Prognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis

Abstract Risk factors associated with mortality in invasive pneumococcal disease remain unclear. The present work is a meta-analysis of studies that enrolled only patients with invasive pneumococcal disease and reported on mortality. Potentially eligible reports were identified from PubMed, CHAHL, a...

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Autores principales:	Hao Chen, Hiromi Matsumoto, Nobuyuki Horita, Yu Hara, Nobuaki Kobayashi, Takeshi Kaneko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c65a5fc1c524437fb6897948056f189c
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spelling	oai:doaj.org-article:c65a5fc1c524437fb6897948056f189c2021-12-02T15:02:49ZPrognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis10.1038/s41598-021-91234-y2045-2322https://doaj.org/article/c65a5fc1c524437fb6897948056f189c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91234-yhttps://doaj.org/toc/2045-2322Abstract Risk factors associated with mortality in invasive pneumococcal disease remain unclear. The present work is a meta-analysis of studies that enrolled only patients with invasive pneumococcal disease and reported on mortality. Potentially eligible reports were identified from PubMed, CHAHL, and Web of Science, comprising 26 reports in total. Overall mortality for invasive pneumococcal disease was reported as 20.8% (95% confidence interval (CI) 17.5–24%). Factors associated with mortality were age (odds ratio (OR) 3.04, 95% CI 2.5–3.68), nursing home (OR 1.62, 95% CI 1.13–2.32), nosocomial infection (OR 2.10, 95% CI 1.52–2.89), septic shock (OR 13.35, 95% CI 4.54–39.31), underlying chronic diseases (OR 2.34, 95% CI 1.78–3.09), solid organ tumor (OR 5.34, 95% CI 2.07–13.74), immunosuppressed status (OR 1.67, 95% CI 1.31–2.14), and alcohol abuse (OR 3.14, 95% CI 2.13–4.64). Mortality rates with invasive pneumococcal disease remained high, and these findings may help clinicians provide appropriate initial treatment for this disease.Hao ChenHiromi MatsumotoNobuyuki HoritaYu HaraNobuaki KobayashiTakeshi KanekoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hao Chen Hiromi Matsumoto Nobuyuki Horita Yu Hara Nobuaki Kobayashi Takeshi Kaneko Prognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis
description	Abstract Risk factors associated with mortality in invasive pneumococcal disease remain unclear. The present work is a meta-analysis of studies that enrolled only patients with invasive pneumococcal disease and reported on mortality. Potentially eligible reports were identified from PubMed, CHAHL, and Web of Science, comprising 26 reports in total. Overall mortality for invasive pneumococcal disease was reported as 20.8% (95% confidence interval (CI) 17.5–24%). Factors associated with mortality were age (odds ratio (OR) 3.04, 95% CI 2.5–3.68), nursing home (OR 1.62, 95% CI 1.13–2.32), nosocomial infection (OR 2.10, 95% CI 1.52–2.89), septic shock (OR 13.35, 95% CI 4.54–39.31), underlying chronic diseases (OR 2.34, 95% CI 1.78–3.09), solid organ tumor (OR 5.34, 95% CI 2.07–13.74), immunosuppressed status (OR 1.67, 95% CI 1.31–2.14), and alcohol abuse (OR 3.14, 95% CI 2.13–4.64). Mortality rates with invasive pneumococcal disease remained high, and these findings may help clinicians provide appropriate initial treatment for this disease.
format	article
author	Hao Chen Hiromi Matsumoto Nobuyuki Horita Yu Hara Nobuaki Kobayashi Takeshi Kaneko
author_facet	Hao Chen Hiromi Matsumoto Nobuyuki Horita Yu Hara Nobuaki Kobayashi Takeshi Kaneko
author_sort	Hao Chen
title	Prognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis
title_short	Prognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis
title_full	Prognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis
title_fullStr	Prognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis
title_full_unstemmed	Prognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis
title_sort	prognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c65a5fc1c524437fb6897948056f189c
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Prognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis

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