Prediction of Neonatal hyperbilirubinemia by The Cord Blood Alkaline ‎Phosphatase

Background: Owing to early discharge of neonates from the hospital, the readmission rate has been increased. Therefore, early detection of jaundice and prompt measures are important. Measurements of bilirubin and alkaline phosphatase levels in cord blood have been used for this function. The aim...

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Autores principales:	Esraa Farahat, Hany El-khaleegy, Hesham Abd Al-samee, Saad Mohamed
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	alkaline phosphatase enzyme bilirubin neonate hyperbilirubinemia Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c65ed072622246718f981e3aaaec9c9c
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spelling	oai:doaj.org-article:c65ed072622246718f981e3aaaec9c9c2021-12-02T15:54:52ZPrediction of Neonatal hyperbilirubinemia by The Cord Blood Alkaline ‎Phosphatase2636-41742682-378010.21608/ijma.2021.48585.1200https://doaj.org/article/c65ed072622246718f981e3aaaec9c9c2021-04-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_159221_24ccae49da5d22be608dd59721072f7d.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Owing to early discharge of neonates from the hospital, the readmission rate has been increased. Therefore, early detection of jaundice and prompt measures are important. Measurements of bilirubin and alkaline phosphatase levels in cord blood have been used for this function. The aim of the work: To assess the cord blood alkaline phosphatase value in predicting neonatal jaundice. Patients and Methods: This study carried out during the period from August 2019 to January 2020 in pediatric department [Al-Azher University Hospital in Damietta]. This study included a total of 101 term infants with gestational age between 37 and 42 weeks, weighing more than 2500g born to healthy mothers. We performed an assessment of the complete medical history [maternal history and neonatal history]. Cord blood samples were collected for measurement of alkaline phosphatase. Neonates were followed-up for the emergence of jaundice. Infants with clinical jaundice were recalled and serum bilirubin level was measured. Significant indirect neonatal hyperbilirubinemia was considered. Results: The study showed that patients with neonatal jaundice had statistically significant higher reticulocyte count, alkaline phosphate level and total bilirubin than patients without neonatal jaundice. However, the study shows the best cut-off points of regarding ALP to predict neonatal jaundice in neonates. A value of 200 or more IU/L was the best cut-off point to predict occurrence with a sensitivity of 98.3%, a specificity of 97.6%. Conclusion: Increased alkaline phosphatase level in cord blood act as an indicator to neonatal jaundice, and may be used as a marker for early diagnosis.Esraa FarahatHany El-khaleegyHesham Abd Al-sameeSaad MohamedAl-Azhar University, Faculty of Medicine (Damietta)articlealkaline phosphataseenzymebilirubinneonatehyperbilirubinemiaMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 2, Pp 1429-1436 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alkaline phosphatase enzyme bilirubin neonate hyperbilirubinemia Medicine (General) R5-920
spellingShingle	alkaline phosphatase enzyme bilirubin neonate hyperbilirubinemia Medicine (General) R5-920 Esraa Farahat Hany El-khaleegy Hesham Abd Al-samee Saad Mohamed Prediction of Neonatal hyperbilirubinemia by The Cord Blood Alkaline ‎Phosphatase
description	Background: Owing to early discharge of neonates from the hospital, the readmission rate has been increased. Therefore, early detection of jaundice and prompt measures are important. Measurements of bilirubin and alkaline phosphatase levels in cord blood have been used for this function. The aim of the work: To assess the cord blood alkaline phosphatase value in predicting neonatal jaundice. Patients and Methods: This study carried out during the period from August 2019 to January 2020 in pediatric department [Al-Azher University Hospital in Damietta]. This study included a total of 101 term infants with gestational age between 37 and 42 weeks, weighing more than 2500g born to healthy mothers. We performed an assessment of the complete medical history [maternal history and neonatal history]. Cord blood samples were collected for measurement of alkaline phosphatase. Neonates were followed-up for the emergence of jaundice. Infants with clinical jaundice were recalled and serum bilirubin level was measured. Significant indirect neonatal hyperbilirubinemia was considered. Results: The study showed that patients with neonatal jaundice had statistically significant higher reticulocyte count, alkaline phosphate level and total bilirubin than patients without neonatal jaundice. However, the study shows the best cut-off points of regarding ALP to predict neonatal jaundice in neonates. A value of 200 or more IU/L was the best cut-off point to predict occurrence with a sensitivity of 98.3%, a specificity of 97.6%. Conclusion: Increased alkaline phosphatase level in cord blood act as an indicator to neonatal jaundice, and may be used as a marker for early diagnosis.
format	article
author	Esraa Farahat Hany El-khaleegy Hesham Abd Al-samee Saad Mohamed
author_facet	Esraa Farahat Hany El-khaleegy Hesham Abd Al-samee Saad Mohamed
author_sort	Esraa Farahat
title	Prediction of Neonatal hyperbilirubinemia by The Cord Blood Alkaline ‎Phosphatase
title_short	Prediction of Neonatal hyperbilirubinemia by The Cord Blood Alkaline ‎Phosphatase
title_full	Prediction of Neonatal hyperbilirubinemia by The Cord Blood Alkaline ‎Phosphatase
title_fullStr	Prediction of Neonatal hyperbilirubinemia by The Cord Blood Alkaline ‎Phosphatase
title_full_unstemmed	Prediction of Neonatal hyperbilirubinemia by The Cord Blood Alkaline ‎Phosphatase
title_sort	prediction of neonatal hyperbilirubinemia by the cord blood alkaline ‎phosphatase
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/c65ed072622246718f981e3aaaec9c9c
work_keys_str_mv	AT esraafarahat predictionofneonatalhyperbilirubinemiabythecordbloodalkalinephosphatase AT hanyelkhaleegy predictionofneonatalhyperbilirubinemiabythecordbloodalkalinephosphatase AT heshamabdalsamee predictionofneonatalhyperbilirubinemiabythecordbloodalkalinephosphatase AT saadmohamed predictionofneonatalhyperbilirubinemiabythecordbloodalkalinephosphatase
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Prediction of Neonatal hyperbilirubinemia by The Cord Blood Alkaline ‎Phosphatase

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