Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine

Aging is the major risk factor for cardiovascular diseases due to chronic, low-grade inflammation stemmed from pro-inflammatory factors circulating in the body. Here, the authors identify a role of hepatocyte specific peroxisomal import in mediating non-autonomous regulation of cardiac aging, throug...

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Autores principales:	Kerui Huang, Ting Miao, Kai Chang, Jinoh Kim, Ping Kang, Qiuhan Jiang, Andrew J. Simmonds, Francesca Di Cara, Hua Bai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c6628dff572745b6bc2fc1183542436d
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spelling	oai:doaj.org-article:c6628dff572745b6bc2fc1183542436d2021-12-02T14:58:24ZImpaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine10.1038/s41467-020-16781-w2041-1723https://doaj.org/article/c6628dff572745b6bc2fc1183542436d2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16781-whttps://doaj.org/toc/2041-1723Aging is the major risk factor for cardiovascular diseases due to chronic, low-grade inflammation stemmed from pro-inflammatory factors circulating in the body. Here, the authors identify a role of hepatocyte specific peroxisomal import in mediating non-autonomous regulation of cardiac aging, through upregulation of IL6-like inflammatory cytokine.Kerui HuangTing MiaoKai ChangJinoh KimPing KangQiuhan JiangAndrew J. SimmondsFrancesca Di CaraHua BaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kerui Huang Ting Miao Kai Chang Jinoh Kim Ping Kang Qiuhan Jiang Andrew J. Simmonds Francesca Di Cara Hua Bai Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine
description	Aging is the major risk factor for cardiovascular diseases due to chronic, low-grade inflammation stemmed from pro-inflammatory factors circulating in the body. Here, the authors identify a role of hepatocyte specific peroxisomal import in mediating non-autonomous regulation of cardiac aging, through upregulation of IL6-like inflammatory cytokine.
format	article
author	Kerui Huang Ting Miao Kai Chang Jinoh Kim Ping Kang Qiuhan Jiang Andrew J. Simmonds Francesca Di Cara Hua Bai
author_facet	Kerui Huang Ting Miao Kai Chang Jinoh Kim Ping Kang Qiuhan Jiang Andrew J. Simmonds Francesca Di Cara Hua Bai
author_sort	Kerui Huang
title	Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine
title_short	Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine
title_full	Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine
title_fullStr	Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine
title_full_unstemmed	Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine
title_sort	impaired peroxisomal import in drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c6628dff572745b6bc2fc1183542436d
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Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine

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