Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness
The role of histone mutations in leukemogenesis remains largely unexplored. In this study of AML, the authors show that histone mutations are early events that drive a more aggressive phenotype.
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Nature Portfolio
2019
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oai:doaj.org-article:c65cab72003240578c7b04815c5c955e2021-12-02T16:51:01ZMutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness10.1038/s41467-019-10705-z2041-1723https://doaj.org/article/c65cab72003240578c7b04815c5c955e2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10705-zhttps://doaj.org/toc/2041-1723The role of histone mutations in leukemogenesis remains largely unexplored. In this study of AML, the authors show that histone mutations are early events that drive a more aggressive phenotype.Meaghan BoileauMargret ShirinianTenzin GaydenAshot S. HarutyunyanCarol C. L. ChenLeonie G. MikaelHeather M. DuncanAndrea L. NeumannPatricia Arreba-TutusausNicolas De JayMichele ZeiniehKatya RossokhataYelu ZhangHamid NikbakhtCarine MouawadRadwan MassoudFelice FreyRihab NasrJean El CheikhMarwan El SabbanClaudia L. KleinmanRami MahfouzMark D. MindenNada JabadoAli BazarbachiKolja EppertNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
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EN |
| topic |
Science Q |
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Science Q Meaghan Boileau Margret Shirinian Tenzin Gayden Ashot S. Harutyunyan Carol C. L. Chen Leonie G. Mikael Heather M. Duncan Andrea L. Neumann Patricia Arreba-Tutusaus Nicolas De Jay Michele Zeinieh Katya Rossokhata Yelu Zhang Hamid Nikbakht Carine Mouawad Radwan Massoud Felice Frey Rihab Nasr Jean El Cheikh Marwan El Sabban Claudia L. Kleinman Rami Mahfouz Mark D. Minden Nada Jabado Ali Bazarbachi Kolja Eppert Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness |
| description |
The role of histone mutations in leukemogenesis remains largely unexplored. In this study of AML, the authors show that histone mutations are early events that drive a more aggressive phenotype. |
| format |
article |
| author |
Meaghan Boileau Margret Shirinian Tenzin Gayden Ashot S. Harutyunyan Carol C. L. Chen Leonie G. Mikael Heather M. Duncan Andrea L. Neumann Patricia Arreba-Tutusaus Nicolas De Jay Michele Zeinieh Katya Rossokhata Yelu Zhang Hamid Nikbakht Carine Mouawad Radwan Massoud Felice Frey Rihab Nasr Jean El Cheikh Marwan El Sabban Claudia L. Kleinman Rami Mahfouz Mark D. Minden Nada Jabado Ali Bazarbachi Kolja Eppert |
| author_facet |
Meaghan Boileau Margret Shirinian Tenzin Gayden Ashot S. Harutyunyan Carol C. L. Chen Leonie G. Mikael Heather M. Duncan Andrea L. Neumann Patricia Arreba-Tutusaus Nicolas De Jay Michele Zeinieh Katya Rossokhata Yelu Zhang Hamid Nikbakht Carine Mouawad Radwan Massoud Felice Frey Rihab Nasr Jean El Cheikh Marwan El Sabban Claudia L. Kleinman Rami Mahfouz Mark D. Minden Nada Jabado Ali Bazarbachi Kolja Eppert |
| author_sort |
Meaghan Boileau |
| title |
Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness |
| title_short |
Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness |
| title_full |
Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness |
| title_fullStr |
Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness |
| title_full_unstemmed |
Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness |
| title_sort |
mutant h3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/c65cab72003240578c7b04815c5c955e |
| work_keys_str_mv |
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