of Functional Connectivity of Midbrain/Brainstem Nuclei in Major Depressive Disorder
description	Abstract Previous functional magnetic resonance imaging (fMRI) studies demonstrated an abnormally coordinated network functioning in Major Depression Disorder (MDD) during rest. The main monoamine-producing nuclei within midbrain/brainstem are functionally integrated within these specific networks. Therefore, we aimed to investigate the resting-state functional connectivity (RSFC) of these nuclei in 45 MDD patients and differences between patients receiving two different classes of antidepressant drugs. Patients showed reduced RSFC from the ventral tegmental area (VTA) to dorsal anterior cingulate cortex (dACC) and stronger RSFC to the left amygdala and dorsolateral prefrontal cortex (DLPFC). Patients treated with antidepressants influencing noradrenergic and serotonergic neurotransmission showed different RSFC from locus coeruleus to DLPFC compared to patients treated with antidepressants influencing serotonergic neurotransmission only. In the opposite contrast patients showed stronger RSFC from dorsal raphe to posterior brain regions. Enhanced VTA-RSFC to amygdala as a central region of the salience network may indicate an over‐attribution of the affective salience to internally-oriented processes. Significant correlation between decreased VTA-dACC functional connectivity and the BDI-II somatic symptoms indicates an association with diminished volition and behavioral activation in MDD. The observed differences in the FC of the midbrain/brainstem nuclei between two classes of antidepressants suggest differential neural effects of SSRIs and SNRIs.
format	article
author	Gerd Wagner Feliberto de la Cruz Stefanie Köhler Karl-Jürgen Bär
author_facet	Gerd Wagner Feliberto de la Cruz Stefanie Köhler Karl-Jürgen Bär
author_sort	Gerd Wagner
title	Treatment Associated Changes of Functional Connectivity of Midbrain/Brainstem Nuclei in Major Depressive Disorder
title_short	Treatment Associated Changes of Functional Connectivity of Midbrain/Brainstem Nuclei in Major Depressive Disorder
title_full	Treatment Associated Changes of Functional Connectivity of Midbrain/Brainstem Nuclei in Major Depressive Disorder
title_fullStr	Treatment Associated Changes of Functional Connectivity of Midbrain/Brainstem Nuclei in Major Depressive Disorder
title_full_unstemmed	Treatment Associated Changes of Functional Connectivity of Midbrain/Brainstem Nuclei in Major Depressive Disorder
title_sort	treatment associated changes of functional connectivity of midbrain/brainstem nuclei in major depressive disorder
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c658d55805604de5925529eb62d67ef8
work_keys_str_mv	AT gerdwagner treatmentassociatedchangesoffunctionalconnectivityofmidbrainbrainstemnucleiinmajordepressivedisorder AT felibertodelacruz treatmentassociatedchangesoffunctionalconnectivityofmidbrainbrainstemnucleiinmajordepressivedisorder AT stefaniekohler treatmentassociatedchangesoffunctionalconnectivityofmidbrainbrainstemnucleiinmajordepressivedisorder AT karljurgenbar treatmentassociatedchangesoffunctionalconnectivityofmidbrainbrainstemnucleiinmajordepressivedisorder
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Treatment Associated Changes of Functional Connectivity of Midbrain/Brainstem Nuclei in Major Depressive Disorder

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