MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

In leukemia, diverse fusion proteins involving the MLL gene can drive oncogenic activity. Here, the authors describe a dependency of MLL-leukemia cells on the methyltransferase SETD2 to maintain genomic integrity during leukemia initiation and maintenance.

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Autores principales:	Anna Skucha, Jessica Ebner, Johannes Schmöllerl, Mareike Roth, Thomas Eder, Adrián César-Razquin, Alexey Stukalov, Sarah Vittori, Matthias Muhar, Bin Lu, Martin Aichinger, Julian Jude, André C. Müller, Balázs Győrffy, Christopher R. Vakoc, Peter Valent, Keiryn L. Bennett, Johannes Zuber, Giulio Superti-Furga, Florian Grebien
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c65cecc9bf1145a685881a4d0ac0ba9d
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spelling	oai:doaj.org-article:c65cecc9bf1145a685881a4d0ac0ba9d2021-12-02T15:34:45ZMLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity10.1038/s41467-018-04329-y2041-1723https://doaj.org/article/c65cecc9bf1145a685881a4d0ac0ba9d2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04329-yhttps://doaj.org/toc/2041-1723In leukemia, diverse fusion proteins involving the MLL gene can drive oncogenic activity. Here, the authors describe a dependency of MLL-leukemia cells on the methyltransferase SETD2 to maintain genomic integrity during leukemia initiation and maintenance.Anna SkuchaJessica EbnerJohannes SchmöllerlMareike RothThomas EderAdrián César-RazquinAlexey StukalovSarah VittoriMatthias MuharBin LuMartin AichingerJulian JudeAndré C. MüllerBalázs GyőrffyChristopher R. VakocPeter ValentKeiryn L. BennettJohannes ZuberGiulio Superti-FurgaFlorian GrebienNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anna Skucha Jessica Ebner Johannes Schmöllerl Mareike Roth Thomas Eder Adrián César-Razquin Alexey Stukalov Sarah Vittori Matthias Muhar Bin Lu Martin Aichinger Julian Jude André C. Müller Balázs Győrffy Christopher R. Vakoc Peter Valent Keiryn L. Bennett Johannes Zuber Giulio Superti-Furga Florian Grebien MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity
description	In leukemia, diverse fusion proteins involving the MLL gene can drive oncogenic activity. Here, the authors describe a dependency of MLL-leukemia cells on the methyltransferase SETD2 to maintain genomic integrity during leukemia initiation and maintenance.
format	article
author	Anna Skucha Jessica Ebner Johannes Schmöllerl Mareike Roth Thomas Eder Adrián César-Razquin Alexey Stukalov Sarah Vittori Matthias Muhar Bin Lu Martin Aichinger Julian Jude André C. Müller Balázs Győrffy Christopher R. Vakoc Peter Valent Keiryn L. Bennett Johannes Zuber Giulio Superti-Furga Florian Grebien
author_facet	Anna Skucha Jessica Ebner Johannes Schmöllerl Mareike Roth Thomas Eder Adrián César-Razquin Alexey Stukalov Sarah Vittori Matthias Muhar Bin Lu Martin Aichinger Julian Jude André C. Müller Balázs Győrffy Christopher R. Vakoc Peter Valent Keiryn L. Bennett Johannes Zuber Giulio Superti-Furga Florian Grebien
author_sort	Anna Skucha
title	MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity
title_short	MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity
title_full	MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity
title_fullStr	MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity
title_full_unstemmed	MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity
title_sort	mll-fusion-driven leukemia requires setd2 to safeguard genomic integrity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c65cecc9bf1145a685881a4d0ac0ba9d
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MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

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